Metabolomics of Head and Neck Cancer: A Mini-Review
Metabolomics is used in systems biology to enhance the understanding of complex disease processes, such as cancer. Head and neck cancer (HNC) is an epithelial malignancy that arises in the upper aerodigestive tract and affects more than half a million people worldwide each year. Recently, significan...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00526/full |
| _version_ | 1811274828727975936 |
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| author | Jae M Shin Jae M Shin Pachiyappan Kamarajan Pachiyappan Kamarajan J Christopher Fenno Alexander Hammond Rickard Yvonne Lorraine Kapila Yvonne Lorraine Kapila |
| author_facet | Jae M Shin Jae M Shin Pachiyappan Kamarajan Pachiyappan Kamarajan J Christopher Fenno Alexander Hammond Rickard Yvonne Lorraine Kapila Yvonne Lorraine Kapila |
| author_sort | Jae M Shin |
| collection | DOAJ |
| description | Metabolomics is used in systems biology to enhance the understanding of complex disease processes, such as cancer. Head and neck cancer (HNC) is an epithelial malignancy that arises in the upper aerodigestive tract and affects more than half a million people worldwide each year. Recently, significant effort has focused on integrating multiple ‘omics’ technologies for oncological research. In particular, research has been focused on identifying tumor-specific metabolite profiles using different sample types (biological fluids, cells and tissues) and a variety of metabolomic platforms and technologies. With our current understanding of molecular abnormalities of HNC, the addition of metabolomic studies will enhance our knowledge of the pathogenesis of this disease and potentially aid in the development of novel strategies to prevent and treat HNC. In this review, we summarize the proposed hypotheses and conclusions from publications that reported findings on the metabolomics of HNC. In addition, we address the potential influence of host-microbe metabolomics in cancer. From a systems biology perspective, the integrative use of genomics, transcriptomics and proteomics will be extremely important for future translational metabolomic-based research discoveries. |
| first_indexed | 2024-04-12T23:26:24Z |
| format | Article |
| id | doaj.art-a5d23e4c61644e4ba422f559c3f51ab4 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T23:26:24Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-a5d23e4c61644e4ba422f559c3f51ab42022-12-22T03:12:24ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2016-11-01710.3389/fphys.2016.00526223685Metabolomics of Head and Neck Cancer: A Mini-ReviewJae M Shin0Jae M Shin1Pachiyappan Kamarajan2Pachiyappan Kamarajan3J Christopher Fenno4Alexander Hammond Rickard5Yvonne Lorraine Kapila6Yvonne Lorraine Kapila7University of Michigan School of DentistryUniversity of Michigan School of Public HealthUniversity of California San Francisco, School of DentistryUniversity of Michigan School of DentistryUniversity of Michigan School of DentistryUniversity of Michigan School of Public HealthUniversity of California San Francisco, School of DentistryUniversity of Michigan School of DentistryMetabolomics is used in systems biology to enhance the understanding of complex disease processes, such as cancer. Head and neck cancer (HNC) is an epithelial malignancy that arises in the upper aerodigestive tract and affects more than half a million people worldwide each year. Recently, significant effort has focused on integrating multiple ‘omics’ technologies for oncological research. In particular, research has been focused on identifying tumor-specific metabolite profiles using different sample types (biological fluids, cells and tissues) and a variety of metabolomic platforms and technologies. With our current understanding of molecular abnormalities of HNC, the addition of metabolomic studies will enhance our knowledge of the pathogenesis of this disease and potentially aid in the development of novel strategies to prevent and treat HNC. In this review, we summarize the proposed hypotheses and conclusions from publications that reported findings on the metabolomics of HNC. In addition, we address the potential influence of host-microbe metabolomics in cancer. From a systems biology perspective, the integrative use of genomics, transcriptomics and proteomics will be extremely important for future translational metabolomic-based research discoveries.http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00526/fullMetabolomicsSquamous cell carcinomamicrobiomeoral cancerhead and neck cancer |
| spellingShingle | Jae M Shin Jae M Shin Pachiyappan Kamarajan Pachiyappan Kamarajan J Christopher Fenno Alexander Hammond Rickard Yvonne Lorraine Kapila Yvonne Lorraine Kapila Metabolomics of Head and Neck Cancer: A Mini-Review Frontiers in Physiology Metabolomics Squamous cell carcinoma microbiome oral cancer head and neck cancer |
| title | Metabolomics of Head and Neck Cancer: A Mini-Review |
| title_full | Metabolomics of Head and Neck Cancer: A Mini-Review |
| title_fullStr | Metabolomics of Head and Neck Cancer: A Mini-Review |
| title_full_unstemmed | Metabolomics of Head and Neck Cancer: A Mini-Review |
| title_short | Metabolomics of Head and Neck Cancer: A Mini-Review |
| title_sort | metabolomics of head and neck cancer a mini review |
| topic | Metabolomics Squamous cell carcinoma microbiome oral cancer head and neck cancer |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00526/full |
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