Striatal spine plasticity in Parkinson's Disease
Striatal dopamine (DA) denervation results in a significant loss of dendritic spines on medium spiny projection neurons in Parkinson’s disease (PD). In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated parkinsonian monkeys, spines contacted either by cortical or thalamic glutamatergic term...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-12-01
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| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00133/full |
| _version_ | 1828338436909563904 |
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| author | Rosa M Villalba Yoland eSmith Yoland eSmith |
| author_facet | Rosa M Villalba Yoland eSmith Yoland eSmith |
| author_sort | Rosa M Villalba |
| collection | DOAJ |
| description | Striatal dopamine (DA) denervation results in a significant loss of dendritic spines on medium spiny projection neurons in Parkinson’s disease (PD). In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated parkinsonian monkeys, spines contacted either by cortical or thalamic glutamatergic terminals are severely affected on both direct and indirect striatofugal neurons. In rodents, indirect pathway neurons appear to be more sensitive, at least in early stages of acute dopamine denervation. The remaining corticostriatal and thalamostriatal axo-spinous synapses undergo complex ultrastructural remodeling consistent with increased synaptic activity in the DA-denervated primate striatum, which may explain the pathophysiological overactivity of the corticostriatal system reported in various animal models of parkinsonism. The calcium-mediated regulation of the transcription factor myocyte enhancer factor 2 (MEF2) was recognized as a possible underlying mechanism for striatal spine plasticity. Future studies to determine how alterations in striatal spine plasticity contribute to the symptomatology of parkinsonism are warranted. |
| first_indexed | 2024-04-13T22:28:48Z |
| format | Article |
| id | doaj.art-a5eff7ecf16f49598e2eef2bc91ebf13 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-04-13T22:28:48Z |
| publishDate | 2010-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-a5eff7ecf16f49598e2eef2bc91ebf132022-12-22T02:27:00ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292010-12-01410.3389/fnana.2010.001336894Striatal spine plasticity in Parkinson's DiseaseRosa M Villalba0Yoland eSmith1Yoland eSmith2Yerkes National Primate Research Center/Emory UniversityYerkes National Primate Research Center/Emory UniversityEmory UniversityStriatal dopamine (DA) denervation results in a significant loss of dendritic spines on medium spiny projection neurons in Parkinson’s disease (PD). In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated parkinsonian monkeys, spines contacted either by cortical or thalamic glutamatergic terminals are severely affected on both direct and indirect striatofugal neurons. In rodents, indirect pathway neurons appear to be more sensitive, at least in early stages of acute dopamine denervation. The remaining corticostriatal and thalamostriatal axo-spinous synapses undergo complex ultrastructural remodeling consistent with increased synaptic activity in the DA-denervated primate striatum, which may explain the pathophysiological overactivity of the corticostriatal system reported in various animal models of parkinsonism. The calcium-mediated regulation of the transcription factor myocyte enhancer factor 2 (MEF2) was recognized as a possible underlying mechanism for striatal spine plasticity. Future studies to determine how alterations in striatal spine plasticity contribute to the symptomatology of parkinsonism are warranted.http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00133/fullDopamineGlutamateParkinson's diseaseplasticitydendritic spine |
| spellingShingle | Rosa M Villalba Yoland eSmith Yoland eSmith Striatal spine plasticity in Parkinson's Disease Frontiers in Neuroanatomy Dopamine Glutamate Parkinson's disease plasticity dendritic spine |
| title | Striatal spine plasticity in Parkinson's Disease |
| title_full | Striatal spine plasticity in Parkinson's Disease |
| title_fullStr | Striatal spine plasticity in Parkinson's Disease |
| title_full_unstemmed | Striatal spine plasticity in Parkinson's Disease |
| title_short | Striatal spine plasticity in Parkinson's Disease |
| title_sort | striatal spine plasticity in parkinson s disease |
| topic | Dopamine Glutamate Parkinson's disease plasticity dendritic spine |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00133/full |
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