XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
Endometrial carcinoma’s (EC) etiology is complex and involves DNA repair gene polymorphisms like XRCC1-Arg399Gln and hOGG1-Ser326Cys, but their association with the disease is unclear. Following PRISMA, we conducted a systematic review and meta-analysis, collecting data from four databases. The stud...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-03-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2024-0913 |
| _version_ | 1797266162712576000 |
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| author | He Shengke Zhao Xiujuan Mu Ruifang Pan Zhongjun Mai Jinglan |
| author_facet | He Shengke Zhao Xiujuan Mu Ruifang Pan Zhongjun Mai Jinglan |
| author_sort | He Shengke |
| collection | DOAJ |
| description | Endometrial carcinoma’s (EC) etiology is complex and involves DNA repair gene polymorphisms like XRCC1-Arg399Gln and hOGG1-Ser326Cys, but their association with the disease is unclear. Following PRISMA, we conducted a systematic review and meta-analysis, collecting data from four databases. The studies needed to be population-based case–control studies examining the association between the named polymorphisms and EC. Quality was assessed with the Newcastle-Ottawa Scale. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated, and subgroup analyses were conducted based on ethnicity. Seven studies were included. Both polymorphisms were found to significantly increase EC risk, particularly in Caucasians. XRCC1-Arg399Gln showed a dominant model OR of 1.14 (95% CI: 1.01–1.29) and a homozygous model OR of 1.59 (95% CI: 1.12–2.25). The heterozygote model OR for hOGG1-Ser326Cys was 1.29 (95% CI: 1.02–1.63), and the allele OR was 1.31 (95% CI: 1.07–1.60). XRCC1-Arg399Gln and hOGG1-Ser326Cys may increase EC risk, primarily in Caucasian women, emphasizing the role of DNA repair in disease susceptibility. More extensive studies are needed to validate these findings in diverse ethnicities and investigate other DNA repair gene polymorphisms. |
| first_indexed | 2024-04-25T00:56:19Z |
| format | Article |
| id | doaj.art-a5d8e01c70c74a22bf74b26582687e13 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-25T00:56:19Z |
| publishDate | 2024-03-01 |
| publisher | De Gruyter |
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| spelling | doaj.art-a5d8e01c70c74a22bf74b26582687e132024-03-11T10:04:38ZengDe GruyterOpen Medicine2391-54632024-03-0119114081510.1515/med-2024-0913XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysisHe Shengke0Zhao Xiujuan1Mu Ruifang2Pan Zhongjun3Mai Jinglan4Department of Pathology, Danzhou People’s Hospital, Nada Town, Danzhou, Hainan, 571799, ChinaDepartment of Gynaecology and Obstetrics, Danzhou People’s Hospital, Nada Town, Danzhou, Hainan, 571799, ChinaDepartment of Gynaecology and Obstetrics, Danzhou People’s Hospital, Nada Town, Danzhou, Hainan, 571799, ChinaDepartment of Pathology, Danzhou People’s Hospital, Nada Town, Danzhou, Hainan, 571799, ChinaOccupational Physical Examination Outpatient, Haikou Center for Disease Control and Prevention, No. 56 Yehai Avenue, Qiongshan District, Haikou, Hainan, 570203, ChinaEndometrial carcinoma’s (EC) etiology is complex and involves DNA repair gene polymorphisms like XRCC1-Arg399Gln and hOGG1-Ser326Cys, but their association with the disease is unclear. Following PRISMA, we conducted a systematic review and meta-analysis, collecting data from four databases. The studies needed to be population-based case–control studies examining the association between the named polymorphisms and EC. Quality was assessed with the Newcastle-Ottawa Scale. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated, and subgroup analyses were conducted based on ethnicity. Seven studies were included. Both polymorphisms were found to significantly increase EC risk, particularly in Caucasians. XRCC1-Arg399Gln showed a dominant model OR of 1.14 (95% CI: 1.01–1.29) and a homozygous model OR of 1.59 (95% CI: 1.12–2.25). The heterozygote model OR for hOGG1-Ser326Cys was 1.29 (95% CI: 1.02–1.63), and the allele OR was 1.31 (95% CI: 1.07–1.60). XRCC1-Arg399Gln and hOGG1-Ser326Cys may increase EC risk, primarily in Caucasian women, emphasizing the role of DNA repair in disease susceptibility. More extensive studies are needed to validate these findings in diverse ethnicities and investigate other DNA repair gene polymorphisms.https://doi.org/10.1515/med-2024-0913xrcc1-arg399glnhogg1-ser326cysendometrial carcinomapolymorphismmeta-analysisgenetic susceptibility |
| spellingShingle | He Shengke Zhao Xiujuan Mu Ruifang Pan Zhongjun Mai Jinglan XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis Open Medicine xrcc1-arg399gln hogg1-ser326cys endometrial carcinoma polymorphism meta-analysis genetic susceptibility |
| title | XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis |
| title_full | XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis |
| title_fullStr | XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis |
| title_full_unstemmed | XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis |
| title_short | XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis |
| title_sort | xrcc1 and hogg1 polymorphisms and endometrial carcinoma a meta analysis |
| topic | xrcc1-arg399gln hogg1-ser326cys endometrial carcinoma polymorphism meta-analysis genetic susceptibility |
| url | https://doi.org/10.1515/med-2024-0913 |
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