The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder
Selenium and selenoproteins play a role in many biological functions, particularly in brain development and function. This review outlines the role of each class of selenoprotein in human brain function. Most selenoproteins play a large antioxidant role within the brain. Autism spectrum disorder (AS...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1130922/full |
| _version_ | 1811157703813234688 |
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| author | Supriya Behl Supriya Behl Sunil Mehta Mukesh K. Pandey |
| author_facet | Supriya Behl Supriya Behl Sunil Mehta Mukesh K. Pandey |
| author_sort | Supriya Behl |
| collection | DOAJ |
| description | Selenium and selenoproteins play a role in many biological functions, particularly in brain development and function. This review outlines the role of each class of selenoprotein in human brain function. Most selenoproteins play a large antioxidant role within the brain. Autism spectrum disorder (ASD) has been shown to correlate with increased oxidative stress, and the presumption of selenoproteins as key players in ASD etiology are discussed. Further, current literature surrounding selenium in ASD and selenium supplementation studies are reviewed. Finally, perspectives are given for future directions of selenoprotein research in ASD. |
| first_indexed | 2024-04-10T05:11:48Z |
| format | Article |
| id | doaj.art-a5e3394b77c040b591d8775717194e66 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-10T05:11:48Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-a5e3394b77c040b591d8775717194e662023-03-09T07:22:50ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-03-011610.3389/fnmol.2023.11309221130922The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorderSupriya Behl0Supriya Behl1Sunil Mehta2Mukesh K. Pandey3Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, United StatesCenter for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, United StatesDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, United StatesDepartment of Radiology, Mayo Clinic, Rochester, MN, United StatesSelenium and selenoproteins play a role in many biological functions, particularly in brain development and function. This review outlines the role of each class of selenoprotein in human brain function. Most selenoproteins play a large antioxidant role within the brain. Autism spectrum disorder (ASD) has been shown to correlate with increased oxidative stress, and the presumption of selenoproteins as key players in ASD etiology are discussed. Further, current literature surrounding selenium in ASD and selenium supplementation studies are reviewed. Finally, perspectives are given for future directions of selenoprotein research in ASD.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1130922/fullmetal micronutrientsseleniumautism spectrum disorderbrain functionbrain development |
| spellingShingle | Supriya Behl Supriya Behl Sunil Mehta Mukesh K. Pandey The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder Frontiers in Molecular Neuroscience metal micronutrients selenium autism spectrum disorder brain function brain development |
| title | The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder |
| title_full | The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder |
| title_fullStr | The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder |
| title_full_unstemmed | The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder |
| title_short | The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder |
| title_sort | role of selenoproteins in neurodevelopment and neurological function implications in autism spectrum disorder |
| topic | metal micronutrients selenium autism spectrum disorder brain function brain development |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1130922/full |
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