Oxidative Stress and Inflammatory Modulation of Ca<sup>2+</sup> Handling in Metabolic HFpEF-Related Left Atrial Cardiomyopathy

Oxidative Stress and Inflammatory Modulation of Ca<sup>2+</sup> Handling in Metabolic HFpEF-Related Left Atrial Cardiomyopathy

Metabolic syndrome-mediated heart failure with preserved ejection fraction (HFpEF) is commonly accompanied by left atrial (LA) cardiomyopathy, significantly affecting morbidity and mortality. We evaluate the role of reactive oxygen species (ROS) and intrinsic inflammation (TNF-α, IL-10) related to d...

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Bibliographic Details
Main Authors: David Bode, Yan Wen, Niklas Hegemann, Uwe Primessnig, Abdul Parwani, Leif-Hendrik Boldt, Burkert M. Pieske, Frank R. Heinzel, Felix Hohendanner
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antioxidants
Subjects:
inflammation
reactive oxygen species
atrial cardiomyopathy
heart failure with preserved ejection fraction (HFpEF)
metabolic syndrome
excitation-contraction coupling
Online Access:https://www.mdpi.com/2076-3921/9/9/860

Internet

https://www.mdpi.com/2076-3921/9/9/860

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