Lower pattern recognition memory scores in anorexia nervosa
Plain English summary The hippocampus is an area of the brain that is vital for memory and learning, and it is not understood the extent to which its function is impaired in anorexia nervosa (AN). This paper used the Mnemonic Similarity Task to assess pattern separation, a hippocampus-dependent form...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-04-01
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| Series: | Journal of Eating Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40337-021-00406-8 |
| _version_ | 1797934769409884160 |
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| author | Johanna Keeler Ellen Lambert Miriam Olivola Judith Owen Jingjing Xia Sandrine Thuret Hubertus Himmerich Valentina Cardi Janet Treasure |
| author_facet | Johanna Keeler Ellen Lambert Miriam Olivola Judith Owen Jingjing Xia Sandrine Thuret Hubertus Himmerich Valentina Cardi Janet Treasure |
| author_sort | Johanna Keeler |
| collection | DOAJ |
| description | Plain English summary The hippocampus is an area of the brain that is vital for memory and learning, and it is not understood the extent to which its function is impaired in anorexia nervosa (AN). This paper used the Mnemonic Similarity Task to assess pattern separation, a hippocampus-dependent form of memory, in AN. This task involves showing participants a sequence of objects, who then categorise them as “indoor” or “outdoor” objects. Participants are later shown a sequence of objects, although some of the images are replaced by a similar but slightly different image. The task involves recognising whether an image has previously been seen (pattern recognition) and also whether it is similar to, but distinct, from a previous image (i.e. pattern separation). In this study, individuals with AN showed reduced performance in pattern recognition, when statistically controlling for their age, how the task was delivered and their use of antidepressant medication. However, their performance in pattern separation was intact. This may indicate an imbalance in this hippocampus-dependent form of memory in AN. |
| first_indexed | 2024-04-10T18:04:03Z |
| format | Article |
| id | doaj.art-a5c651b19cc64c5c8f79fddeaa4f957b |
| institution | Directory Open Access Journal |
| issn | 2050-2974 |
| language | English |
| last_indexed | 2024-04-10T18:04:03Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Eating Disorders |
| spelling | doaj.art-a5c651b19cc64c5c8f79fddeaa4f957b2023-02-02T13:44:37ZengBMCJournal of Eating Disorders2050-29742021-04-019111110.1186/s40337-021-00406-8Lower pattern recognition memory scores in anorexia nervosaJohanna Keeler0Ellen Lambert1Miriam Olivola2Judith Owen3Jingjing Xia4Sandrine Thuret5Hubertus Himmerich6Valentina Cardi7Janet Treasure8Section of Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSection of Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSection of Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSection of Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSection of Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSection of Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSection of Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSection of Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonPlain English summary The hippocampus is an area of the brain that is vital for memory and learning, and it is not understood the extent to which its function is impaired in anorexia nervosa (AN). This paper used the Mnemonic Similarity Task to assess pattern separation, a hippocampus-dependent form of memory, in AN. This task involves showing participants a sequence of objects, who then categorise them as “indoor” or “outdoor” objects. Participants are later shown a sequence of objects, although some of the images are replaced by a similar but slightly different image. The task involves recognising whether an image has previously been seen (pattern recognition) and also whether it is similar to, but distinct, from a previous image (i.e. pattern separation). In this study, individuals with AN showed reduced performance in pattern recognition, when statistically controlling for their age, how the task was delivered and their use of antidepressant medication. However, their performance in pattern separation was intact. This may indicate an imbalance in this hippocampus-dependent form of memory in AN.https://doi.org/10.1186/s40337-021-00406-8Anorexia nervosaPattern separationRecognition memoryMnemonic similarity taskHippocampus |
| spellingShingle | Johanna Keeler Ellen Lambert Miriam Olivola Judith Owen Jingjing Xia Sandrine Thuret Hubertus Himmerich Valentina Cardi Janet Treasure Lower pattern recognition memory scores in anorexia nervosa Journal of Eating Disorders Anorexia nervosa Pattern separation Recognition memory Mnemonic similarity task Hippocampus |
| title | Lower pattern recognition memory scores in anorexia nervosa |
| title_full | Lower pattern recognition memory scores in anorexia nervosa |
| title_fullStr | Lower pattern recognition memory scores in anorexia nervosa |
| title_full_unstemmed | Lower pattern recognition memory scores in anorexia nervosa |
| title_short | Lower pattern recognition memory scores in anorexia nervosa |
| title_sort | lower pattern recognition memory scores in anorexia nervosa |
| topic | Anorexia nervosa Pattern separation Recognition memory Mnemonic similarity task Hippocampus |
| url | https://doi.org/10.1186/s40337-021-00406-8 |
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