Identification of the effect of lycopene on the inhibition of yellow fever-causing flavivirus by studying microarray gene expression data
Introduction: Yellow fever virus causes systemic disease of the liver, kidneys, myocardium and hemorrhage, which are high incidence and mortality. Lycopene is one of the effective antioxidants used to prevent the growth of cancerous tumors. DNAJC14 protein is a variant of heat shock protein (chapero...
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| Format: | Article |
| Language: | English |
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Zabansaraye Parsian Novin Mehr Institute
2022-06-01
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| Series: | Journal of Current Oncology and Medical Sciences |
| Subjects: | |
| Online Access: | http://submission.journalofcoms.com/index.php/JCOMS/article/view/40 |
| _version_ | 1797861910790537216 |
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| author | Gholamreza Dadashi Oranj |
| author_facet | Gholamreza Dadashi Oranj |
| author_sort | Gholamreza Dadashi Oranj |
| collection | DOAJ |
| description | Introduction: Yellow fever virus causes systemic disease of the liver, kidneys, myocardium and hemorrhage, which are high incidence and mortality. Lycopene is one of the effective antioxidants used to prevent the growth of cancerous tumors. DNAJC14 protein is a variant of heat shock protein (chaperone) Hsp40. Hsp40 chaperone protein (DNAJC14) that when overexpressed was able to mediate protection from yellow fever virus (YFV)-induced cell death. In this study, to find a new treatment for yellow fever, the effect of lycopene on the expression of DNAJC14 gene involved in yellow fever was investigated.
Materials and methods: In this project, using bioinformatics software, such as Matlab and Cytoscape, the effect of lycopene on the expression of DNAJC14 gene, as well as the relationship of this gene with different genes have been investigated. Big gene expression data in the NCBI database were used for this study.
Results: Analysis of microarray data showed that the expression level of DNAJC14 gene was increased under the influence of lycopene.
Conclusion: The lycopene combination can be used as a preventative and even treatment for yellow fever viral disease due to the effect DNAJC14 gene expression. |
| first_indexed | 2024-04-09T22:10:53Z |
| format | Article |
| id | doaj.art-a5e162530c9c4da596c35e4634f1cda6 |
| institution | Directory Open Access Journal |
| issn | 2783-3127 |
| language | English |
| last_indexed | 2024-04-09T22:10:53Z |
| publishDate | 2022-06-01 |
| publisher | Zabansaraye Parsian Novin Mehr Institute |
| record_format | Article |
| series | Journal of Current Oncology and Medical Sciences |
| spelling | doaj.art-a5e162530c9c4da596c35e4634f1cda62023-03-23T11:22:12ZengZabansaraye Parsian Novin Mehr InstituteJournal of Current Oncology and Medical Sciences2783-31272022-06-0122196201Identification of the effect of lycopene on the inhibition of yellow fever-causing flavivirus by studying microarray gene expression dataGholamreza Dadashi Oranj0Cellular and Molecular Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, IranIntroduction: Yellow fever virus causes systemic disease of the liver, kidneys, myocardium and hemorrhage, which are high incidence and mortality. Lycopene is one of the effective antioxidants used to prevent the growth of cancerous tumors. DNAJC14 protein is a variant of heat shock protein (chaperone) Hsp40. Hsp40 chaperone protein (DNAJC14) that when overexpressed was able to mediate protection from yellow fever virus (YFV)-induced cell death. In this study, to find a new treatment for yellow fever, the effect of lycopene on the expression of DNAJC14 gene involved in yellow fever was investigated. Materials and methods: In this project, using bioinformatics software, such as Matlab and Cytoscape, the effect of lycopene on the expression of DNAJC14 gene, as well as the relationship of this gene with different genes have been investigated. Big gene expression data in the NCBI database were used for this study. Results: Analysis of microarray data showed that the expression level of DNAJC14 gene was increased under the influence of lycopene. Conclusion: The lycopene combination can be used as a preventative and even treatment for yellow fever viral disease due to the effect DNAJC14 gene expression.http://submission.journalofcoms.com/index.php/JCOMS/article/view/40lycopeneyellow feverbioinformaticsco- expressionmicroarraycytoscape |
| spellingShingle | Gholamreza Dadashi Oranj Identification of the effect of lycopene on the inhibition of yellow fever-causing flavivirus by studying microarray gene expression data Journal of Current Oncology and Medical Sciences lycopene yellow fever bioinformatics co- expression microarray cytoscape |
| title | Identification of the effect of lycopene on the inhibition of yellow fever-causing flavivirus by studying microarray gene expression data |
| title_full | Identification of the effect of lycopene on the inhibition of yellow fever-causing flavivirus by studying microarray gene expression data |
| title_fullStr | Identification of the effect of lycopene on the inhibition of yellow fever-causing flavivirus by studying microarray gene expression data |
| title_full_unstemmed | Identification of the effect of lycopene on the inhibition of yellow fever-causing flavivirus by studying microarray gene expression data |
| title_short | Identification of the effect of lycopene on the inhibition of yellow fever-causing flavivirus by studying microarray gene expression data |
| title_sort | identification of the effect of lycopene on the inhibition of yellow fever causing flavivirus by studying microarray gene expression data |
| topic | lycopene yellow fever bioinformatics co- expression microarray cytoscape |
| url | http://submission.journalofcoms.com/index.php/JCOMS/article/view/40 |
| work_keys_str_mv | AT gholamrezadadashioranj identificationoftheeffectoflycopeneontheinhibitionofyellowfevercausingflavivirusbystudyingmicroarraygeneexpressiondata |