Effects of physical exercise on the functionality of human nucleotidases: A systematic review
Abstract Nucleotidases contribute to the regulation of inflammation, coagulation, and cardiovascular activity. Exercise promotes biological adaptations, but its effects on nucleotidase activities and expression are unclear. The objective of this study was to review systematically the effects of exer...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15464 |
| _version_ | 1811204267731582976 |
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| author | Cesar Eduardo Jacintho Moritz Alexandra Ferreira Vieira Denise deMelo‐Marins Fabrício Figueiró Ana Maria Oliveira Battastini Alvaro Reischak‐Oliveira |
| author_facet | Cesar Eduardo Jacintho Moritz Alexandra Ferreira Vieira Denise deMelo‐Marins Fabrício Figueiró Ana Maria Oliveira Battastini Alvaro Reischak‐Oliveira |
| author_sort | Cesar Eduardo Jacintho Moritz |
| collection | DOAJ |
| description | Abstract Nucleotidases contribute to the regulation of inflammation, coagulation, and cardiovascular activity. Exercise promotes biological adaptations, but its effects on nucleotidase activities and expression are unclear. The objective of this study was to review systematically the effects of exercise on nucleotidase functionality in healthy and unhealthy subjects. The MEDLINE, EMBASE, Cochrane Library, and Web of Science databases were searched to identify, randomized clinical trials, non‐randomized clinical trials, uncontrolled clinical trials, quasi‐experimental, pre‐, and post‐interventional studies that evaluated the effects of exercise on nucleotidases in humans, and was not limited by language and date. Two independent reviewers performed the study selection, data extraction, and assessment of risk of bias. Of the 203 articles identified, 12 were included in this review. Eight studies reported that acute exercise, in healthy and unhealthy subjects, elevated the activities or expression of nucleotidases. Four studies evaluated the effects of chronic training on nucleotidase activities in the platelets and lymphocytes of patients with metabolic syndrome, chronic kidney disease, and hypertension and found a decrease in nucleotidase activities in these conditions. Acute and chronic exercise was able to modify the blood plasma and serum levels of nucleotides and nucleosides. Our results suggest that short‐ and long‐term exercise modulate nucleotidase functionality. As such, purinergic signaling may represent a novel molecular adaptation in inflammatory, thrombotic, and vascular responses to exercise. |
| first_indexed | 2024-04-12T03:09:45Z |
| format | Article |
| id | doaj.art-a5d8260231f44f53b9e34ed76b5b0e8b |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-04-12T03:09:45Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-a5d8260231f44f53b9e34ed76b5b0e8b2022-12-22T03:50:24ZengWileyPhysiological Reports2051-817X2022-09-011018n/an/a10.14814/phy2.15464Effects of physical exercise on the functionality of human nucleotidases: A systematic reviewCesar Eduardo Jacintho Moritz0Alexandra Ferreira Vieira1Denise deMelo‐Marins2Fabrício Figueiró3Ana Maria Oliveira Battastini4Alvaro Reischak‐Oliveira5Programa de Pós‐Graduação em Ciências do Movimento Humano, Escola de Educação Física, Fisioterapia e Dança (ESEFID) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre BrazilPrograma de Pós‐Graduação em Ciências do Movimento Humano, Escola de Educação Física, Fisioterapia e Dança (ESEFID) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre BrazilPrograma de Pós‐Graduação em Ciências do Movimento Humano, Escola de Educação Física, Fisioterapia e Dança (ESEFID) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre BrazilPrograma de Pós‐Graduação em Ciências Biológicas: Bioquímica Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre BrazilPrograma de Pós‐Graduação em Ciências Biológicas: Bioquímica Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre BrazilPrograma de Pós‐Graduação em Ciências do Movimento Humano, Escola de Educação Física, Fisioterapia e Dança (ESEFID) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre BrazilAbstract Nucleotidases contribute to the regulation of inflammation, coagulation, and cardiovascular activity. Exercise promotes biological adaptations, but its effects on nucleotidase activities and expression are unclear. The objective of this study was to review systematically the effects of exercise on nucleotidase functionality in healthy and unhealthy subjects. The MEDLINE, EMBASE, Cochrane Library, and Web of Science databases were searched to identify, randomized clinical trials, non‐randomized clinical trials, uncontrolled clinical trials, quasi‐experimental, pre‐, and post‐interventional studies that evaluated the effects of exercise on nucleotidases in humans, and was not limited by language and date. Two independent reviewers performed the study selection, data extraction, and assessment of risk of bias. Of the 203 articles identified, 12 were included in this review. Eight studies reported that acute exercise, in healthy and unhealthy subjects, elevated the activities or expression of nucleotidases. Four studies evaluated the effects of chronic training on nucleotidase activities in the platelets and lymphocytes of patients with metabolic syndrome, chronic kidney disease, and hypertension and found a decrease in nucleotidase activities in these conditions. Acute and chronic exercise was able to modify the blood plasma and serum levels of nucleotides and nucleosides. Our results suggest that short‐ and long‐term exercise modulate nucleotidase functionality. As such, purinergic signaling may represent a novel molecular adaptation in inflammatory, thrombotic, and vascular responses to exercise.https://doi.org/10.14814/phy2.154645′‐nucleotidaseexerciseNTPDase1Nucleotidases |
| spellingShingle | Cesar Eduardo Jacintho Moritz Alexandra Ferreira Vieira Denise deMelo‐Marins Fabrício Figueiró Ana Maria Oliveira Battastini Alvaro Reischak‐Oliveira Effects of physical exercise on the functionality of human nucleotidases: A systematic review Physiological Reports 5′‐nucleotidase exercise NTPDase1 Nucleotidases |
| title | Effects of physical exercise on the functionality of human nucleotidases: A systematic review |
| title_full | Effects of physical exercise on the functionality of human nucleotidases: A systematic review |
| title_fullStr | Effects of physical exercise on the functionality of human nucleotidases: A systematic review |
| title_full_unstemmed | Effects of physical exercise on the functionality of human nucleotidases: A systematic review |
| title_short | Effects of physical exercise on the functionality of human nucleotidases: A systematic review |
| title_sort | effects of physical exercise on the functionality of human nucleotidases a systematic review |
| topic | 5′‐nucleotidase exercise NTPDase1 Nucleotidases |
| url | https://doi.org/10.14814/phy2.15464 |
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