Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis
Abstract Background This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). Methods A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relev...
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-018-4670-5 |
| _version_ | 1818983728648552448 |
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| author | Zhenglei Shen Xuezhong Gu Wenwen Mao Liefen Yin Ling Yang Zhe Zhang Kunmei Liu Lilan Wang Yunchao Huang |
| author_facet | Zhenglei Shen Xuezhong Gu Wenwen Mao Liefen Yin Ling Yang Zhe Zhang Kunmei Liu Lilan Wang Yunchao Huang |
| author_sort | Zhenglei Shen |
| collection | DOAJ |
| description | Abstract Background This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). Methods A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database inception to March 2016. A total of 21 studies were included. Results Patients with positive MRD prior to allogeneic stem cell transplantation (allo-SCT) had a significantly higher rate of relapse compared with those with negative MRD (HR = 3.26; P < 0.05). Pre-transplantation positive MRD was a significant negative predictor of relapse-free survival (RFS) (HR = 2.53; P < 0.05), event-free survival (EFS) (HR = 4.77; P < 0.05), and overall survival (OS) (HR = 1.98; P < 0.05). However, positive MRD prior to transplantation was not associated with a higher rate of nonrelapse mortality. Conclusions Positive MRD before allo-SCT was a predictor of poor prognosis after transplantation in ALL. Trial registration Not applicable. |
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| id | doaj.art-a5eab727d2f64f149a8883834e9ce9e3 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-20T18:07:43Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj.art-a5eab727d2f64f149a8883834e9ce9e32022-12-21T19:30:33ZengBMCBMC Cancer1471-24072018-07-0118111210.1186/s12885-018-4670-5Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysisZhenglei Shen0Xuezhong Gu1Wenwen Mao2Liefen Yin3Ling Yang4Zhe Zhang5Kunmei Liu6Lilan Wang7Yunchao Huang8Department of Hematology, The Third Affiliated Hospital of Kunming Medical UniversityDepartment of Hematology, The First People Hospital in Yunnan ProvinceDepartment of Geriatrics, The Second Hospital of KunmingDepartment of Hematology, The Second Affiliated Hospital of Kunming Medical UniversityDepartment of Hematology, The Second Affiliated Hospital of Kunming Medical UniversityDepartment of Hematology, The Second Affiliated Hospital of Kunming Medical UniversityDepartment of Hematology, The Third Affiliated Hospital of Kunming Medical UniversityDepartment of Chest Surgery, The Third Affiliated Hospital of Kunming Medical UniversityDepartment of Chest Surgery, The Third Affiliated Hospital of Kunming Medical UniversityAbstract Background This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). Methods A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database inception to March 2016. A total of 21 studies were included. Results Patients with positive MRD prior to allogeneic stem cell transplantation (allo-SCT) had a significantly higher rate of relapse compared with those with negative MRD (HR = 3.26; P < 0.05). Pre-transplantation positive MRD was a significant negative predictor of relapse-free survival (RFS) (HR = 2.53; P < 0.05), event-free survival (EFS) (HR = 4.77; P < 0.05), and overall survival (OS) (HR = 1.98; P < 0.05). However, positive MRD prior to transplantation was not associated with a higher rate of nonrelapse mortality. Conclusions Positive MRD before allo-SCT was a predictor of poor prognosis after transplantation in ALL. Trial registration Not applicable.http://link.springer.com/article/10.1186/s12885-018-4670-5Acute lymphoblastic leukemiaAllogeneic stem cell transplantationMinimal residual disease |
| spellingShingle | Zhenglei Shen Xuezhong Gu Wenwen Mao Liefen Yin Ling Yang Zhe Zhang Kunmei Liu Lilan Wang Yunchao Huang Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis BMC Cancer Acute lymphoblastic leukemia Allogeneic stem cell transplantation Minimal residual disease |
| title | Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis |
| title_full | Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis |
| title_fullStr | Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis |
| title_full_unstemmed | Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis |
| title_short | Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis |
| title_sort | influence of pre transplant minimal residual disease on prognosis after allo sct for patients with acute lymphoblastic leukemia systematic review and meta analysis |
| topic | Acute lymphoblastic leukemia Allogeneic stem cell transplantation Minimal residual disease |
| url | http://link.springer.com/article/10.1186/s12885-018-4670-5 |
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