Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model
Due to the demonstrated intestinal microbial transformation of strawberry ellagitannins (ET) into bioactive metabolites, in the current study on rats, we hypothesised that the dietary addition of a strawberry ET-rich extract (S-ET) to a high-fat diet (HFD) would attenuate disturbances in the redox a...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/24/5874 |
| _version_ | 1827700276176355328 |
|---|---|
| author | Ewa Żary-Sikorska Bartosz Fotschki Adam Jurgoński Monika Kosmala Joanna Milala Krzysztof Kołodziejczyk Michał Majewski Katarzyna Ognik Jerzy Juśkiewicz |
| author_facet | Ewa Żary-Sikorska Bartosz Fotschki Adam Jurgoński Monika Kosmala Joanna Milala Krzysztof Kołodziejczyk Michał Majewski Katarzyna Ognik Jerzy Juśkiewicz |
| author_sort | Ewa Żary-Sikorska |
| collection | DOAJ |
| description | Due to the demonstrated intestinal microbial transformation of strawberry ellagitannins (ET) into bioactive metabolites, in the current study on rats, we hypothesised that the dietary addition of a strawberry ET-rich extract (S-ET) to a high-fat diet (HFD) would attenuate disturbances in the redox and lipid status as well as in the inflammatory response. We randomly distributed 48 Wistar rats into six groups and used two-way analysis of variance (ANOVA) to assess the effects of two main factors—diet type (standard and high-fat) and ET dosage (without, low, and 3× higher)—applied to rats for 4 weeks. In relation to the hypothesis, irrespective of the dosage, the dietary application of ET resulted in the desired attenuating effects in rats fed a HFD as manifested by decreased body weight gain, relative mass of the epididymal pad, hepatic fat, oxidized glutathione (GSSG), triglycerides (TG), total cholesterol (TC), and thiobarbituric acid-reactive substances (TBARS) concentrations as well as desired modifications in the blood plasma parameters. These beneficial changes were enhanced by the high dietary addition of ET, which was associated with considerably higher concentrations of ET metabolites in the urine and plasma of rats. The results indicated that S-ET could be effectively used for the prevention and treatment of metabolic disturbances associated with obesity, dyslipidaemia, redox status imbalance, and inflammation. |
| first_indexed | 2024-03-10T14:08:00Z |
| format | Article |
| id | doaj.art-a5ea105e23c54248a615682f3b1c2054 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:08:00Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a5ea105e23c54248a615682f3b1c20542023-11-21T00:28:10ZengMDPI AGMolecules1420-30492020-12-012524587410.3390/molecules25245874Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat ModelEwa Żary-Sikorska0Bartosz Fotschki1Adam Jurgoński2Monika Kosmala3Joanna Milala4Krzysztof Kołodziejczyk5Michał Majewski6Katarzyna Ognik7Jerzy Juśkiewicz8Department of Microbiology and Food Technology, Faculty of Agriculture and Biotechnology, University of Science and Technology, Al. Prof. S. Kaliskiego 7, 85-796 Bydgoszcz, PolandDivision of Food Science, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, PolandDivision of Food Science, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, PolandInstitute of Food Technology and Analysis, Lodz University of Technology, Stefanowskiego 4/10, 90-924 Łódź, PolandInstitute of Food Technology and Analysis, Lodz University of Technology, Stefanowskiego 4/10, 90-924 Łódź, PolandInstitute of Food Technology and Analysis, Lodz University of Technology, Stefanowskiego 4/10, 90-924 Łódź, PolandDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury, Warszawska 30, 10-082 Olsztyn, PolandDepartment of Biochemistry and Toxicology, Faculty of Biology, Animal Sciences and Bioeconomy, University of Life Sciences, Akademicka 13, 20-950 Lublin, PolandDivision of Food Science, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, PolandDue to the demonstrated intestinal microbial transformation of strawberry ellagitannins (ET) into bioactive metabolites, in the current study on rats, we hypothesised that the dietary addition of a strawberry ET-rich extract (S-ET) to a high-fat diet (HFD) would attenuate disturbances in the redox and lipid status as well as in the inflammatory response. We randomly distributed 48 Wistar rats into six groups and used two-way analysis of variance (ANOVA) to assess the effects of two main factors—diet type (standard and high-fat) and ET dosage (without, low, and 3× higher)—applied to rats for 4 weeks. In relation to the hypothesis, irrespective of the dosage, the dietary application of ET resulted in the desired attenuating effects in rats fed a HFD as manifested by decreased body weight gain, relative mass of the epididymal pad, hepatic fat, oxidized glutathione (GSSG), triglycerides (TG), total cholesterol (TC), and thiobarbituric acid-reactive substances (TBARS) concentrations as well as desired modifications in the blood plasma parameters. These beneficial changes were enhanced by the high dietary addition of ET, which was associated with considerably higher concentrations of ET metabolites in the urine and plasma of rats. The results indicated that S-ET could be effectively used for the prevention and treatment of metabolic disturbances associated with obesity, dyslipidaemia, redox status imbalance, and inflammation.https://www.mdpi.com/1420-3049/25/24/5874rat modelgastrointestinal tracthigh-fat-dietstrawberry extractellagitanninsnasutin A |
| spellingShingle | Ewa Żary-Sikorska Bartosz Fotschki Adam Jurgoński Monika Kosmala Joanna Milala Krzysztof Kołodziejczyk Michał Majewski Katarzyna Ognik Jerzy Juśkiewicz Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model Molecules rat model gastrointestinal tract high-fat-diet strawberry extract ellagitannins nasutin A |
| title | Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model |
| title_full | Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model |
| title_fullStr | Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model |
| title_full_unstemmed | Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model |
| title_short | Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model |
| title_sort | protective effects of a strawberry ellagitannin rich extract against pro oxidative and pro inflammatory dysfunctions induced by a high fat diet in a rat model |
| topic | rat model gastrointestinal tract high-fat-diet strawberry extract ellagitannins nasutin A |
| url | https://www.mdpi.com/1420-3049/25/24/5874 |
| work_keys_str_mv | AT ewazarysikorska protectiveeffectsofastrawberryellagitanninrichextractagainstprooxidativeandproinflammatorydysfunctionsinducedbyahighfatdietinaratmodel AT bartoszfotschki protectiveeffectsofastrawberryellagitanninrichextractagainstprooxidativeandproinflammatorydysfunctionsinducedbyahighfatdietinaratmodel AT adamjurgonski protectiveeffectsofastrawberryellagitanninrichextractagainstprooxidativeandproinflammatorydysfunctionsinducedbyahighfatdietinaratmodel AT monikakosmala protectiveeffectsofastrawberryellagitanninrichextractagainstprooxidativeandproinflammatorydysfunctionsinducedbyahighfatdietinaratmodel AT joannamilala protectiveeffectsofastrawberryellagitanninrichextractagainstprooxidativeandproinflammatorydysfunctionsinducedbyahighfatdietinaratmodel AT krzysztofkołodziejczyk protectiveeffectsofastrawberryellagitanninrichextractagainstprooxidativeandproinflammatorydysfunctionsinducedbyahighfatdietinaratmodel AT michałmajewski protectiveeffectsofastrawberryellagitanninrichextractagainstprooxidativeandproinflammatorydysfunctionsinducedbyahighfatdietinaratmodel AT katarzynaognik protectiveeffectsofastrawberryellagitanninrichextractagainstprooxidativeandproinflammatorydysfunctionsinducedbyahighfatdietinaratmodel AT jerzyjuskiewicz protectiveeffectsofastrawberryellagitanninrichextractagainstprooxidativeandproinflammatorydysfunctionsinducedbyahighfatdietinaratmodel |