Patellar cartilage increase following ACL reconstruction with and without meniscal pathology: a two-year prospective MRI morphological study
Abstract Background Anterior cruciate ligament reconstruction (ACLR) together with concomitant meniscal injury are risk factors for the development of tibiofemoral (TF) osteoarthritis (OA), but the potential effect on the patellofemoral (PF) joint is unclear. The aim of this study was to: (i) invest...
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| Format: | Article |
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BMC
2021-10-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-021-04794-5 |
| _version_ | 1819116805143134208 |
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| author | Xinyang Wang Kim L. Bennell Yuanyuan Wang Karine Fortin David J. Saxby Bryce A. Killen Tim V. Wrigley Flavia M. Cicuttini Ans Van Ginckel David G. Lloyd Julian A. Feller Christopher J. Vertullo Tim Whitehead Price Gallie Adam L. Bryant |
| author_facet | Xinyang Wang Kim L. Bennell Yuanyuan Wang Karine Fortin David J. Saxby Bryce A. Killen Tim V. Wrigley Flavia M. Cicuttini Ans Van Ginckel David G. Lloyd Julian A. Feller Christopher J. Vertullo Tim Whitehead Price Gallie Adam L. Bryant |
| author_sort | Xinyang Wang |
| collection | DOAJ |
| description | Abstract Background Anterior cruciate ligament reconstruction (ACLR) together with concomitant meniscal injury are risk factors for the development of tibiofemoral (TF) osteoarthritis (OA), but the potential effect on the patellofemoral (PF) joint is unclear. The aim of this study was to: (i) investigate change in patellar cartilage morphology in individuals 2.5 to 4.5 years after ACLR with or without concomitant meniscal pathology and in healthy controls, and (ii) examine the association between baseline patellar cartilage defects and patellar cartilage volume change. Methods Thirty two isolated ACLR participants, 25 ACLR participants with combined meniscal pathology and nine healthy controls underwent knee magnetic resonance imaging (MRI) with 2-year intervals (baseline = 2.5 years post-ACLR). Patellar cartilage volume and cartilage defects were assessed from MRI using validated methods. Results Both ACLR groups showed patellar cartilage volume increased over 2 years (p < 0.05), and isolated ACLR group had greater annual percentage cartilage volume increase compared with controls (mean difference 3.6, 95% confidence interval (CI) 1.0, 6.3%, p = 0.008) and combined ACLR group (mean difference 2.2, 95% CI 0.2, 4.2%, p = 0.028). Patellar cartilage defects regressed in the isolated ACLR group over 2 years (p = 0.02; Z = − 2.33; r = 0.3). Baseline patellar cartilage defect score was positively associated with annual percentage cartilage volume increase (Regression coefficient B = 0.014; 95% CI 0.001, 0.027; p = 0.03) in the pooled ACLR participants. Conclusions Hypertrophic response was evident in the patellar cartilage of ACLR participants with and without meniscal pathology. Surprisingly, the increase in patellar cartilage volume was more pronounced in those with isolated ACLR. Although cartilage defects stabilised in the majority of ACLR participants, the severity of patellar cartilage defects at baseline influenced the magnitude of the cartilage hypertrophic response over the subsequent ~ 2 years. |
| first_indexed | 2024-12-22T05:22:55Z |
| format | Article |
| id | doaj.art-a5cae3116ada4c6984f5188428d2ba65 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-22T05:22:55Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-a5cae3116ada4c6984f5188428d2ba652022-12-21T18:37:40ZengBMCBMC Musculoskeletal Disorders1471-24742021-10-012211910.1186/s12891-021-04794-5Patellar cartilage increase following ACL reconstruction with and without meniscal pathology: a two-year prospective MRI morphological studyXinyang Wang0Kim L. Bennell1Yuanyuan Wang2Karine Fortin3David J. Saxby4Bryce A. Killen5Tim V. Wrigley6Flavia M. Cicuttini7Ans Van Ginckel8David G. Lloyd9Julian A. Feller10Christopher J. Vertullo11Tim Whitehead12Price Gallie13Adam L. Bryant14Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, The University of MelbourneCentre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, The University of MelbourneSchool of Public Health & Preventive Medicine, Monash UniversityCentre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, The University of MelbourneSchool of Allied Health Sciences, Griffith UniversityHuman Movement Biomechanics Research Group, KU LeuvenCentre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, The University of MelbourneSchool of Public Health & Preventive Medicine, Monash UniversityDepartment of Rehabilitation Sciences, Ghent UniversitySchool of Allied Health Sciences, Griffith UniversityOrthoSport VictoriaGriffith University Centre for Biomedical and Rehabilitation Engineering (GCORE), Menzies Health Institute QueenslandOrthoSport VictoriaCoast OrthopaedicsCentre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, The University of MelbourneAbstract Background Anterior cruciate ligament reconstruction (ACLR) together with concomitant meniscal injury are risk factors for the development of tibiofemoral (TF) osteoarthritis (OA), but the potential effect on the patellofemoral (PF) joint is unclear. The aim of this study was to: (i) investigate change in patellar cartilage morphology in individuals 2.5 to 4.5 years after ACLR with or without concomitant meniscal pathology and in healthy controls, and (ii) examine the association between baseline patellar cartilage defects and patellar cartilage volume change. Methods Thirty two isolated ACLR participants, 25 ACLR participants with combined meniscal pathology and nine healthy controls underwent knee magnetic resonance imaging (MRI) with 2-year intervals (baseline = 2.5 years post-ACLR). Patellar cartilage volume and cartilage defects were assessed from MRI using validated methods. Results Both ACLR groups showed patellar cartilage volume increased over 2 years (p < 0.05), and isolated ACLR group had greater annual percentage cartilage volume increase compared with controls (mean difference 3.6, 95% confidence interval (CI) 1.0, 6.3%, p = 0.008) and combined ACLR group (mean difference 2.2, 95% CI 0.2, 4.2%, p = 0.028). Patellar cartilage defects regressed in the isolated ACLR group over 2 years (p = 0.02; Z = − 2.33; r = 0.3). Baseline patellar cartilage defect score was positively associated with annual percentage cartilage volume increase (Regression coefficient B = 0.014; 95% CI 0.001, 0.027; p = 0.03) in the pooled ACLR participants. Conclusions Hypertrophic response was evident in the patellar cartilage of ACLR participants with and without meniscal pathology. Surprisingly, the increase in patellar cartilage volume was more pronounced in those with isolated ACLR. Although cartilage defects stabilised in the majority of ACLR participants, the severity of patellar cartilage defects at baseline influenced the magnitude of the cartilage hypertrophic response over the subsequent ~ 2 years.https://doi.org/10.1186/s12891-021-04794-5Anterior cruciate ligament reconstructionPost-traumatic osteoarthritisCartilage volumeCartilage defectsPatellofemoral joint |
| spellingShingle | Xinyang Wang Kim L. Bennell Yuanyuan Wang Karine Fortin David J. Saxby Bryce A. Killen Tim V. Wrigley Flavia M. Cicuttini Ans Van Ginckel David G. Lloyd Julian A. Feller Christopher J. Vertullo Tim Whitehead Price Gallie Adam L. Bryant Patellar cartilage increase following ACL reconstruction with and without meniscal pathology: a two-year prospective MRI morphological study BMC Musculoskeletal Disorders Anterior cruciate ligament reconstruction Post-traumatic osteoarthritis Cartilage volume Cartilage defects Patellofemoral joint |
| title | Patellar cartilage increase following ACL reconstruction with and without meniscal pathology: a two-year prospective MRI morphological study |
| title_full | Patellar cartilage increase following ACL reconstruction with and without meniscal pathology: a two-year prospective MRI morphological study |
| title_fullStr | Patellar cartilage increase following ACL reconstruction with and without meniscal pathology: a two-year prospective MRI morphological study |
| title_full_unstemmed | Patellar cartilage increase following ACL reconstruction with and without meniscal pathology: a two-year prospective MRI morphological study |
| title_short | Patellar cartilage increase following ACL reconstruction with and without meniscal pathology: a two-year prospective MRI morphological study |
| title_sort | patellar cartilage increase following acl reconstruction with and without meniscal pathology a two year prospective mri morphological study |
| topic | Anterior cruciate ligament reconstruction Post-traumatic osteoarthritis Cartilage volume Cartilage defects Patellofemoral joint |
| url | https://doi.org/10.1186/s12891-021-04794-5 |
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