Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels
The controlled release of a compound entrapped in a biocompatible formulation is a sought-after goal in modern pharmaceutical technology. Zein is a hydrophobic protein which has several advantageous properties that make it suitable for use as a biocompatible and degradable material under physiologic...
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MDPI AG
2020-07-01
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Series: | Molecules |
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Online Access: | https://www.mdpi.com/1420-3049/25/14/3174 |
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author | Agnese Gagliardi Silvia Voci Donatella Paolino Massimo Fresta Donato Cosco |
author_facet | Agnese Gagliardi Silvia Voci Donatella Paolino Massimo Fresta Donato Cosco |
author_sort | Agnese Gagliardi |
collection | DOAJ |
description | The controlled release of a compound entrapped in a biocompatible formulation is a sought-after goal in modern pharmaceutical technology. Zein is a hydrophobic protein which has several advantageous properties that make it suitable for use as a biocompatible and degradable material under physiological conditions. It is, therefore, proposed for different biomedical and pharmaceutical applications. In particular, due to its gelling properties, it can be used to form a polymeric network able to preserve biomolecules from harsh environments. The current study was designed to investigate the influence of different probes on the rheological properties of gels made up of zein, in order to characterize the systems as a function of the polymer concentration. Four model compounds characterized by different physico-chemical properties were entrapped in zein gels, and different behaviors (viscoelastic or pronounced solid-like characteristics) of the systems were observed. Zein-based gels showed various release profiles of the encapsulated compounds, suggesting that there are different interaction rates between the probes and the polymeric matrix. |
first_indexed | 2024-03-10T18:32:48Z |
format | Article |
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issn | 1420-3049 |
language | English |
last_indexed | 2024-03-10T18:32:48Z |
publishDate | 2020-07-01 |
publisher | MDPI AG |
record_format | Article |
series | Molecules |
spelling | doaj.art-a5eeaf5607de4170a3bdc4095b23a6412023-11-20T06:31:23ZengMDPI AGMolecules1420-30492020-07-012514317410.3390/molecules25143174Influence of Various Model Compounds on the Rheological Properties of Zein-Based GelsAgnese Gagliardi0Silvia Voci1Donatella Paolino2Massimo Fresta3Donato Cosco4Department of Experimental and Clinical Medicine, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, I-88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario “SVenuta”, I-88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, I-88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario “SVenuta”, I-88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario “SVenuta”, I-88100 Catanzaro, ItalyThe controlled release of a compound entrapped in a biocompatible formulation is a sought-after goal in modern pharmaceutical technology. Zein is a hydrophobic protein which has several advantageous properties that make it suitable for use as a biocompatible and degradable material under physiological conditions. It is, therefore, proposed for different biomedical and pharmaceutical applications. In particular, due to its gelling properties, it can be used to form a polymeric network able to preserve biomolecules from harsh environments. The current study was designed to investigate the influence of different probes on the rheological properties of gels made up of zein, in order to characterize the systems as a function of the polymer concentration. Four model compounds characterized by different physico-chemical properties were entrapped in zein gels, and different behaviors (viscoelastic or pronounced solid-like characteristics) of the systems were observed. Zein-based gels showed various release profiles of the encapsulated compounds, suggesting that there are different interaction rates between the probes and the polymeric matrix.https://www.mdpi.com/1420-3049/25/14/3174controlled releasegelspolymeric matrixprobesrheologyzein |
spellingShingle | Agnese Gagliardi Silvia Voci Donatella Paolino Massimo Fresta Donato Cosco Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels Molecules controlled release gels polymeric matrix probes rheology zein |
title | Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels |
title_full | Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels |
title_fullStr | Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels |
title_full_unstemmed | Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels |
title_short | Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels |
title_sort | influence of various model compounds on the rheological properties of zein based gels |
topic | controlled release gels polymeric matrix probes rheology zein |
url | https://www.mdpi.com/1420-3049/25/14/3174 |
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