Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles
Biodegradable poly(lactic-co-glycolic acid) copolymer, PLGA nanoparticles (NPs) with a surface layer of poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, Pluronics, are promising drug carrier systems. With the aim to increase the potential of targeted drug deliver...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Budapest University of Technology
2016-03-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0006526&mi=cd |
| _version_ | 1818392472227676160 |
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| author | G. Gyulai A. Magyar J. Rohonczy J. Orosz M. Yamasaki Sz. Bosze E. Kiss |
| author_facet | G. Gyulai A. Magyar J. Rohonczy J. Orosz M. Yamasaki Sz. Bosze E. Kiss |
| author_sort | G. Gyulai |
| collection | DOAJ |
| description | Biodegradable poly(lactic-co-glycolic acid) copolymer, PLGA nanoparticles (NPs) with a surface layer of poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, Pluronics, are promising drug carrier systems. With the aim to increase the potential of targeted drug delivery the end group derivative of Pluronics was synthesized in a straightforward way to obtain Pluronic-amines. The formation of functional amine groups was confirmed by fluorescamine method and NMR analysis of their N-(tert-Butoxycarbonyl)-L-phenylalanine (Boc-Phe-OH) and N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine (Fmoc-Phe-OH) conjugates. Pluronic and Pluronic-amine stabilized PLGA NPs prepared by nanoprecipitation were characterized by dynamic light scattering and zeta potential measurements. All of the systems showed high colloidal stability checked by electrolyte induced aggregation, although the presence of Pluronicamine on the surface decreased the zeta potential in some extent. The introduction of reactive primary amine groups into the surface layer of PLGA NPs while preserving the aggregation stability, provides a possibility for coupling of various ligands allowing targeted delivery and also contributes to the improved membrane affinity of NPs. |
| first_indexed | 2024-12-14T05:29:57Z |
| format | Article |
| id | doaj.art-a5d7d0fe746d4881ab17ddb355bc2e6c |
| institution | Directory Open Access Journal |
| issn | 1788-618X |
| language | English |
| last_indexed | 2024-12-14T05:29:57Z |
| publishDate | 2016-03-01 |
| publisher | Budapest University of Technology |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj.art-a5d7d0fe746d4881ab17ddb355bc2e6c2022-12-21T23:15:22ZengBudapest University of TechnologyeXPRESS Polymer Letters1788-618X2016-03-0110321622610.3144/expresspolymlett.2016.20Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticlesG. GyulaiA. MagyarJ. RohonczyJ. OroszM. YamasakiSz. BoszeE. KissBiodegradable poly(lactic-co-glycolic acid) copolymer, PLGA nanoparticles (NPs) with a surface layer of poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, Pluronics, are promising drug carrier systems. With the aim to increase the potential of targeted drug delivery the end group derivative of Pluronics was synthesized in a straightforward way to obtain Pluronic-amines. The formation of functional amine groups was confirmed by fluorescamine method and NMR analysis of their N-(tert-Butoxycarbonyl)-L-phenylalanine (Boc-Phe-OH) and N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine (Fmoc-Phe-OH) conjugates. Pluronic and Pluronic-amine stabilized PLGA NPs prepared by nanoprecipitation were characterized by dynamic light scattering and zeta potential measurements. All of the systems showed high colloidal stability checked by electrolyte induced aggregation, although the presence of Pluronicamine on the surface decreased the zeta potential in some extent. The introduction of reactive primary amine groups into the surface layer of PLGA NPs while preserving the aggregation stability, provides a possibility for coupling of various ligands allowing targeted delivery and also contributes to the improved membrane affinity of NPs.http://www.expresspolymlett.com/letolt.php?file=EPL-0006526&mi=cdBiodegradable polymersPluronic derivatizationPLGA nanoparticlesPeptide conjugationPolymeric drug delivery |
| spellingShingle | G. Gyulai A. Magyar J. Rohonczy J. Orosz M. Yamasaki Sz. Bosze E. Kiss Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles eXPRESS Polymer Letters Biodegradable polymers Pluronic derivatization PLGA nanoparticles Peptide conjugation Polymeric drug delivery |
| title | Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles |
| title_full | Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles |
| title_fullStr | Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles |
| title_full_unstemmed | Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles |
| title_short | Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles |
| title_sort | preparation and characterization of cationic pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles |
| topic | Biodegradable polymers Pluronic derivatization PLGA nanoparticles Peptide conjugation Polymeric drug delivery |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0006526&mi=cd |
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