Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study
Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Intere...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2013-03-01
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| Series: | Case Reports in Dermatology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/350184 |
| _version_ | 1819075305281683456 |
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| author | Taku Fujimura Sadanori Furudate Masaya Ishibashi Yumi Kambayashi Gen-ichi Tojo Chihiro Wakusawa Hiroshi Mayama Setsuya Aiba |
| author_facet | Taku Fujimura Sadanori Furudate Masaya Ishibashi Yumi Kambayashi Gen-ichi Tojo Chihiro Wakusawa Hiroshi Mayama Setsuya Aiba |
| author_sort | Taku Fujimura |
| collection | DOAJ |
| description | Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163+ proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC. |
| first_indexed | 2024-12-21T18:23:18Z |
| format | Article |
| id | doaj.art-a5dc52dd6fc9438ea97b9dfe0422168c |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-12-21T18:23:18Z |
| publishDate | 2013-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-a5dc52dd6fc9438ea97b9dfe0422168c2022-12-21T18:54:29ZengKarger PublishersCase Reports in Dermatology1662-65672013-03-0151798310.1159/000350184350184Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical StudyTaku FujimuraSadanori FurudateMasaya IshibashiYumi KambayashiGen-ichi TojoChihiro WakusawaHiroshi MayamaSetsuya AibaPlasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163+ proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.http://www.karger.com/Article/FullText/350184Proinflammatory cytokineCD163+ macrophagesIL-17Plasmacytosis circumorificialisTacrolimus |
| spellingShingle | Taku Fujimura Sadanori Furudate Masaya Ishibashi Yumi Kambayashi Gen-ichi Tojo Chihiro Wakusawa Hiroshi Mayama Setsuya Aiba Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study Case Reports in Dermatology Proinflammatory cytokine CD163+ macrophages IL-17 Plasmacytosis circumorificialis Tacrolimus |
| title | Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study |
| title_full | Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study |
| title_fullStr | Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study |
| title_full_unstemmed | Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study |
| title_short | Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study |
| title_sort | successful treatment of plasmacytosis circumorificialis with topical tacrolimus two case reports and an immunohistochemical study |
| topic | Proinflammatory cytokine CD163+ macrophages IL-17 Plasmacytosis circumorificialis Tacrolimus |
| url | http://www.karger.com/Article/FullText/350184 |
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