MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis
Salivary gland cancer (SGC) is an uncommon and heterogeneous disease that accounts for around 8.5% of all head and neck cancers. MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18–25 nucleotides) of noncoding RNA that represent key gene-transcription regul...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/21/5304 |
| _version_ | 1797468871989395456 |
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| author | Marco Bocchetti Piera Grisolia Federica Melisi Maria Grazia Ferraro Pietro De Luca Angelo Camaioni Michela Falco Marianna Abate Gabriella Misso Roberto Alfano Nunzio Accardo Flavia Oliva Alessia Maria Cossu Michele Caraglia Marianna Scrima Filippo Ricciardiello |
| author_facet | Marco Bocchetti Piera Grisolia Federica Melisi Maria Grazia Ferraro Pietro De Luca Angelo Camaioni Michela Falco Marianna Abate Gabriella Misso Roberto Alfano Nunzio Accardo Flavia Oliva Alessia Maria Cossu Michele Caraglia Marianna Scrima Filippo Ricciardiello |
| author_sort | Marco Bocchetti |
| collection | DOAJ |
| description | Salivary gland cancer (SGC) is an uncommon and heterogeneous disease that accounts for around 8.5% of all head and neck cancers. MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18–25 nucleotides) of noncoding RNA that represent key gene-transcription regulators in physiological and pathological human conditions. However, their role in SGC development and progression is not completely clear. This review aims to compile and summarize the recent findings on the topic, focusing on the prognostic and diagnostic value of the major modulated and validated microRNAs in SGC. Their differential expression could possibly aid the clinician in delivering an early diagnosis, therapeutic strategy and precision medicine. |
| first_indexed | 2024-03-09T19:12:27Z |
| format | Article |
| id | doaj.art-a5c20d1779fa4de7bbb9671f283c53d1 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T19:12:27Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a5c20d1779fa4de7bbb9671f283c53d12023-11-24T04:02:19ZengMDPI AGCancers2072-66942022-10-011421530410.3390/cancers14215304MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and PrognosisMarco Bocchetti0Piera Grisolia1Federica Melisi2Maria Grazia Ferraro3Pietro De Luca4Angelo Camaioni5Michela Falco6Marianna Abate7Gabriella Misso8Roberto Alfano9Nunzio Accardo10Flavia Oliva11Alessia Maria Cossu12Michele Caraglia13Marianna Scrima14Filippo Ricciardiello15Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, ItalyDepartment of Pharmacy, School of Medicine and Surgery, University of Naples “Federico II”, Via D. Montesano 49, 80131 Naples, ItalyDepartment of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, ItalyOtolaryngology Department, San Giovanni-Addolorata Hospital, Via dell’Amba Aradam, 8, 00184 Rome, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences “DAMSS”, University of Campania “Luigi Vanvitelli”, Via S.M. di Costantinopoli 104, 80138 Naples, ItalyEar Nose Throt Departement AORN Cardarelli, 80100 Napoli, ItalyEar Nose Throt Departement AORN Cardarelli, 80100 Napoli, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, ItalyLaboratory of Precision and Molecular Oncology, Biogem Scarl, Institute of Genetic Research, Contrada Camporeale, 83031 Ariano Irpino, ItalyEar Nose Throt Departement AORN Cardarelli, 80100 Napoli, ItalySalivary gland cancer (SGC) is an uncommon and heterogeneous disease that accounts for around 8.5% of all head and neck cancers. MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18–25 nucleotides) of noncoding RNA that represent key gene-transcription regulators in physiological and pathological human conditions. However, their role in SGC development and progression is not completely clear. This review aims to compile and summarize the recent findings on the topic, focusing on the prognostic and diagnostic value of the major modulated and validated microRNAs in SGC. Their differential expression could possibly aid the clinician in delivering an early diagnosis, therapeutic strategy and precision medicine.https://www.mdpi.com/2072-6694/14/21/5304salivary gland cancermicroRNAsbiomarkersdiagnosisprognosis |
| spellingShingle | Marco Bocchetti Piera Grisolia Federica Melisi Maria Grazia Ferraro Pietro De Luca Angelo Camaioni Michela Falco Marianna Abate Gabriella Misso Roberto Alfano Nunzio Accardo Flavia Oliva Alessia Maria Cossu Michele Caraglia Marianna Scrima Filippo Ricciardiello MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis Cancers salivary gland cancer microRNAs biomarkers diagnosis prognosis |
| title | MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis |
| title_full | MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis |
| title_fullStr | MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis |
| title_full_unstemmed | MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis |
| title_short | MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis |
| title_sort | micrornas crucial role in salivary gland cancers onset and prognosis |
| topic | salivary gland cancer microRNAs biomarkers diagnosis prognosis |
| url | https://www.mdpi.com/2072-6694/14/21/5304 |
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