Maternal serum autotaxin levels in early- and late-onset preeclampsia
Purpose: We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital. Methods: A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided in...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-10-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2017.1388389 |
| _version_ | 1797681598316937216 |
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| author | Hakan Erenel Nevin Yilmaz Tayfur Cift Berk Bulut Isik Sozen Berna Aslan Cetin Altay Gezer Hakan Ekmekci Baris Kaya Abdullah Tuten |
| author_facet | Hakan Erenel Nevin Yilmaz Tayfur Cift Berk Bulut Isik Sozen Berna Aslan Cetin Altay Gezer Hakan Ekmekci Baris Kaya Abdullah Tuten |
| author_sort | Hakan Erenel |
| collection | DOAJ |
| description | Purpose: We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital. Methods: A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia (n = 31) and late-onset preeclampsia (n = 24). Demographic and clinical data were compared between early-onset and late-onset preeclamptic patients. The control group was composed of 32 healthy pregnant patients. Results: The mean autotaxin levels were 1.16 ± 0.97 and 0.7 ± 0.35 ng/ml in the early- and late-onset preeclampsia groups, respectively. Autotaxin levels were significantly higher in early-onset preeclampsia group compared with late-onset preeclampsia group. Autotaxin levels were found to be significantly higher in preeclamptic patients compared with control group. Serum autotaxin levels showed a significant positive correlation with maternal systolic, diastolic blood pressures and uric acid levels. Conclusion: Autotaxin might be a promising marker for detecting early-onset preeclampsia. However, further studies are necessary to confirm this hypothesis. |
| first_indexed | 2024-03-11T23:47:16Z |
| format | Article |
| id | doaj.art-a5e31834d397423ab1a1134daaf5e277 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:47:16Z |
| publishDate | 2017-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-a5e31834d397423ab1a1134daaf5e2772023-09-19T09:24:42ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652017-10-0136431031410.1080/10641955.2017.13883891388389Maternal serum autotaxin levels in early- and late-onset preeclampsiaHakan Erenel0Nevin Yilmaz1Tayfur Cift2Berk Bulut3Isik Sozen4Berna Aslan Cetin5Altay Gezer6Hakan Ekmekci7Baris Kaya8Abdullah Tuten9Istanbul University Cerrahpasa Medical FacultyIstanbul University Cerrahpasa Medical FacultyBursa Yüksek ihtisas Education and Research HospitalLiv HospitalIstanbul University Cerrahpasa Medical FacultyKanuni Sultan Suleyman Education and Research HospitalIstanbul University Cerrahpasa Medical FacultyIstanbul University Cerrahpasa Medical FacultyNear East UniversityIstanbul University Cerrahpasa Medical FacultyPurpose: We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital. Methods: A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia (n = 31) and late-onset preeclampsia (n = 24). Demographic and clinical data were compared between early-onset and late-onset preeclamptic patients. The control group was composed of 32 healthy pregnant patients. Results: The mean autotaxin levels were 1.16 ± 0.97 and 0.7 ± 0.35 ng/ml in the early- and late-onset preeclampsia groups, respectively. Autotaxin levels were significantly higher in early-onset preeclampsia group compared with late-onset preeclampsia group. Autotaxin levels were found to be significantly higher in preeclamptic patients compared with control group. Serum autotaxin levels showed a significant positive correlation with maternal systolic, diastolic blood pressures and uric acid levels. Conclusion: Autotaxin might be a promising marker for detecting early-onset preeclampsia. However, further studies are necessary to confirm this hypothesis.http://dx.doi.org/10.1080/10641955.2017.1388389preeclampsiaautotaxinpregnancyearly-onset preeclampsialate-onset preeclampsia |
| spellingShingle | Hakan Erenel Nevin Yilmaz Tayfur Cift Berk Bulut Isik Sozen Berna Aslan Cetin Altay Gezer Hakan Ekmekci Baris Kaya Abdullah Tuten Maternal serum autotaxin levels in early- and late-onset preeclampsia Hypertension in Pregnancy preeclampsia autotaxin pregnancy early-onset preeclampsia late-onset preeclampsia |
| title | Maternal serum autotaxin levels in early- and late-onset preeclampsia |
| title_full | Maternal serum autotaxin levels in early- and late-onset preeclampsia |
| title_fullStr | Maternal serum autotaxin levels in early- and late-onset preeclampsia |
| title_full_unstemmed | Maternal serum autotaxin levels in early- and late-onset preeclampsia |
| title_short | Maternal serum autotaxin levels in early- and late-onset preeclampsia |
| title_sort | maternal serum autotaxin levels in early and late onset preeclampsia |
| topic | preeclampsia autotaxin pregnancy early-onset preeclampsia late-onset preeclampsia |
| url | http://dx.doi.org/10.1080/10641955.2017.1388389 |
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