Flavonol and A-type procyanidin-rich extracts of Prunus spinosa L. flower exhibit anticoagulant activity through direct thrombin inhibition, but do not affect platelet aggregation in vitro

Flavonol and A-type procyanidin-rich extracts of Prunus spinosa L. flower exhibit anticoagulant activity through direct thrombin inhibition, but do not affect platelet aggregation in vitro

Background: Blackthorn flower (Prunus spinosa L.) is a traditional herbal remedy recommended for treating cardiovascular diseases (CVDs).Aim: This in vitro study investigates the effects of flavonol and A-type procyanidin-rich blackthorn flower extracts on the hemostatic system, including the blood...

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Bibliographic Details
Main Authors: Anna Marchelak, Joanna Kolodziejczyk-Czepas, Michał B. Ponczek, Oleksandra Liudvytska, Magdalena Markowicz-Piasecka, Beata Bielska, Katarzyna Miłowska, Monika A. Olszewska
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
Prunus spinosa
blackthorn flowers
polyphenols
hemostasis
thrombin
anticoagulant
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1307373/full

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