Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog
Choroid plexus tumors are commonly described as intraventricular mass lesions and account for 7–10% of intracranial, primary tumors in dogs. A 3-year-old Shetland sheepdog was presented with a history of slowly progressive lethargy, vision impairment and cognitive deficits. On magnetic resonance ima...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/1/24 |
| _version_ | 1827621423224455168 |
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| author | Nina Schneider Andreas Blutke Kaspar Matiasek Birgit Parzefall |
| author_facet | Nina Schneider Andreas Blutke Kaspar Matiasek Birgit Parzefall |
| author_sort | Nina Schneider |
| collection | DOAJ |
| description | Choroid plexus tumors are commonly described as intraventricular mass lesions and account for 7–10% of intracranial, primary tumors in dogs. A 3-year-old Shetland sheepdog was presented with a history of slowly progressive lethargy, vision impairment and cognitive deficits. On magnetic resonance imaging, a subdural fluid accumulation (SFA) overlying and compressing the left parietotemporal lobe as well as multifocal changes consisting of cyst-like lesions, supposed intra-axial brain lesions and mild, multifocal meningeal thickening and generalized contrast enhancement were identified. Cerebrospinal fluid (CSF) analysis showed a mononuclear pleocytosis with negative results for infectious agents. The dog was treated with prednisolone followed by burr hole craniotomy with puncture of the SFA, which macroscopically appeared to be CSF-like fluid. After initial improvement, the dog deteriorated despite continuation of prednisolone and cytarabine therapy and was euthanized four weeks after surgery. Histopathology was consistent with a disseminated, neuroinvasive choroid plexus carcinoma (CPC) that involved the entire neuroaxis including the meninges of the brain and spinal cord. Immunohistochemical examination showed a strong Kir7.1 and a heterogenous cytokeratin-immunoreactivity in neoplastic cells. In conclusion, a CPC should be considered as a possible cause of a SFA even in the absence of an intraventricular mass lesion. |
| first_indexed | 2024-03-09T11:03:29Z |
| format | Article |
| id | doaj.art-a5da178b267a439981bec5e6f881136a |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T11:03:29Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-a5da178b267a439981bec5e6f881136a2023-12-01T01:05:38ZengMDPI AGVeterinary Sciences2306-73812022-12-011012410.3390/vetsci10010024Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a DogNina Schneider0Andreas Blutke1Kaspar Matiasek2Birgit Parzefall3Small Animal Clinic Oberhaching, Bajuwarenring 10, 82041 Oberhaching, GermanyInstitute of Veterinary Pathology, Center for Clinical Veterinary Medicine, Ludwig-Maximilians Universität München, Veterinärstr. 13, 80539 Munich, GermanyInstitute of Veterinary Pathology, Center for Clinical Veterinary Medicine, Ludwig-Maximilians Universität München, Veterinärstr. 13, 80539 Munich, GermanySmall Animal Clinic Oberhaching, Bajuwarenring 10, 82041 Oberhaching, GermanyChoroid plexus tumors are commonly described as intraventricular mass lesions and account for 7–10% of intracranial, primary tumors in dogs. A 3-year-old Shetland sheepdog was presented with a history of slowly progressive lethargy, vision impairment and cognitive deficits. On magnetic resonance imaging, a subdural fluid accumulation (SFA) overlying and compressing the left parietotemporal lobe as well as multifocal changes consisting of cyst-like lesions, supposed intra-axial brain lesions and mild, multifocal meningeal thickening and generalized contrast enhancement were identified. Cerebrospinal fluid (CSF) analysis showed a mononuclear pleocytosis with negative results for infectious agents. The dog was treated with prednisolone followed by burr hole craniotomy with puncture of the SFA, which macroscopically appeared to be CSF-like fluid. After initial improvement, the dog deteriorated despite continuation of prednisolone and cytarabine therapy and was euthanized four weeks after surgery. Histopathology was consistent with a disseminated, neuroinvasive choroid plexus carcinoma (CPC) that involved the entire neuroaxis including the meninges of the brain and spinal cord. Immunohistochemical examination showed a strong Kir7.1 and a heterogenous cytokeratin-immunoreactivity in neoplastic cells. In conclusion, a CPC should be considered as a possible cause of a SFA even in the absence of an intraventricular mass lesion.https://www.mdpi.com/2306-7381/10/1/24choroid plexus tumorcystsdiffusemeningealmetastasis |
| spellingShingle | Nina Schneider Andreas Blutke Kaspar Matiasek Birgit Parzefall Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog Veterinary Sciences choroid plexus tumor cysts diffuse meningeal metastasis |
| title | Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog |
| title_full | Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog |
| title_fullStr | Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog |
| title_full_unstemmed | Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog |
| title_short | Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog |
| title_sort | intracranial subdural fluid accumulation associated with a choroid plexus carcinoma in a dog |
| topic | choroid plexus tumor cysts diffuse meningeal metastasis |
| url | https://www.mdpi.com/2306-7381/10/1/24 |
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