Microcephaly, an etiopathogenic vision
Microcephaly is defined by an occipital-frontal head circumference (OFD) 2 standard deviations (SD) smaller than the average expected for age, gender and population. Its incidence has been reported between 1.3 and 150 cases per 100,000 births. Currently, new clinical characteristics, causes and path...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957221000887 |
| _version_ | 1819147428753833984 |
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| author | Luis Eduardo Becerra-Solano Leovigildo Mateos-Sánchez Eunice López-Muñoz |
| author_facet | Luis Eduardo Becerra-Solano Leovigildo Mateos-Sánchez Eunice López-Muñoz |
| author_sort | Luis Eduardo Becerra-Solano |
| collection | DOAJ |
| description | Microcephaly is defined by an occipital-frontal head circumference (OFD) 2 standard deviations (SD) smaller than the average expected for age, gender and population. Its incidence has been reported between 1.3 and 150 cases per 100,000 births. Currently, new clinical characteristics, causes and pathophysiological mechanisms related to microcephaly continue to be identified. Its etiology is varied and heterogeneous, with genetic and non-genetic factors that produce alterations in differentiation, proliferation, migration, repair of damage to deoxyribonucleic acid and neuronal apoptosis. It requires a multidisciplinary diagnostic approach that includes a medical history, detailed prenatal and postnatal clinical evaluation, cerebral magnetic resonance imaging, neuropsychological evaluation, and in some cases complementary tests such as metabolic screening, tests to rule out infectious processes and genetic testing. There is no specific treatment or intervention to increase cerebral growth; however, timely intervention strategies and programs can be established to improve motor and neurocognitive development, as well as to provide genetic counseling. The objective of this work is to review the available information and reinforce the proposal to carry out an etiopathogenic approach for microcephaly diagnosis and management. |
| first_indexed | 2024-12-22T13:29:40Z |
| format | Article |
| id | doaj.art-a5dbff2ceb5f4cc094c370e75e463bdf |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-22T13:29:40Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-a5dbff2ceb5f4cc094c370e75e463bdf2022-12-21T18:24:13ZengElsevierPediatrics and Neonatology1875-95722021-07-01624354360Microcephaly, an etiopathogenic visionLuis Eduardo Becerra-Solano0Leovigildo Mateos-Sánchez1Eunice López-Muñoz2Medical Research Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad, Hospital de Gineco Obstetricia No. 4, “Luis Castelazo Ayala”, Instituto Mexicano del Seguro Social, Río Magdalena 289, Level 6, Laboratory K, Colonia Tizapan San Ángel, Alcaldía Álvaro Obregón, C.P. 01090, Mexico City, MexicoNeonatal Intensive Care Unit, Unidad Médica de Alta Especialidad, Hospital de Gineco Obstetricia No. 4, “Luis Castelazo Ayala”, Instituto Mexicano del Seguro Social, Río Magdalena 289, Mezzanine, Colonia Tizapan San Ángel, Alcaldía Álvaro Obregón, C.P. 01090, Mexico City, MexicoMedical Research Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad, Hospital de Gineco Obstetricia No. 4, “Luis Castelazo Ayala”, Instituto Mexicano del Seguro Social, Río Magdalena 289, Level 6, Laboratory K, Colonia Tizapan San Ángel, Alcaldía Álvaro Obregón, C.P. 01090, Mexico City, Mexico; Corresponding author.Microcephaly is defined by an occipital-frontal head circumference (OFD) 2 standard deviations (SD) smaller than the average expected for age, gender and population. Its incidence has been reported between 1.3 and 150 cases per 100,000 births. Currently, new clinical characteristics, causes and pathophysiological mechanisms related to microcephaly continue to be identified. Its etiology is varied and heterogeneous, with genetic and non-genetic factors that produce alterations in differentiation, proliferation, migration, repair of damage to deoxyribonucleic acid and neuronal apoptosis. It requires a multidisciplinary diagnostic approach that includes a medical history, detailed prenatal and postnatal clinical evaluation, cerebral magnetic resonance imaging, neuropsychological evaluation, and in some cases complementary tests such as metabolic screening, tests to rule out infectious processes and genetic testing. There is no specific treatment or intervention to increase cerebral growth; however, timely intervention strategies and programs can be established to improve motor and neurocognitive development, as well as to provide genetic counseling. The objective of this work is to review the available information and reinforce the proposal to carry out an etiopathogenic approach for microcephaly diagnosis and management.http://www.sciencedirect.com/science/article/pii/S1875957221000887acquired microcephalycongenital microcephalyisolated microcephalymicrocephaly primary hereditary (MCPH)Syndromicmicrocephaly |
| spellingShingle | Luis Eduardo Becerra-Solano Leovigildo Mateos-Sánchez Eunice López-Muñoz Microcephaly, an etiopathogenic vision Pediatrics and Neonatology acquired microcephaly congenital microcephaly isolated microcephaly microcephaly primary hereditary (MCPH) Syndromicmicrocephaly |
| title | Microcephaly, an etiopathogenic vision |
| title_full | Microcephaly, an etiopathogenic vision |
| title_fullStr | Microcephaly, an etiopathogenic vision |
| title_full_unstemmed | Microcephaly, an etiopathogenic vision |
| title_short | Microcephaly, an etiopathogenic vision |
| title_sort | microcephaly an etiopathogenic vision |
| topic | acquired microcephaly congenital microcephaly isolated microcephaly microcephaly primary hereditary (MCPH) Syndromicmicrocephaly |
| url | http://www.sciencedirect.com/science/article/pii/S1875957221000887 |
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