A Review of Cold Atmospheric Pressure Plasmas for Trauma and Acute Care
Despite the high overall survival rates of severely injured military and civilian personnel requiring trauma and acute care, the challenges of treating infections and healing-resistant wounds have grown. Exposure to unknown environmental pathogens at the wound, including parasites and antibiotic res...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Physics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphy.2021.786381/full |
| _version_ | 1818974065123131392 |
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| author | Allen L. Garner Allen L. Garner Allen L. Garner Allen L. Garner Thomas A. Mehlhorn |
| author_facet | Allen L. Garner Allen L. Garner Allen L. Garner Allen L. Garner Thomas A. Mehlhorn |
| author_sort | Allen L. Garner |
| collection | DOAJ |
| description | Despite the high overall survival rates of severely injured military and civilian personnel requiring trauma and acute care, the challenges of treating infections and healing-resistant wounds have grown. Exposure to unknown environmental pathogens at the wound, including parasites and antibiotic resistant microorganisms, hinders timely and effective treatment using traditional techniques. Cold atmospheric pressure plasma (CAPP) provides a promising biophysical tool to address these issues by applying physically created modalities that cannot be circumvented by bioresistance to inactivate microorganisms and enhance wound healing. CAPPs generate charged particles and numerous reactive oxygen species (ROS) and reactive nitrogen species (RNS) that act on biological cells and tissues, often through plasma membrane interactions. This review fills a gap in the plasma medicine literature by specifically focusing on applying CAPPs for acute trauma, such as surgery, wound treatment, and disinfection. After briefly highlighting the areas of opportunity for improving acute trauma treatment and the fundamentals of CAPP generation, this review details emerging applications of CAPPs for enhanced wound healing, burn treatment, transdermal delivery, and surgical applications. We also discuss CAPP optimization through novel device design and synergistic combination with traditional treatment technologies to transition this biophysical technology to the battlefield and acute care settings. |
| first_indexed | 2024-12-20T15:34:08Z |
| format | Article |
| id | doaj.art-a5d7e38420ab45a6bba3a1479e3ee502 |
| institution | Directory Open Access Journal |
| issn | 2296-424X |
| language | English |
| last_indexed | 2024-12-20T15:34:08Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physics |
| spelling | doaj.art-a5d7e38420ab45a6bba3a1479e3ee5022022-12-21T19:35:31ZengFrontiers Media S.A.Frontiers in Physics2296-424X2021-12-01910.3389/fphy.2021.786381786381A Review of Cold Atmospheric Pressure Plasmas for Trauma and Acute CareAllen L. Garner0Allen L. Garner1Allen L. Garner2Allen L. Garner3Thomas A. Mehlhorn4Office of Naval Research, Arlington, VA, United StatesSchool of Nuclear Engineering, Purdue University, West Lafayette, IN, United StatesElmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United StatesDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, United StatesMehlhorn Engineering Consulting Services, Beaverton, OR, United StatesDespite the high overall survival rates of severely injured military and civilian personnel requiring trauma and acute care, the challenges of treating infections and healing-resistant wounds have grown. Exposure to unknown environmental pathogens at the wound, including parasites and antibiotic resistant microorganisms, hinders timely and effective treatment using traditional techniques. Cold atmospheric pressure plasma (CAPP) provides a promising biophysical tool to address these issues by applying physically created modalities that cannot be circumvented by bioresistance to inactivate microorganisms and enhance wound healing. CAPPs generate charged particles and numerous reactive oxygen species (ROS) and reactive nitrogen species (RNS) that act on biological cells and tissues, often through plasma membrane interactions. This review fills a gap in the plasma medicine literature by specifically focusing on applying CAPPs for acute trauma, such as surgery, wound treatment, and disinfection. After briefly highlighting the areas of opportunity for improving acute trauma treatment and the fundamentals of CAPP generation, this review details emerging applications of CAPPs for enhanced wound healing, burn treatment, transdermal delivery, and surgical applications. We also discuss CAPP optimization through novel device design and synergistic combination with traditional treatment technologies to transition this biophysical technology to the battlefield and acute care settings.https://www.frontiersin.org/articles/10.3389/fphy.2021.786381/fullplasma medicinereactive specieswound healingmicroorganism inactivationdielectric barrier dischargeplasma jets |
| spellingShingle | Allen L. Garner Allen L. Garner Allen L. Garner Allen L. Garner Thomas A. Mehlhorn A Review of Cold Atmospheric Pressure Plasmas for Trauma and Acute Care Frontiers in Physics plasma medicine reactive species wound healing microorganism inactivation dielectric barrier discharge plasma jets |
| title | A Review of Cold Atmospheric Pressure Plasmas for Trauma and Acute Care |
| title_full | A Review of Cold Atmospheric Pressure Plasmas for Trauma and Acute Care |
| title_fullStr | A Review of Cold Atmospheric Pressure Plasmas for Trauma and Acute Care |
| title_full_unstemmed | A Review of Cold Atmospheric Pressure Plasmas for Trauma and Acute Care |
| title_short | A Review of Cold Atmospheric Pressure Plasmas for Trauma and Acute Care |
| title_sort | review of cold atmospheric pressure plasmas for trauma and acute care |
| topic | plasma medicine reactive species wound healing microorganism inactivation dielectric barrier discharge plasma jets |
| url | https://www.frontiersin.org/articles/10.3389/fphy.2021.786381/full |
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