Application of Single-Cell Genomics in Cardiovascular Research
Abstract Cardiovascular diseases (CVDs) are the leading cause of death in the global world. The emergence of single-cell technologies has greatly facilitated the research on CVDs. Currently, those single-cell technologies have been widely applied in atherosclerosis, myocardial infarction, cardiac is...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-01-01
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| Series: | Cardiology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40119-023-00303-y |
| _version_ | 1797863284452360192 |
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| author | Xuejing Yu Xianggui Yang Jinjin Cao |
| author_facet | Xuejing Yu Xianggui Yang Jinjin Cao |
| author_sort | Xuejing Yu |
| collection | DOAJ |
| description | Abstract Cardiovascular diseases (CVDs) are the leading cause of death in the global world. The emergence of single-cell technologies has greatly facilitated the research on CVDs. Currently, those single-cell technologies have been widely applied in atherosclerosis, myocardial infarction, cardiac ischemia–reperfusion injury, arrhythmia, hypertrophy cardiomyopathy, and heart failure, which are extremely helpful in elucidating the underlying mechanisms of CVDs from physiological and pathological perspectives at DNA, RNA, protein, post-transcriptional, post-translational, and metabolite levels. In this review, we would like to briefly introduce the current single-cell technologies, and will focus on the utilization of single-cell genomics in various heart diseases. Single-cell technologies have great potential in exploration of CVDs, and widespread application of single-cell genomics will promote the understanding and therapeutic treatments for CVDs. |
| first_indexed | 2024-04-09T22:33:06Z |
| format | Article |
| id | doaj.art-a5e559a426434cc99df9fccfd5c3624b |
| institution | Directory Open Access Journal |
| issn | 2193-8261 2193-6544 |
| language | English |
| last_indexed | 2024-04-09T22:33:06Z |
| publishDate | 2023-01-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Cardiology and Therapy |
| spelling | doaj.art-a5e559a426434cc99df9fccfd5c3624b2023-03-22T12:39:36ZengAdis, Springer HealthcareCardiology and Therapy2193-82612193-65442023-01-0112110112510.1007/s40119-023-00303-yApplication of Single-Cell Genomics in Cardiovascular ResearchXuejing Yu0Xianggui Yang1Jinjin Cao2Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical CenterDepartment of Laboratory Medicine, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical CollegeDepartment of Radiology, Division of Abdominal Imaging, Massachusetts General HospitalAbstract Cardiovascular diseases (CVDs) are the leading cause of death in the global world. The emergence of single-cell technologies has greatly facilitated the research on CVDs. Currently, those single-cell technologies have been widely applied in atherosclerosis, myocardial infarction, cardiac ischemia–reperfusion injury, arrhythmia, hypertrophy cardiomyopathy, and heart failure, which are extremely helpful in elucidating the underlying mechanisms of CVDs from physiological and pathological perspectives at DNA, RNA, protein, post-transcriptional, post-translational, and metabolite levels. In this review, we would like to briefly introduce the current single-cell technologies, and will focus on the utilization of single-cell genomics in various heart diseases. Single-cell technologies have great potential in exploration of CVDs, and widespread application of single-cell genomics will promote the understanding and therapeutic treatments for CVDs.https://doi.org/10.1007/s40119-023-00303-ySingle-cell technologiesSingle-cell genomicsCardiovascular diseasesHeart diseasesMyocardial infarctionCardiac ischemia reperfusion injury |
| spellingShingle | Xuejing Yu Xianggui Yang Jinjin Cao Application of Single-Cell Genomics in Cardiovascular Research Cardiology and Therapy Single-cell technologies Single-cell genomics Cardiovascular diseases Heart diseases Myocardial infarction Cardiac ischemia reperfusion injury |
| title | Application of Single-Cell Genomics in Cardiovascular Research |
| title_full | Application of Single-Cell Genomics in Cardiovascular Research |
| title_fullStr | Application of Single-Cell Genomics in Cardiovascular Research |
| title_full_unstemmed | Application of Single-Cell Genomics in Cardiovascular Research |
| title_short | Application of Single-Cell Genomics in Cardiovascular Research |
| title_sort | application of single cell genomics in cardiovascular research |
| topic | Single-cell technologies Single-cell genomics Cardiovascular diseases Heart diseases Myocardial infarction Cardiac ischemia reperfusion injury |
| url | https://doi.org/10.1007/s40119-023-00303-y |
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