Role of Single Procalcitonin Test on Admission as a Biomarker for Predicting the Severity of Clostridium difficile Infection
Objective: To evaluate whether serum Procalcitonin (PCT) at the early stage of infection can serve as a potential biomarker for determining Clostridium difficile infection (CDI) severity.Methods: Fifty-four patients diagnosed with CDI were enrolled in the study. Serum samples were obtained within a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2017.02532/full |
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| author | Zohar Hamo Zohar Hamo Maya Azrad Orna Nitzan Orna Nitzan Asaf Sagie Linda Tkhawkho Dana Binyamin Dana Binyamin Avi Peretz Avi Peretz |
| author_facet | Zohar Hamo Zohar Hamo Maya Azrad Orna Nitzan Orna Nitzan Asaf Sagie Linda Tkhawkho Dana Binyamin Dana Binyamin Avi Peretz Avi Peretz |
| author_sort | Zohar Hamo |
| collection | DOAJ |
| description | Objective: To evaluate whether serum Procalcitonin (PCT) at the early stage of infection can serve as a potential biomarker for determining Clostridium difficile infection (CDI) severity.Methods: Fifty-four patients diagnosed with CDI were enrolled in the study. Serum samples were obtained within a median time of 24–48 h of the lab result for presence of C. difficile. PCT levels were measured by chemiluminescence immunoassay. Demographic, clinical, and prognostic data concerning the patients were retrospectively collected from medical records. The illness severity score was determined according to “Score indices for C. difficile infection severity.”Results: We found that serum PCT levels were significantly higher in patients with moderate disease, compared to patients with mild disease (p = 0.0032). Additionally, PCT was correlated with mortality (p = 0.0002), white blood cell count (p = 0.019), and community-acquired disease (p = 0.0345).Conclusion: Early measurement of PCT may serve as a biomarker for early prediction of CDI severity, which is of great importance due to the high risk of complications and death. |
| first_indexed | 2024-12-11T09:17:25Z |
| format | Article |
| id | doaj.art-a5dc9f39d1c14ac4bee66d8580d52eaa |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-11T09:17:25Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-a5dc9f39d1c14ac4bee66d8580d52eaa2022-12-22T01:13:20ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-12-01810.3389/fmicb.2017.02532319729Role of Single Procalcitonin Test on Admission as a Biomarker for Predicting the Severity of Clostridium difficile InfectionZohar Hamo0Zohar Hamo1Maya Azrad2Orna Nitzan3Orna Nitzan4Asaf Sagie5Linda Tkhawkho6Dana Binyamin7Dana Binyamin8Avi Peretz9Avi Peretz10Clinical Microbiology Laboratory, The Baruch Padeh Medical Center, Poriya, Tiberias, IsraelThe Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, IsraelClinical Microbiology Laboratory, The Baruch Padeh Medical Center, Poriya, Tiberias, IsraelClinical Microbiology Laboratory, The Baruch Padeh Medical Center, Poriya, Tiberias, IsraelInfectious Diseases Unit, The Baruch Padeh Medical Center, Poriya, Tiberias, IsraelThe Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, IsraelClinical Microbiology Laboratory, The Baruch Padeh Medical Center, Poriya, Tiberias, IsraelClinical Microbiology Laboratory, The Baruch Padeh Medical Center, Poriya, Tiberias, IsraelThe Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, IsraelClinical Microbiology Laboratory, The Baruch Padeh Medical Center, Poriya, Tiberias, IsraelThe Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, IsraelObjective: To evaluate whether serum Procalcitonin (PCT) at the early stage of infection can serve as a potential biomarker for determining Clostridium difficile infection (CDI) severity.Methods: Fifty-four patients diagnosed with CDI were enrolled in the study. Serum samples were obtained within a median time of 24–48 h of the lab result for presence of C. difficile. PCT levels were measured by chemiluminescence immunoassay. Demographic, clinical, and prognostic data concerning the patients were retrospectively collected from medical records. The illness severity score was determined according to “Score indices for C. difficile infection severity.”Results: We found that serum PCT levels were significantly higher in patients with moderate disease, compared to patients with mild disease (p = 0.0032). Additionally, PCT was correlated with mortality (p = 0.0002), white blood cell count (p = 0.019), and community-acquired disease (p = 0.0345).Conclusion: Early measurement of PCT may serve as a biomarker for early prediction of CDI severity, which is of great importance due to the high risk of complications and death.http://journal.frontiersin.org/article/10.3389/fmicb.2017.02532/fullClostridium difficileprocalcitoninbiomarkerscore indicesantibiotic-associated diarrhea |
| spellingShingle | Zohar Hamo Zohar Hamo Maya Azrad Orna Nitzan Orna Nitzan Asaf Sagie Linda Tkhawkho Dana Binyamin Dana Binyamin Avi Peretz Avi Peretz Role of Single Procalcitonin Test on Admission as a Biomarker for Predicting the Severity of Clostridium difficile Infection Frontiers in Microbiology Clostridium difficile procalcitonin biomarker score indices antibiotic-associated diarrhea |
| title | Role of Single Procalcitonin Test on Admission as a Biomarker for Predicting the Severity of Clostridium difficile Infection |
| title_full | Role of Single Procalcitonin Test on Admission as a Biomarker for Predicting the Severity of Clostridium difficile Infection |
| title_fullStr | Role of Single Procalcitonin Test on Admission as a Biomarker for Predicting the Severity of Clostridium difficile Infection |
| title_full_unstemmed | Role of Single Procalcitonin Test on Admission as a Biomarker for Predicting the Severity of Clostridium difficile Infection |
| title_short | Role of Single Procalcitonin Test on Admission as a Biomarker for Predicting the Severity of Clostridium difficile Infection |
| title_sort | role of single procalcitonin test on admission as a biomarker for predicting the severity of clostridium difficile infection |
| topic | Clostridium difficile procalcitonin biomarker score indices antibiotic-associated diarrhea |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2017.02532/full |
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