HIV-1 Envelope Glycoprotein Cell Surface Localization Is Associated with Antibody-Induced Internalization

HIV-1 Envelope Glycoprotein Cell Surface Localization Is Associated with Antibody-Induced Internalization

To minimize immune responses against infected cells, HIV-1 has evolved different mechanisms to limit the surface expression of its envelope glycoproteins (Env). Recent observations suggest that the binding of certain broadly neutralizing antibodies (bNAbs) targeting the ‘closed’ conformation of Env...

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Bibliographic Details
Main Authors: Sai Priya Anand, Jérémie Prévost, Jade Descôteaux-Dinelle, Jonathan Richard, Dung N. Nguyen, Halima Medjahed, Hung-Ching Chen, Amos B. Smith, Marzena Pazgier, Andrés Finzi
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Viruses
Subjects:
HIV-1
non-neutralizing antibodies
broadly neutralizing antibodies
Env
internalization
endocytosis
Online Access:https://www.mdpi.com/1999-4915/13/10/1953

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