H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer
Abstract Background Breast cancer (BC) is the most frequent malignancy occurring in women worldwide. Emerging evidence indicates that small nucleolar RNAs (snoRNAs) play a role in tumor development. In the current study, we evaluated expression profiles and functions of snoRNAs associated with BC. M...
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12935-019-0830-1 |
| _version_ | 1819151644874506240 |
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| author | Yihan Sun Endong Chen Yuefeng Li Danrong Ye Yefeng Cai Qingxuan Wang Quan Li Xiaohua Zhang |
| author_facet | Yihan Sun Endong Chen Yuefeng Li Danrong Ye Yefeng Cai Qingxuan Wang Quan Li Xiaohua Zhang |
| author_sort | Yihan Sun |
| collection | DOAJ |
| description | Abstract Background Breast cancer (BC) is the most frequent malignancy occurring in women worldwide. Emerging evidence indicates that small nucleolar RNAs (snoRNAs) play a role in tumor development. In the current study, we evaluated expression profiles and functions of snoRNAs associated with BC. Methods We analyzed the expression levels of snoRNAs between breast cancer and normal tissues in TCGA database and found that SNORA7B is upregulated in BC. We confirmed this result in clinical cancer tissues and BC cell lines via qRT-PCR. Then, we investigated clinical significance in public datasets and biological function of SNORA7B using a series of in vitro gain- and loss-of-function experiments. Results SNORA7B expression was significantly upregulated in samples from patients with BC in both public database and our clinical tissues compared to its expression in normal tissues. Meanwhile, patients with high SNORA7B expression have worse prognosis. Inhibition of SNORA7B expression impaired cell growth, proliferation, migration, and invasion via inducing apoptosis. Conclusions SNORA7B functions as an important oncogenic snoRNA in BC and may serve as a potential prognosis biomarker for BC. |
| first_indexed | 2024-12-22T14:36:41Z |
| format | Article |
| id | doaj.art-a5e5f4301c044395ba438e12d9605ca0 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-22T14:36:41Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-a5e5f4301c044395ba438e12d9605ca02022-12-21T18:22:37ZengBMCCancer Cell International1475-28672019-05-0119111210.1186/s12935-019-0830-1H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancerYihan Sun0Endong Chen1Yuefeng Li2Danrong Ye3Yefeng Cai4Qingxuan Wang5Quan Li6Xiaohua Zhang7Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Background Breast cancer (BC) is the most frequent malignancy occurring in women worldwide. Emerging evidence indicates that small nucleolar RNAs (snoRNAs) play a role in tumor development. In the current study, we evaluated expression profiles and functions of snoRNAs associated with BC. Methods We analyzed the expression levels of snoRNAs between breast cancer and normal tissues in TCGA database and found that SNORA7B is upregulated in BC. We confirmed this result in clinical cancer tissues and BC cell lines via qRT-PCR. Then, we investigated clinical significance in public datasets and biological function of SNORA7B using a series of in vitro gain- and loss-of-function experiments. Results SNORA7B expression was significantly upregulated in samples from patients with BC in both public database and our clinical tissues compared to its expression in normal tissues. Meanwhile, patients with high SNORA7B expression have worse prognosis. Inhibition of SNORA7B expression impaired cell growth, proliferation, migration, and invasion via inducing apoptosis. Conclusions SNORA7B functions as an important oncogenic snoRNA in BC and may serve as a potential prognosis biomarker for BC.http://link.springer.com/article/10.1186/s12935-019-0830-1Small nucleolar RNABreast cancerSNORA7BOncogenicApoptosis |
| spellingShingle | Yihan Sun Endong Chen Yuefeng Li Danrong Ye Yefeng Cai Qingxuan Wang Quan Li Xiaohua Zhang H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer Cancer Cell International Small nucleolar RNA Breast cancer SNORA7B Oncogenic Apoptosis |
| title | H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer |
| title_full | H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer |
| title_fullStr | H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer |
| title_full_unstemmed | H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer |
| title_short | H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer |
| title_sort | h aca box small nucleolar rna 7b acts as an oncogene and a potential prognostic biomarker in breast cancer |
| topic | Small nucleolar RNA Breast cancer SNORA7B Oncogenic Apoptosis |
| url | http://link.springer.com/article/10.1186/s12935-019-0830-1 |
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