Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging
Abstract Background Recent advances in rapid imaging techniques necessitate the reconsideration of the optimal imaging delay time for contrast-enhanced T1-weighted imaging. The aim of our study was to determine the optimal contrast-enhanced T1-weighted imaging delay time from the obtained time-signa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-022-00909-z |
| _version_ | 1811336519056621568 |
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| author | Jeemin Seo Changmok Lim Kye Young Lee Young-Cho Koh Won-Jin Moon |
| author_facet | Jeemin Seo Changmok Lim Kye Young Lee Young-Cho Koh Won-Jin Moon |
| author_sort | Jeemin Seo |
| collection | DOAJ |
| description | Abstract Background Recent advances in rapid imaging techniques necessitate the reconsideration of the optimal imaging delay time for contrast-enhanced T1-weighted imaging. The aim of our study was to determine the optimal contrast-enhanced T1-weighted imaging delay time from the obtained time-signal intensity curve (TIC) using gadobutrol in patients with brain metastases, primary brain tumors, and meningiomas. Methods This prospective study enrolled 78 patients with brain metastases (n = 39), primary brain tumors (n = 22), or meningiomas (n = 17) who underwent 7-min dynamic contrast-enhanced imaging with single-dose gadobutrol. Based on the time-to-peak (TTP) derived from the TIC, we selected four different time points for analysis. Lesion conspicuity, enhanced rate (ER) and contrast rate (CR) of 116 index lesions were evaluated. Statistical comparisons were made for the four different time points using the Friedman test. Results Maximum TTP (305.20 ± 63.47 s) was similar across all three groups (p = 0.342). Lesion conspicuity, CR and ER increased over time in all index lesions; however, no significant difference between the 5- and 7-min images was observed. The longest diameter in all groups differed significantly among time points (p < 0.001); the perpendicular diameter did not differ between the 5- and 7-min images. Conclusions Maximum contrast enhancement and lesion conspicuity was achieved 5–7 min after a single gadobutrol injection for brain metastases detection and for primary brain tumor/meningioma evaluation. Acquiring images 5 min after gadobutrol injection is the optimal timing for brain tumor detection during MRI work-up. |
| first_indexed | 2024-04-13T17:40:45Z |
| format | Article |
| id | doaj.art-a5c0880c23a84374b1e5693d06658d4f |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-04-13T17:40:45Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-a5c0880c23a84374b1e5693d06658d4f2022-12-22T02:37:11ZengBMCBMC Medical Imaging1471-23422022-10-0122111010.1186/s12880-022-00909-zTime optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imagingJeemin Seo0Changmok Lim1Kye Young Lee2Young-Cho Koh3Won-Jin Moon4Department of Radiology, Konkuk University Medical Center, Konkuk University School of MedicineDepartment of Radiology, Konkuk University Medical Center, Konkuk University School of MedicineDepartment of Internal Medicine, Konkuk University Medical Center, Konkuk University School of MedicineDepartment of Neurosurgery, Konkuk University Medical Center, Konkuk University School of MedicineDepartment of Radiology, Konkuk University Medical Center, Konkuk University School of MedicineAbstract Background Recent advances in rapid imaging techniques necessitate the reconsideration of the optimal imaging delay time for contrast-enhanced T1-weighted imaging. The aim of our study was to determine the optimal contrast-enhanced T1-weighted imaging delay time from the obtained time-signal intensity curve (TIC) using gadobutrol in patients with brain metastases, primary brain tumors, and meningiomas. Methods This prospective study enrolled 78 patients with brain metastases (n = 39), primary brain tumors (n = 22), or meningiomas (n = 17) who underwent 7-min dynamic contrast-enhanced imaging with single-dose gadobutrol. Based on the time-to-peak (TTP) derived from the TIC, we selected four different time points for analysis. Lesion conspicuity, enhanced rate (ER) and contrast rate (CR) of 116 index lesions were evaluated. Statistical comparisons were made for the four different time points using the Friedman test. Results Maximum TTP (305.20 ± 63.47 s) was similar across all three groups (p = 0.342). Lesion conspicuity, CR and ER increased over time in all index lesions; however, no significant difference between the 5- and 7-min images was observed. The longest diameter in all groups differed significantly among time points (p < 0.001); the perpendicular diameter did not differ between the 5- and 7-min images. Conclusions Maximum contrast enhancement and lesion conspicuity was achieved 5–7 min after a single gadobutrol injection for brain metastases detection and for primary brain tumor/meningioma evaluation. Acquiring images 5 min after gadobutrol injection is the optimal timing for brain tumor detection during MRI work-up.https://doi.org/10.1186/s12880-022-00909-zIntracerebral metastasesPrimary brain tumorGadobutrolMRIContrast agent |
| spellingShingle | Jeemin Seo Changmok Lim Kye Young Lee Young-Cho Koh Won-Jin Moon Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging BMC Medical Imaging Intracerebral metastases Primary brain tumor Gadobutrol MRI Contrast agent |
| title | Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging |
| title_full | Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging |
| title_fullStr | Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging |
| title_full_unstemmed | Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging |
| title_short | Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging |
| title_sort | time optimization of gadobutrol enhanced brain mri for metastases and primary tumors using a dynamic contrast enhanced imaging |
| topic | Intracerebral metastases Primary brain tumor Gadobutrol MRI Contrast agent |
| url | https://doi.org/10.1186/s12880-022-00909-z |
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