Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical Assessment
Dementia involves several factors, and it is required to administer an agent with several efficiencies for its treatment. Sake is known to have antioxidant and anti-inflammatory properties and improves the serum concentration of BDNF. This study aimed to evaluate the neuroprotective action of Japane...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | NeuroSci |
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| Online Access: | https://www.mdpi.com/2673-4087/4/1/6 |
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| author | Motahareh Haghipanah Fatemeh Ghalami Maryam Saadat Saeid Abbasi-Maleki Reza Hossein Gholizadeh Salmani Thomas Budde Nasrollah Moradikor |
| author_facet | Motahareh Haghipanah Fatemeh Ghalami Maryam Saadat Saeid Abbasi-Maleki Reza Hossein Gholizadeh Salmani Thomas Budde Nasrollah Moradikor |
| author_sort | Motahareh Haghipanah |
| collection | DOAJ |
| description | Dementia involves several factors, and it is required to administer an agent with several efficiencies for its treatment. Sake is known to have antioxidant and anti-inflammatory properties and improves the serum concentration of BDNF. This study aimed to evaluate the neuroprotective action of Japanese sake yeast on dementia of the Alzheimer disease type in rats by behavioral evaluation and neurobiochemical assessment. The rats were grouped as non-Alzheimer rats (control rats) and Alzheimer rats administrated with 0 (AD), 10 (10-AD), 20 (20-AD), 30 (30-AD), and 40 mg/kg (40-AD) of sake. Anxiety-like and depression-like behaviors, the concentrations of brain-derived neurotrophic factor (BDNF), malondialdehyde (MDA), and ferric reducing ability of plasma (FRAP) were evaluated. The expressions of IL-1β, TNF-α, and IL-6 were assessed. The results showed that Alzheimer disease caused anxiety-like and depression-like behaviors (<i>p</i> = 0.000), decreased the concentrations of BDNF (<i>p</i> = 0.000) and FRAP (<i>p</i> = 0.000), increased the concentration of MDA (<i>p</i> = 0.000), and increased the expressions of IL-1β (<i>p</i> = 0.000), TNF-α (<i>p</i> = 0.000), and IL-6 (<i>p</i> = 0.000). The results showed that oral gavage of sake in higher doses decreased anxiety-like and depression-like behaviors (<i>p</i> = 0.000), increased the concentrations of BDNF (<i>p</i> = 0.000) and FRAP (<i>p</i> = 0.000), and reduced the concentration of MDA (<i>p</i> = 0.000) and the expressions of IL-1β (<i>p</i> = 0.000), TNF-α (<i>p</i> = 0.000), and IL-6 (<i>p</i> = 0.000). In sum, Japanese sake yeast can have roles in treating dementia of the Alzheimer disease type, but its mechanisms must be assessed in future studies. |
| first_indexed | 2024-03-11T06:05:22Z |
| format | Article |
| id | doaj.art-a5cb063219874c02b8dadd575e0e4d6b |
| institution | Directory Open Access Journal |
| issn | 2673-4087 |
| language | English |
| last_indexed | 2024-03-11T06:05:22Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | NeuroSci |
| spelling | doaj.art-a5cb063219874c02b8dadd575e0e4d6b2023-11-17T13:02:48ZengMDPI AGNeuroSci2673-40872023-01-0141455310.3390/neurosci4010006Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical AssessmentMotahareh Haghipanah0Fatemeh Ghalami1Maryam Saadat2Saeid Abbasi-Maleki3Reza Hossein Gholizadeh Salmani4Thomas Budde5Nasrollah Moradikor6Department of Neuroscience Research, Institute for Intelligent Research, 0105 Tbilisi, GeorgiaRamsar International Branch, Mazandaran University of Medical Sciences, Sari 4691710001, IranDepartment of Anatomical Sciences, Faculty of Medicine, Semnan University of Medical Sciences, Semnan 3514799442, IranPharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6715847141, IranDepartment of Pathobiology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia P.O. Box 969, IranInstitut für Physiologie I, Westfälische Wilhelms-Universität, 48149 Münster, GermanyDepartment of Neuroscience Research, Institute for Intelligent Research, 0105 Tbilisi, GeorgiaDementia involves several factors, and it is required to administer an agent with several efficiencies for its treatment. Sake is known to have antioxidant and anti-inflammatory properties and improves the serum concentration of BDNF. This study aimed to evaluate the neuroprotective action of Japanese sake yeast on dementia of the Alzheimer disease type in rats by behavioral evaluation and neurobiochemical assessment. The rats were grouped as non-Alzheimer rats (control rats) and Alzheimer rats administrated with 0 (AD), 10 (10-AD), 20 (20-AD), 30 (30-AD), and 40 mg/kg (40-AD) of sake. Anxiety-like and depression-like behaviors, the concentrations of brain-derived neurotrophic factor (BDNF), malondialdehyde (MDA), and ferric reducing ability of plasma (FRAP) were evaluated. The expressions of IL-1β, TNF-α, and IL-6 were assessed. The results showed that Alzheimer disease caused anxiety-like and depression-like behaviors (<i>p</i> = 0.000), decreased the concentrations of BDNF (<i>p</i> = 0.000) and FRAP (<i>p</i> = 0.000), increased the concentration of MDA (<i>p</i> = 0.000), and increased the expressions of IL-1β (<i>p</i> = 0.000), TNF-α (<i>p</i> = 0.000), and IL-6 (<i>p</i> = 0.000). The results showed that oral gavage of sake in higher doses decreased anxiety-like and depression-like behaviors (<i>p</i> = 0.000), increased the concentrations of BDNF (<i>p</i> = 0.000) and FRAP (<i>p</i> = 0.000), and reduced the concentration of MDA (<i>p</i> = 0.000) and the expressions of IL-1β (<i>p</i> = 0.000), TNF-α (<i>p</i> = 0.000), and IL-6 (<i>p</i> = 0.000). In sum, Japanese sake yeast can have roles in treating dementia of the Alzheimer disease type, but its mechanisms must be assessed in future studies.https://www.mdpi.com/2673-4087/4/1/6AlzheimeranxietyantioxidantBDNFinflammation |
| spellingShingle | Motahareh Haghipanah Fatemeh Ghalami Maryam Saadat Saeid Abbasi-Maleki Reza Hossein Gholizadeh Salmani Thomas Budde Nasrollah Moradikor Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical Assessment NeuroSci Alzheimer anxiety antioxidant BDNF inflammation |
| title | Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical Assessment |
| title_full | Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical Assessment |
| title_fullStr | Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical Assessment |
| title_full_unstemmed | Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical Assessment |
| title_short | Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical Assessment |
| title_sort | investigation of the neuroprotective action of japanese sake yeast on dementia type of alzheimer disease in rats behavioral and neurobiochemical assessment |
| topic | Alzheimer anxiety antioxidant BDNF inflammation |
| url | https://www.mdpi.com/2673-4087/4/1/6 |
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