Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation
Despite conventional treatment options including chemoradiation, patients with the most aggressive primary brain tumor, glioblastoma multiforme (GBM), experience an average survival time of less than 15 months. Regarding the malignant nature of GBM, extensive research and discovery of novel treatmen...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222011295 |
| _version_ | 1811237702593413120 |
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| author | Mehdi Sanati Maryam Moradi Binabaj Seyed Sajad Ahmadi Samaneh Aminyavari Hossein Javid Hamid Mollazadeh Bahram Bibak Elmira Mohtashami Tannaz Jamialahmadi Amir R. Afshari Amirhossein Sahebkar |
| author_facet | Mehdi Sanati Maryam Moradi Binabaj Seyed Sajad Ahmadi Samaneh Aminyavari Hossein Javid Hamid Mollazadeh Bahram Bibak Elmira Mohtashami Tannaz Jamialahmadi Amir R. Afshari Amirhossein Sahebkar |
| author_sort | Mehdi Sanati |
| collection | DOAJ |
| description | Despite conventional treatment options including chemoradiation, patients with the most aggressive primary brain tumor, glioblastoma multiforme (GBM), experience an average survival time of less than 15 months. Regarding the malignant nature of GBM, extensive research and discovery of novel treatments are urgently required to improve the patients’ prognosis. Autophagy, a crucial physiological pathway for the degradation and recycling of cell components, is one of the exciting targets of GBM studies. Interventions aimed at autophagy activation or inhibition have been explored as potential GBM therapeutics. This review, which delves into therapeutic techniques to block or activate autophagy in preclinical and clinical research, aims to expand our understanding of available therapies battling GBM. |
| first_indexed | 2024-04-12T12:27:57Z |
| format | Article |
| id | doaj.art-a5c429610f3e41c9ac087c895f06cf49 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-12T12:27:57Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-a5c429610f3e41c9ac087c895f06cf492022-12-22T03:33:06ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-11-01155113740Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulationMehdi Sanati0Maryam Moradi Binabaj1Seyed Sajad Ahmadi2Samaneh Aminyavari3Hossein Javid4Hamid Mollazadeh5Bahram Bibak6Elmira Mohtashami7Tannaz Jamialahmadi8Amir R. Afshari9Amirhossein Sahebkar10Department of Pharmacology and Toxicology, Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran; Experimental and Animal Study Center, Birjand University of Medical Sciences, Birjand, IranNon-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, IranDepartment of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, IranDepartment of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, IranDepartment of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, IranNatural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, IranNatural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran; Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran; Corresponding author at: Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author at: Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Despite conventional treatment options including chemoradiation, patients with the most aggressive primary brain tumor, glioblastoma multiforme (GBM), experience an average survival time of less than 15 months. Regarding the malignant nature of GBM, extensive research and discovery of novel treatments are urgently required to improve the patients’ prognosis. Autophagy, a crucial physiological pathway for the degradation and recycling of cell components, is one of the exciting targets of GBM studies. Interventions aimed at autophagy activation or inhibition have been explored as potential GBM therapeutics. This review, which delves into therapeutic techniques to block or activate autophagy in preclinical and clinical research, aims to expand our understanding of available therapies battling GBM.http://www.sciencedirect.com/science/article/pii/S0753332222011295GlioblastomaAutophagyTherapyTumorigenesis |
| spellingShingle | Mehdi Sanati Maryam Moradi Binabaj Seyed Sajad Ahmadi Samaneh Aminyavari Hossein Javid Hamid Mollazadeh Bahram Bibak Elmira Mohtashami Tannaz Jamialahmadi Amir R. Afshari Amirhossein Sahebkar Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation Biomedicine & Pharmacotherapy Glioblastoma Autophagy Therapy Tumorigenesis |
| title | Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation |
| title_full | Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation |
| title_fullStr | Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation |
| title_full_unstemmed | Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation |
| title_short | Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation |
| title_sort | recent advances in glioblastoma multiforme therapy a focus on autophagy regulation |
| topic | Glioblastoma Autophagy Therapy Tumorigenesis |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222011295 |
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