The Interplay between Adeno-Associated Virus and Its Helper Viruses
The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied he...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/12/6/662 |
| _version_ | 1797564759491477504 |
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| author | Anita F. Meier Cornel Fraefel Michael Seyffert |
| author_facet | Anita F. Meier Cornel Fraefel Michael Seyffert |
| author_sort | Anita F. Meier |
| collection | DOAJ |
| description | The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses. |
| first_indexed | 2024-03-10T19:02:26Z |
| format | Article |
| id | doaj.art-a5f2211631254df8b8b3f68ffc29d3db |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T19:02:26Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a5f2211631254df8b8b3f68ffc29d3db2023-11-20T04:20:39ZengMDPI AGViruses1999-49152020-06-0112666210.3390/v12060662The Interplay between Adeno-Associated Virus and Its Helper VirusesAnita F. Meier0Cornel Fraefel1Michael Seyffert2Institute of Virology, University of Zurich, CH-8057 Zurich, SwitzerlandInstitute of Virology, University of Zurich, CH-8057 Zurich, SwitzerlandInstitute of Virology, University of Zurich, CH-8057 Zurich, SwitzerlandThe adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.https://www.mdpi.com/1999-4915/12/6/662adeno-associated virusherpes simplex virusadenovirusviral coinfectionshelper virusviral vectors |
| spellingShingle | Anita F. Meier Cornel Fraefel Michael Seyffert The Interplay between Adeno-Associated Virus and Its Helper Viruses Viruses adeno-associated virus herpes simplex virus adenovirus viral coinfections helper virus viral vectors |
| title | The Interplay between Adeno-Associated Virus and Its Helper Viruses |
| title_full | The Interplay between Adeno-Associated Virus and Its Helper Viruses |
| title_fullStr | The Interplay between Adeno-Associated Virus and Its Helper Viruses |
| title_full_unstemmed | The Interplay between Adeno-Associated Virus and Its Helper Viruses |
| title_short | The Interplay between Adeno-Associated Virus and Its Helper Viruses |
| title_sort | interplay between adeno associated virus and its helper viruses |
| topic | adeno-associated virus herpes simplex virus adenovirus viral coinfections helper virus viral vectors |
| url | https://www.mdpi.com/1999-4915/12/6/662 |
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