Generation of multicellular tumor spheroids with micro-well array for anticancer drug combination screening based on a valuable biomarker of hepatocellular carcinoma

Generation of multicellular tumor spheroids with micro-well array for anticancer drug combination screening based on a valuable biomarker of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a highly malignant tumor with a poor prognosis. More than 30% of patients with diagnosed HCC have abnormally high expression of fibroblast growth factor receptor 4 (FGFR4). Currently, clinical trials for a variety of FGFR4-specific inhibitors have started. However,...

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Bibliographic Details
Main Authors: Qi Wang, Juan Liu, Wenzhen Yin, Dawei Sun, Zhongsong Man, Shangwei Jiang, Xiufeng Ran, Yuxin Su, Yunfang Wang, Jiahong Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hepatocellular carcinoma
FGFR4 specific inhibitors
drug combination
3D cell culture
parthenolide
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1087656/full

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