The maturation of exploratory behavior in adolescent Mus spicilegus on two photoperiods
Dispersal from the natal site or familial group is a core milestone of adolescent development in many species. A wild species of mouse, Mus spicilegus, presents an exciting model in which to study adolescent development and dispersal because it shows different life history trajectory depending on se...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.988033/full |
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| author | Noah G. Cryns Wan Chen Lin Niloofar Motahari Oliver J. Krentzman Weihang Chen George Prounis Linda Wilbrecht Linda Wilbrecht |
| author_facet | Noah G. Cryns Wan Chen Lin Niloofar Motahari Oliver J. Krentzman Weihang Chen George Prounis Linda Wilbrecht Linda Wilbrecht |
| author_sort | Noah G. Cryns |
| collection | DOAJ |
| description | Dispersal from the natal site or familial group is a core milestone of adolescent development in many species. A wild species of mouse, Mus spicilegus, presents an exciting model in which to study adolescent development and dispersal because it shows different life history trajectory depending on season of birth. M. spicilegus born in spring and summer on long days (LD) disperse in the first 3 months of life, while M. spicilegus born on shorter autumnal days (SD) delay dispersal through the wintertime. We were interested in using these mice in a laboratory context to compare age-matched mice with differential motivation to disperse. To first test if we could find a proxy for dispersal related behavior in the laboratory environment, we measured open field and novel object investigation across development in M. spicilegus raised on a LD 12 h:12 h light:dark cycle. We found that between the first and second month of life, distance traveled and time in center of the open field increased significantly with age in M. spicilegus. Robust novel object investigation was observed in all age groups and decreased between the 2nd and 3rd month of life in LD males. Compared to male C57BL/6 mice, male M. spicilegus traveled significantly longer distances in the open field but spent less time in the center of the field. However, when a novel object was placed in the center of the open field, Male M. spicilegus, were significantly more willing to contact and mount it. To test if autumnal photoperiod affects exploratory behavior in M. spicilegus in a laboratory environment, we reared a cohort of M. spicilegus on a SD 10 h:14 h photoperiod and tested their exploratory behavior at P60-70. At this timepoint, we found SD rearing had no effect on open field metrics, but led to reduced novel object investigation. We also observed that in P60-70 males, SD reared M. spicilegus weighed less than LD reared M. spicilegus. These observations establish that SD photoperiod can delay weight gain and blunt some, but not all forms of exploratory behavior in adolescent M. spicilegus. |
| first_indexed | 2024-04-11T23:21:05Z |
| format | Article |
| id | doaj.art-a5e4ca016fcb4e59989587f2a2b5d5ca |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-11T23:21:05Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-a5e4ca016fcb4e59989587f2a2b5d5ca2022-12-22T03:57:27ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532022-11-011610.3389/fnbeh.2022.988033988033The maturation of exploratory behavior in adolescent Mus spicilegus on two photoperiodsNoah G. Cryns0Wan Chen Lin1Niloofar Motahari2Oliver J. Krentzman3Weihang Chen4George Prounis5Linda Wilbrecht6Linda Wilbrecht7Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA, United StatesHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United StatesDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA, United StatesHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United StatesDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA, United StatesHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United StatesHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United StatesDepartment of Psychology, University of California, Berkeley, Berkeley, CA, United StatesDispersal from the natal site or familial group is a core milestone of adolescent development in many species. A wild species of mouse, Mus spicilegus, presents an exciting model in which to study adolescent development and dispersal because it shows different life history trajectory depending on season of birth. M. spicilegus born in spring and summer on long days (LD) disperse in the first 3 months of life, while M. spicilegus born on shorter autumnal days (SD) delay dispersal through the wintertime. We were interested in using these mice in a laboratory context to compare age-matched mice with differential motivation to disperse. To first test if we could find a proxy for dispersal related behavior in the laboratory environment, we measured open field and novel object investigation across development in M. spicilegus raised on a LD 12 h:12 h light:dark cycle. We found that between the first and second month of life, distance traveled and time in center of the open field increased significantly with age in M. spicilegus. Robust novel object investigation was observed in all age groups and decreased between the 2nd and 3rd month of life in LD males. Compared to male C57BL/6 mice, male M. spicilegus traveled significantly longer distances in the open field but spent less time in the center of the field. However, when a novel object was placed in the center of the open field, Male M. spicilegus, were significantly more willing to contact and mount it. To test if autumnal photoperiod affects exploratory behavior in M. spicilegus in a laboratory environment, we reared a cohort of M. spicilegus on a SD 10 h:14 h photoperiod and tested their exploratory behavior at P60-70. At this timepoint, we found SD rearing had no effect on open field metrics, but led to reduced novel object investigation. We also observed that in P60-70 males, SD reared M. spicilegus weighed less than LD reared M. spicilegus. These observations establish that SD photoperiod can delay weight gain and blunt some, but not all forms of exploratory behavior in adolescent M. spicilegus.https://www.frontiersin.org/articles/10.3389/fnbeh.2022.988033/fulldispersalseasonalityadolescenceopen fieldnovel objectwild mouse |
| spellingShingle | Noah G. Cryns Wan Chen Lin Niloofar Motahari Oliver J. Krentzman Weihang Chen George Prounis Linda Wilbrecht Linda Wilbrecht The maturation of exploratory behavior in adolescent Mus spicilegus on two photoperiods Frontiers in Behavioral Neuroscience dispersal seasonality adolescence open field novel object wild mouse |
| title | The maturation of exploratory behavior in adolescent Mus spicilegus on two photoperiods |
| title_full | The maturation of exploratory behavior in adolescent Mus spicilegus on two photoperiods |
| title_fullStr | The maturation of exploratory behavior in adolescent Mus spicilegus on two photoperiods |
| title_full_unstemmed | The maturation of exploratory behavior in adolescent Mus spicilegus on two photoperiods |
| title_short | The maturation of exploratory behavior in adolescent Mus spicilegus on two photoperiods |
| title_sort | maturation of exploratory behavior in adolescent mus spicilegus on two photoperiods |
| topic | dispersal seasonality adolescence open field novel object wild mouse |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.988033/full |
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