<i>Snail-1</i> Overexpression Correlates with Metastatic Phenotype in BRAF<sup>V600E</sup> Positive Papillary Thyroid Carcinoma
The ability of cancer to metastasize is regulated by various signaling pathways, including transforming growth factor β (TGFβ), also implicated in the upregulation of Snail-1 transcription factor in malignant neoplasms. B-type Raf kinase gene (BRAF)<sup>V600E</sup>, the most common drivi...
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MDPI AG
2020-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/9/2701 |
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| author | Katarzyna Wieczorek-Szukala Janusz Kopczynski Aldona Kowalska Andrzej Lewinski |
| author_facet | Katarzyna Wieczorek-Szukala Janusz Kopczynski Aldona Kowalska Andrzej Lewinski |
| author_sort | Katarzyna Wieczorek-Szukala |
| collection | DOAJ |
| description | The ability of cancer to metastasize is regulated by various signaling pathways, including transforming growth factor β (TGFβ), also implicated in the upregulation of Snail-1 transcription factor in malignant neoplasms. B-type Raf kinase gene (BRAF)<sup>V600E</sup>, the most common driving mutation in papillary thyroid carcinoma (PTC), induces epithelial to mesenchymal transition (EMT) in thyroid cancer cells through changes in the Snail-1 level, increasing cell migration and invasion. However, little is known about the mechanism of Snail-1 and BRAF<sup>V600E</sup> relations in humans. Our study included 61 PTC patients with evaluated BRAF<sup>V600E</sup> mutation status. A total of 18 of those patients had lymph node metastases—of whom 10 were BRAF<sup>V600E</sup> positive, and 8 negative. Our findings indicate that the expression of Snail-1, but not TGFβ1, correlates with the metastatic phenotype in PTC. This is the first piece of evidence that the upregulation of Snail-1 corresponds with the presence of BRAF<sup>V600E</sup> mutation and increased expression of Snail-1 in metastatic PTC samples is dependent on BRAF<sup>V600E</sup> mutation status. |
| first_indexed | 2024-03-10T17:04:08Z |
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| id | doaj.art-a5e82426e00948efaaab8119f0acad97 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T17:04:08Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a5e82426e00948efaaab8119f0acad972023-11-20T10:51:48ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0199270110.3390/jcm9092701<i>Snail-1</i> Overexpression Correlates with Metastatic Phenotype in BRAF<sup>V600E</sup> Positive Papillary Thyroid CarcinomaKatarzyna Wieczorek-Szukala0Janusz Kopczynski1Aldona Kowalska2Andrzej Lewinski3Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, PolandDepartment of Pathology, Holy Cross Cancer Center, 25-734 Kielce, PolandEndocrinology Clinic, Holy Cross Cancer Center, 25-734 Kielce, PolandDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, PolandThe ability of cancer to metastasize is regulated by various signaling pathways, including transforming growth factor β (TGFβ), also implicated in the upregulation of Snail-1 transcription factor in malignant neoplasms. B-type Raf kinase gene (BRAF)<sup>V600E</sup>, the most common driving mutation in papillary thyroid carcinoma (PTC), induces epithelial to mesenchymal transition (EMT) in thyroid cancer cells through changes in the Snail-1 level, increasing cell migration and invasion. However, little is known about the mechanism of Snail-1 and BRAF<sup>V600E</sup> relations in humans. Our study included 61 PTC patients with evaluated BRAF<sup>V600E</sup> mutation status. A total of 18 of those patients had lymph node metastases—of whom 10 were BRAF<sup>V600E</sup> positive, and 8 negative. Our findings indicate that the expression of Snail-1, but not TGFβ1, correlates with the metastatic phenotype in PTC. This is the first piece of evidence that the upregulation of Snail-1 corresponds with the presence of BRAF<sup>V600E</sup> mutation and increased expression of Snail-1 in metastatic PTC samples is dependent on BRAF<sup>V600E</sup> mutation status.https://www.mdpi.com/2077-0383/9/9/2701PTCthyroidmetastasisSnail-1BRAF<sup>V600E</sup> |
| spellingShingle | Katarzyna Wieczorek-Szukala Janusz Kopczynski Aldona Kowalska Andrzej Lewinski <i>Snail-1</i> Overexpression Correlates with Metastatic Phenotype in BRAF<sup>V600E</sup> Positive Papillary Thyroid Carcinoma Journal of Clinical Medicine PTC thyroid metastasis Snail-1 BRAF<sup>V600E</sup> |
| title | <i>Snail-1</i> Overexpression Correlates with Metastatic Phenotype in BRAF<sup>V600E</sup> Positive Papillary Thyroid Carcinoma |
| title_full | <i>Snail-1</i> Overexpression Correlates with Metastatic Phenotype in BRAF<sup>V600E</sup> Positive Papillary Thyroid Carcinoma |
| title_fullStr | <i>Snail-1</i> Overexpression Correlates with Metastatic Phenotype in BRAF<sup>V600E</sup> Positive Papillary Thyroid Carcinoma |
| title_full_unstemmed | <i>Snail-1</i> Overexpression Correlates with Metastatic Phenotype in BRAF<sup>V600E</sup> Positive Papillary Thyroid Carcinoma |
| title_short | <i>Snail-1</i> Overexpression Correlates with Metastatic Phenotype in BRAF<sup>V600E</sup> Positive Papillary Thyroid Carcinoma |
| title_sort | i snail 1 i overexpression correlates with metastatic phenotype in braf sup v600e sup positive papillary thyroid carcinoma |
| topic | PTC thyroid metastasis Snail-1 BRAF<sup>V600E</sup> |
| url | https://www.mdpi.com/2077-0383/9/9/2701 |
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