Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform

Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform

Lujo virus (LUJV), a highly pathogenic arenavirus, was first identified in 2008 in Zambia. To aid the identification of effective therapeutics for LUJV, we developed a recombinant reporter virus system, confirming reporter LUJV comparability with wild-type virus and its utility in high-throughput an...

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Bibliographic Details
Main Authors: Stephen R. Welch, Jessica R. Spengler, Sarah C. Genzer, Payel Chatterjee, Mike Flint, Éric Bergeron, Joel M. Montgomery, Stuart T. Nichol, César G. Albariño, Christina F. Spiropoulou
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
Lujo virus
viral hemorrhagic fever
arenavirus
reporter virus
reverse genetics
antiviral screen
Online Access:https://www.mdpi.com/1999-4915/13/7/1255

Internet

https://www.mdpi.com/1999-4915/13/7/1255

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