The Missing Piece: Recent Approaches Investigating the Antimicrobial Mode of Action of Essential Oils
Antibiotic resistance is a major global health issue that has seen alarming rates of increase in all parts of the world over the past two decades. The surge in antibiotic resistance has resulted in longer hospital stays, higher medical costs, and elevated mortality rates. Constant attempts have been...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-05-01
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| Series: | Evolutionary Bioinformatics |
| Online Access: | https://doi.org/10.1177/1176934320938391 |
| _version_ | 1818736408167186432 |
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| author | Shun-Kai Yang Ngai-Paing Tan Chun-Wie Chong Aisha Abushelaibi Swee-Hua-Erin Lim Kok-Song Lai |
| author_facet | Shun-Kai Yang Ngai-Paing Tan Chun-Wie Chong Aisha Abushelaibi Swee-Hua-Erin Lim Kok-Song Lai |
| author_sort | Shun-Kai Yang |
| collection | DOAJ |
| description | Antibiotic resistance is a major global health issue that has seen alarming rates of increase in all parts of the world over the past two decades. The surge in antibiotic resistance has resulted in longer hospital stays, higher medical costs, and elevated mortality rates. Constant attempts have been made to discover newer and more effective antimicrobials to reduce the severity of antibiotic resistance. Plant secondary metabolites, such as essential oils, have been the major focus due to their complexity and bioactive nature. However, the underlying mechanism of their antimicrobial effect remains largely unknown. Understanding the antimicrobial mode of action of essential oils is crucial in developing potential strategies for the use of essential oils in a clinical setting. Recent advances in genomics and proteomics have enhanced our understanding of the antimicrobial mode of action of essential oils. We might well be at the dawn of completing a mystery on how essential oils carry out their antimicrobial activities. Therefore, an overview of essential oils with regard to their antimicrobial activities and mode of action is discussed in this review. Recent approaches used in identifying the antimicrobial mode of action of essential oils, specifically from the perspective of genomics and proteomics, are also synthesized. Based on the information gathered from this review, we offer recommendations for future strategies and prospects for the study of essential oils and their function as antimicrobials. |
| first_indexed | 2024-12-18T00:36:40Z |
| format | Article |
| id | doaj.art-a5d01e95dfb94e449a6e6a66b30e3800 |
| institution | Directory Open Access Journal |
| issn | 1176-9343 |
| language | English |
| last_indexed | 2024-12-18T00:36:40Z |
| publishDate | 2021-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Evolutionary Bioinformatics |
| spelling | doaj.art-a5d01e95dfb94e449a6e6a66b30e38002022-12-21T21:27:00ZengSAGE PublishingEvolutionary Bioinformatics1176-93432021-05-011710.1177/1176934320938391The Missing Piece: Recent Approaches Investigating the Antimicrobial Mode of Action of Essential OilsShun-Kai Yang0Ngai-Paing Tan1Chun-Wie Chong2Aisha Abushelaibi3Swee-Hua-Erin Lim4Kok-Song Lai5Health Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi, United Arab EmiratesDepartment of Land Management, Faculty of Agriculture, Universiti Putra Malaysia, Selangor, MalaysiaSchool of Pharmacy, Monash University Malaysia, Subang Jaya, MalaysiaHealth Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi, United Arab EmiratesHealth Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi, United Arab EmiratesHealth Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi, United Arab EmiratesAntibiotic resistance is a major global health issue that has seen alarming rates of increase in all parts of the world over the past two decades. The surge in antibiotic resistance has resulted in longer hospital stays, higher medical costs, and elevated mortality rates. Constant attempts have been made to discover newer and more effective antimicrobials to reduce the severity of antibiotic resistance. Plant secondary metabolites, such as essential oils, have been the major focus due to their complexity and bioactive nature. However, the underlying mechanism of their antimicrobial effect remains largely unknown. Understanding the antimicrobial mode of action of essential oils is crucial in developing potential strategies for the use of essential oils in a clinical setting. Recent advances in genomics and proteomics have enhanced our understanding of the antimicrobial mode of action of essential oils. We might well be at the dawn of completing a mystery on how essential oils carry out their antimicrobial activities. Therefore, an overview of essential oils with regard to their antimicrobial activities and mode of action is discussed in this review. Recent approaches used in identifying the antimicrobial mode of action of essential oils, specifically from the perspective of genomics and proteomics, are also synthesized. Based on the information gathered from this review, we offer recommendations for future strategies and prospects for the study of essential oils and their function as antimicrobials.https://doi.org/10.1177/1176934320938391 |
| spellingShingle | Shun-Kai Yang Ngai-Paing Tan Chun-Wie Chong Aisha Abushelaibi Swee-Hua-Erin Lim Kok-Song Lai The Missing Piece: Recent Approaches Investigating the Antimicrobial Mode of Action of Essential Oils Evolutionary Bioinformatics |
| title | The Missing Piece: Recent Approaches Investigating the Antimicrobial Mode of Action of Essential Oils |
| title_full | The Missing Piece: Recent Approaches Investigating the Antimicrobial Mode of Action of Essential Oils |
| title_fullStr | The Missing Piece: Recent Approaches Investigating the Antimicrobial Mode of Action of Essential Oils |
| title_full_unstemmed | The Missing Piece: Recent Approaches Investigating the Antimicrobial Mode of Action of Essential Oils |
| title_short | The Missing Piece: Recent Approaches Investigating the Antimicrobial Mode of Action of Essential Oils |
| title_sort | missing piece recent approaches investigating the antimicrobial mode of action of essential oils |
| url | https://doi.org/10.1177/1176934320938391 |
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