Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells

Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells

Despite intensive high-dose multimodal therapy, high-risk neuroblastoma (NB) confers a less than 50% survival rate. This study investigates the role of replication stress in sensitivity to inhibition of Ataxia telangiectasia and Rad3-related (ATR) in pre-clinical models of high-risk NB. Amplificatio...

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Bibliographic Details
Main Authors: David King, Harriet E. D. Southgate, Saskia Roetschke, Polly Gravells, Leona Fields, Jessica B. Watson, Lindi Chen, Devon Chapman, Daniel Harrison, Daniel Yeomanson, Nicola J. Curtin, Deborah A. Tweddle, Helen E. Bryant
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
neuroblastoma
MYCN
replication stress
PARP
ATR
Online Access:https://www.mdpi.com/2072-6694/13/24/6215

Internet

https://www.mdpi.com/2072-6694/13/24/6215

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