Diffusion-Weighted Magnetic Resonance Imaging of the Brain in Multiple Sclerosis
OBJECTIVE: MRI. Diffusion-weighted MRI (DW-MRI) offers the possibility of differentiating such lesions from ischaemic lesions by using objective data as well as determining active MS plaque in particular. OBJECTIVES: This present study investigated diffusion alterations in MS patients in plaques a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2007-10-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-83997 |
| Summary: | OBJECTIVE: MRI. Diffusion-weighted MRI (DW-MRI) offers the possibility of differentiating such lesions from ischaemic lesions by using objective data as well as determining active MS plaque in particular.
OBJECTIVES: This present study investigated diffusion alterations in MS patients in plaques and the normal-appearing white matter.
METHODS: A total of 45 patients had been diagnosed with MS according to Mc Donald’s criteria were enrolled in the study. Cranial MRI examination consisted of number of lesions in PD/T2 transverse, T2 sagittal, T2 FLAIR transverse, diffusion-weighted MRI and ADC mapping, heavy IR-T1 transverse, T1 transverse, postcontrast T1 transverse imaging, incidence ratio in all sequences as well as assessment of contrasting characteristics. Visual characteristics of the lesions were determined in diffusion-weighted MRI and ADC mapping.
RESULTS: Mean ADC values measured in the normal appearing white matter according to clinical forms were as follows: 0.79 ± 0.15x10-3 mm2/sec for RRMS, 0.8 ± 0.15x10-3 mm2/sec PPMS and 0.82 ± 0.15x10-3 mm2/sec for SPMS. The differences between clinical forms in terms of mean ADC values measured in the normal appearing white matter were statistically significant (p<0.05). Mean ADC values measured in T1 isointense lesions were O.97 ± 0.15x10-3 mm2/sec for RRMS, 0.98 ± 0.15x10-3 mm2/sec for PPMS and 0.99 ± 0.15x10-3 mm2/sec for SPMS. The differences between the groups were not statistically significant (p>0.05). Mean ADC values measured in T1 hypointense lesions were 1.106 ± 0.15x10-3 mm2/sec for RRMS, 1.119 ± 0.15x10-3 mm2/sec for PPMS and 1.132 ± 0.15x10-3 mm2/sec for SPMS. The differences between the groups were statistically significant (p<0.05).
CONCLUSION: DW-MRI revealed increased diffusion in chronic lesions, acute lesions and normal-appearing white matter in all patients in this present study. Mean ADC value established in acute lesions was 1.062± 0.15x10-3 mm2/sec, while it was 1.118 ± 0,15x10-3 mm2/sec in T1 hypointense lesions and 0.985 ± 0.12x10-3 mm2/sec in T1 isointense lesions. Significantly higher ADC values in T1 hypointense lesions and acute lesions indicated more severe tissue damage in those lesions |
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| ISSN: | 1301-062X 1309-2545 |