Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse
The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. The discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet the cellular substrate of these early interactio...
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| Format: | Article |
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eLife Sciences Publications Ltd
2018-04-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/33158 |
| _version_ | 1811199826958745600 |
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| author | Joachim Ahlbeck Lingzhen Song Mattia Chini Sebastian H Bitzenhofer Ileana L Hanganu-Opatz |
| author_facet | Joachim Ahlbeck Lingzhen Song Mattia Chini Sebastian H Bitzenhofer Ileana L Hanganu-Opatz |
| author_sort | Joachim Ahlbeck |
| collection | DOAJ |
| description | The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. The discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet the cellular substrate of these early interactions is still unresolved. Here, we selectively target optogenetic manipulation of glutamatergic projection neurons in the CA1 area of either dorsal or intermediate/ventral hippocampus at neonatal age to elucidate their contribution to the emergence of prefrontal oscillatory entrainment. We show that despite stronger theta and ripples power in dorsal hippocampus, the prefrontal cortex is mainly coupled with intermediate/ventral hippocampus by phase-locking of neuronal firing via dense direct axonal projections. Theta band-confined activation by light of pyramidal neurons in intermediate/ventral but not dorsal CA1 that were transfected by in utero electroporation with high-efficiency channelrhodopsin boosts prefrontal oscillations. Our data causally elucidate the cellular origin of the long-range coupling in the developing brain. |
| first_indexed | 2024-04-12T01:54:00Z |
| format | Article |
| id | doaj.art-a5e95be27d3c4d459fc63808fdb9fa7b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:54:00Z |
| publishDate | 2018-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-a5e95be27d3c4d459fc63808fdb9fa7b2022-12-22T03:52:51ZengeLife Sciences Publications LtdeLife2050-084X2018-04-01710.7554/eLife.33158Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouseJoachim Ahlbeck0https://orcid.org/0000-0002-4439-0798Lingzhen Song1Mattia Chini2https://orcid.org/0000-0002-5782-9720Sebastian H Bitzenhofer3Ileana L Hanganu-Opatz4https://orcid.org/0000-0002-4787-1765Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyThe long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. The discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet the cellular substrate of these early interactions is still unresolved. Here, we selectively target optogenetic manipulation of glutamatergic projection neurons in the CA1 area of either dorsal or intermediate/ventral hippocampus at neonatal age to elucidate their contribution to the emergence of prefrontal oscillatory entrainment. We show that despite stronger theta and ripples power in dorsal hippocampus, the prefrontal cortex is mainly coupled with intermediate/ventral hippocampus by phase-locking of neuronal firing via dense direct axonal projections. Theta band-confined activation by light of pyramidal neurons in intermediate/ventral but not dorsal CA1 that were transfected by in utero electroporation with high-efficiency channelrhodopsin boosts prefrontal oscillations. Our data causally elucidate the cellular origin of the long-range coupling in the developing brain.https://elifesciences.org/articles/33158cortical developmentoptogeneticsoscillationsprefrontalhippocampal |
| spellingShingle | Joachim Ahlbeck Lingzhen Song Mattia Chini Sebastian H Bitzenhofer Ileana L Hanganu-Opatz Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse eLife cortical development optogenetics oscillations prefrontal hippocampal |
| title | Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse |
| title_full | Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse |
| title_fullStr | Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse |
| title_full_unstemmed | Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse |
| title_short | Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse |
| title_sort | glutamatergic drive along the septo temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse |
| topic | cortical development optogenetics oscillations prefrontal hippocampal |
| url | https://elifesciences.org/articles/33158 |
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