Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal Model
The diabetic wounds are one of the global burden diseases. In our previous study, Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1% combination gel preparation showed remarkable wound healing effectivi...
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| Format: | Article |
| Language: | English |
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Universitas Sanata Dharma
2023-05-01
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| Series: | Jurnal Farmasi Sains dan Komunitas |
| Subjects: | |
| Online Access: | https://e-journal.usd.ac.id/index.php/JFSK/article/view/3319 |
| _version_ | 1797785745679712256 |
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| author | Sarah Sahila Hendy Suhendy Yedy Purwandi Sukmawan |
| author_facet | Sarah Sahila Hendy Suhendy Yedy Purwandi Sukmawan |
| author_sort | Sarah Sahila |
| collection | DOAJ |
| description | The diabetic wounds are one of the global burden diseases. In our previous study, Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1% combination gel preparation showed remarkable wound healing effectivity. However, this wound healing effectivity in the diabetic condition is still unknown. There were three groups used, namely negative group (placebo/gel base), positive group (oxoferin/tetrachlorodecaoxide), and test group (Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1%). Each group consisted of three male Wistar rats. We conducted diabetes induction with alloxan (175 mg/Kg BW i.p) and followed by an incision 1.5 cm on the back. All of these groups were given treatment once daily and monitored for 14 days. The results of the study showed the test group indicated significantly better effectivity than positive and negative groups (p0.05). The percentages of the wound healing effectivity of the test, positive and negative groups were 62.74%, 51.77%, and 41.65%, respectively. Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1% combination gel preparation has excellent potential to be developed as a commercial product to treat diabetic wound conditions.
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| first_indexed | 2024-03-13T00:59:15Z |
| format | Article |
| id | doaj.art-a5d3bdb11f5e472caca34805675e9de7 |
| institution | Directory Open Access Journal |
| issn | 1693-5683 2527-7146 |
| language | English |
| last_indexed | 2024-03-13T00:59:15Z |
| publishDate | 2023-05-01 |
| publisher | Universitas Sanata Dharma |
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| series | Jurnal Farmasi Sains dan Komunitas |
| spelling | doaj.art-a5d3bdb11f5e472caca34805675e9de72023-07-06T13:56:39ZengUniversitas Sanata DharmaJurnal Farmasi Sains dan Komunitas1693-56832527-71462023-05-01201788310.24071/jpsc.0033192954Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal ModelSarah Sahila0Hendy Suhendy1Yedy Purwandi Sukmawan2Department of Pharmacology and Clinical Pharmacy, Bakti Tunas Husada Health Science College, Cilolohan Street No. 36, Tasikmalaya, 46184, West Java, Indonesia.Department of Pharmacognosy, Bakti Tunas Husada Health Science College, Cilolohan Street No. 36, Tasikmalaya, 46184, West Java, IndonesiaBakti Tunas Husada Health Science CollegeThe diabetic wounds are one of the global burden diseases. In our previous study, Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1% combination gel preparation showed remarkable wound healing effectivity. However, this wound healing effectivity in the diabetic condition is still unknown. There were three groups used, namely negative group (placebo/gel base), positive group (oxoferin/tetrachlorodecaoxide), and test group (Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1%). Each group consisted of three male Wistar rats. We conducted diabetes induction with alloxan (175 mg/Kg BW i.p) and followed by an incision 1.5 cm on the back. All of these groups were given treatment once daily and monitored for 14 days. The results of the study showed the test group indicated significantly better effectivity than positive and negative groups (p0.05). The percentages of the wound healing effectivity of the test, positive and negative groups were 62.74%, 51.77%, and 41.65%, respectively. Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1% combination gel preparation has excellent potential to be developed as a commercial product to treat diabetic wound conditions. .https://e-journal.usd.ac.id/index.php/JFSK/article/view/3319ageratum conyzoidesastaxanthincentella asiaticadiabeticwound healing |
| spellingShingle | Sarah Sahila Hendy Suhendy Yedy Purwandi Sukmawan Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal Model Jurnal Farmasi Sains dan Komunitas ageratum conyzoides astaxanthin centella asiatica diabetic wound healing |
| title | Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal Model |
| title_full | Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal Model |
| title_fullStr | Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal Model |
| title_full_unstemmed | Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal Model |
| title_short | Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal Model |
| title_sort | wound healing effectivity of ageratum conyzoides l leaf ethanolic extract purple flower type centella asiatica l urban leaf ethanolic extract and astaxanthin combination gel preparation in diabetic animal model |
| topic | ageratum conyzoides astaxanthin centella asiatica diabetic wound healing |
| url | https://e-journal.usd.ac.id/index.php/JFSK/article/view/3319 |
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