Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring
Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1287255/full |
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| author | Szilvia Bokor Szilvia Bokor Ildikó Csölle Ildikó Csölle Ildikó Csölle Regina Felső Regina Felső Réka A. Vass Réka A. Vass Réka A. Vass Simone Funke Simone Funke Tibor Ertl Tibor Ertl Dénes Molnár Dénes Molnár |
| author_facet | Szilvia Bokor Szilvia Bokor Ildikó Csölle Ildikó Csölle Ildikó Csölle Regina Felső Regina Felső Réka A. Vass Réka A. Vass Réka A. Vass Simone Funke Simone Funke Tibor Ertl Tibor Ertl Dénes Molnár Dénes Molnár |
| author_sort | Szilvia Bokor |
| collection | DOAJ |
| description | Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring’s phenotype (obesity and related metabolic changes). With our literature search, we found evidence for the association between alterations in DNA methylation pattern of different genes caused by maternal under- or overnutrition of several nutrients (protein, fructose, fat, vitamin D, methyl-group donor nutrients) during 3 critical periods of programming (preconception, pregnancy, lactation) and the development of obesity or related metabolic changes (glucose, insulin, lipid, leptin, adiponectin levels, blood pressure, non-alcoholic fatty liver disease) in offspring. The review highlights that maternal consumption of several nutrients could individually affect the development of offspring’s obesity and related metabolic changes via alterations in DNA methylation. |
| first_indexed | 2024-03-07T23:10:13Z |
| format | Article |
| id | doaj.art-a5e3c7e332a748a18ae8f9102cfa19c4 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T23:10:13Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a5e3c7e332a748a18ae8f9102cfa19c42024-02-21T14:24:34ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.12872551287255Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspringSzilvia Bokor0Szilvia Bokor1Ildikó Csölle2Ildikó Csölle3Ildikó Csölle4Regina Felső5Regina Felső6Réka A. Vass7Réka A. Vass8Réka A. Vass9Simone Funke10Simone Funke11Tibor Ertl12Tibor Ertl13Dénes Molnár14Dénes Molnár15Department of Paediatrics, Medical School, University of Pécs, Pécs, HungaryNational Laboratory on Human Reproduction, University of Pécs, Pécs, HungaryDepartment of Paediatrics, Medical School, University of Pécs, Pécs, HungaryNational Laboratory on Human Reproduction, University of Pécs, Pécs, HungaryDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, HungaryDepartment of Paediatrics, Medical School, University of Pécs, Pécs, HungaryNational Laboratory on Human Reproduction, University of Pécs, Pécs, HungaryNational Laboratory on Human Reproduction, University of Pécs, Pécs, HungaryDepartment of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, HungaryObstetrics and Gynecology, Magyar Imre Hospital Ajka, Ajka, HungaryNational Laboratory on Human Reproduction, University of Pécs, Pécs, HungaryDepartment of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, HungaryNational Laboratory on Human Reproduction, University of Pécs, Pécs, HungaryDepartment of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, HungaryDepartment of Paediatrics, Medical School, University of Pécs, Pécs, HungaryNational Laboratory on Human Reproduction, University of Pécs, Pécs, HungaryGrowing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring’s phenotype (obesity and related metabolic changes). With our literature search, we found evidence for the association between alterations in DNA methylation pattern of different genes caused by maternal under- or overnutrition of several nutrients (protein, fructose, fat, vitamin D, methyl-group donor nutrients) during 3 critical periods of programming (preconception, pregnancy, lactation) and the development of obesity or related metabolic changes (glucose, insulin, lipid, leptin, adiponectin levels, blood pressure, non-alcoholic fatty liver disease) in offspring. The review highlights that maternal consumption of several nutrients could individually affect the development of offspring’s obesity and related metabolic changes via alterations in DNA methylation.https://www.frontiersin.org/articles/10.3389/fendo.2024.1287255/fullobesitymetabolic syndromematernalnutritionepigeneticDNA methylation |
| spellingShingle | Szilvia Bokor Szilvia Bokor Ildikó Csölle Ildikó Csölle Ildikó Csölle Regina Felső Regina Felső Réka A. Vass Réka A. Vass Réka A. Vass Simone Funke Simone Funke Tibor Ertl Tibor Ertl Dénes Molnár Dénes Molnár Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring Frontiers in Endocrinology obesity metabolic syndrome maternal nutrition epigenetic DNA methylation |
| title | Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring |
| title_full | Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring |
| title_fullStr | Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring |
| title_full_unstemmed | Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring |
| title_short | Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring |
| title_sort | dietary nutrients during gestation cause obesity and related metabolic changes by altering dna methylation in the offspring |
| topic | obesity metabolic syndrome maternal nutrition epigenetic DNA methylation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1287255/full |
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