AGING WITH HEMOPHILIA: THE CHALLENGE OF APPROPRIATE DRUG PRESCRIPTION
In high-income countries persons with severe hemophilia (PWH) A and B are aging, like their age-matched peers without hemophilia from the general population. Aging is associated not only with the comorbidities stemming from their inherited bleeding disorder (arthropathy, chronic viral infections suc...
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| Формат: | Стаття |
| Мова: | English |
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PAGEPress Publications
2019-08-01
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| Серія: | Mediterranean Journal of Hematology and Infectious Diseases |
| Предмети: | |
| Онлайн доступ: | http://mjhid.org/index.php/mjhid/article/view/4009 |
| _version_ | 1826908860740272128 |
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| author | Pier Mannuccio Mannucci |
| author_facet | Pier Mannuccio Mannucci |
| author_sort | Pier Mannuccio Mannucci |
| collection | DOAJ |
| description | In high-income countries persons with severe hemophilia (PWH) A and B are aging, like their age-matched peers without hemophilia from the general population. Aging is associated not only with the comorbidities stemming from their inherited bleeding disorder (arthropathy, chronic viral infections such as hepatitis and AIDS) but also with the multiple chronic ailments associated with aging (cancer, cardiovascular disease, COPD). Multimorbidity is inevitably associated with polypharmacy, i.e., the chronic daily intake of at least five drugs, and with the related risk of severe adverse events associated with the use of inappropriate drugs and drug-drug interactions. Information on the pattern of drug prescription and usage by PWH is relatively scanty, but on the whole, the available data indicate that the rate of polypharmacy, as well as the risk of drug-drug interaction, is relatively low in PWH and better than that in their age peers without hemophilia followed by general practitioners. It is believed that this advantage results from the collaborative coordination on drug prescribing exerted, through their integration with practitioners and organ specialists, by specialized hemophilia treatment centers in the frame of comprehensive care programs. However, the available cross-sectional data were mainly obtained in relatively young PWH, so that there is a need to obtain more accurate data from the ongoing prospective studies that are being carried out in more and more progressively aging PWH.
Keywords: Hemophilia; Aging; Comorbidity; Drugs Interaction. |
| first_indexed | 2024-12-19T21:39:15Z |
| format | Article |
| id | doaj.art-a5efd901b1034fde8ce518f36dc662b0 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2025-02-17T09:31:42Z |
| publishDate | 2019-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-a5efd901b1034fde8ce518f36dc662b02025-01-02T10:41:42ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062019-08-0111110.4084/mjhid.2019.056AGING WITH HEMOPHILIA: THE CHALLENGE OF APPROPRIATE DRUG PRESCRIPTIONPier Mannuccio Mannucci0IRCCS Ca' Granda Maggiore Policlinico Hospital FoundationIn high-income countries persons with severe hemophilia (PWH) A and B are aging, like their age-matched peers without hemophilia from the general population. Aging is associated not only with the comorbidities stemming from their inherited bleeding disorder (arthropathy, chronic viral infections such as hepatitis and AIDS) but also with the multiple chronic ailments associated with aging (cancer, cardiovascular disease, COPD). Multimorbidity is inevitably associated with polypharmacy, i.e., the chronic daily intake of at least five drugs, and with the related risk of severe adverse events associated with the use of inappropriate drugs and drug-drug interactions. Information on the pattern of drug prescription and usage by PWH is relatively scanty, but on the whole, the available data indicate that the rate of polypharmacy, as well as the risk of drug-drug interaction, is relatively low in PWH and better than that in their age peers without hemophilia followed by general practitioners. It is believed that this advantage results from the collaborative coordination on drug prescribing exerted, through their integration with practitioners and organ specialists, by specialized hemophilia treatment centers in the frame of comprehensive care programs. However, the available cross-sectional data were mainly obtained in relatively young PWH, so that there is a need to obtain more accurate data from the ongoing prospective studies that are being carried out in more and more progressively aging PWH. Keywords: Hemophilia; Aging; Comorbidity; Drugs Interaction.http://mjhid.org/index.php/mjhid/article/view/4009Hemophilia; Aging; Comorbidity; Drugs Interaction. |
| spellingShingle | Pier Mannuccio Mannucci AGING WITH HEMOPHILIA: THE CHALLENGE OF APPROPRIATE DRUG PRESCRIPTION Mediterranean Journal of Hematology and Infectious Diseases Hemophilia; Aging; Comorbidity; Drugs Interaction. |
| title | AGING WITH HEMOPHILIA: THE CHALLENGE OF APPROPRIATE DRUG PRESCRIPTION |
| title_full | AGING WITH HEMOPHILIA: THE CHALLENGE OF APPROPRIATE DRUG PRESCRIPTION |
| title_fullStr | AGING WITH HEMOPHILIA: THE CHALLENGE OF APPROPRIATE DRUG PRESCRIPTION |
| title_full_unstemmed | AGING WITH HEMOPHILIA: THE CHALLENGE OF APPROPRIATE DRUG PRESCRIPTION |
| title_short | AGING WITH HEMOPHILIA: THE CHALLENGE OF APPROPRIATE DRUG PRESCRIPTION |
| title_sort | aging with hemophilia the challenge of appropriate drug prescription |
| topic | Hemophilia; Aging; Comorbidity; Drugs Interaction. |
| url | http://mjhid.org/index.php/mjhid/article/view/4009 |
| work_keys_str_mv | AT piermannucciomannucci agingwithhemophiliathechallengeofappropriatedrugprescription |