Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice

Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice

Abstract The SH3 and multiple ankyrin repeat domains 3 (Shank3) protein is a core organizer of the macromolecular complex in excitatory postsynapses, and its defects cause numerous synaptopathies, including autism spectrum disorders. Although the function of Shank3 as a postsynaptic scaffold is adeq...

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Bibliographic Details
Main Authors: Chunmei Jin, Yeunkum Lee, Hyojin Kang, Kwon Jeong, Joori Park, Yinhua Zhang, Hyae Rim Kang, Ruiying Ma, Hyunyoung Seong, Yoonhee Kim, Hosung Jung, Jin Young Kim, Yoon Ki Kim, Kihoon Han
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Brain
Subjects:
Shank3
Ribosomal protein
Protein synthesis
Striatum
Synaptosome
Online Access:https://doi.org/10.1186/s13041-021-00756-z

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