Engineered stem cell exosomes for oral and maxillofacial wound healing
Wound healing of the oral and maxillofacial area affects the quality of life and mental health of the patient; therefore, effective therapies are required to promote wound healing. However, traditional treatment methods have limited efficacy. Exosomes secreted by stem cells used for oral and maxillo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1038261/full |
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| author | Ming Hao Ming Hao MengNa Duan Zhijing Yang Zhijing Yang Hengzong Zhou Shuangji Li Shuangji Li Jingcheng Xiang Jingcheng Xiang Han Wu Han Wu Huimin Liu Huimin Liu Lu Chang Lu Chang Dongxu Wang Weiwei Liu Weiwei Liu |
| author_facet | Ming Hao Ming Hao MengNa Duan Zhijing Yang Zhijing Yang Hengzong Zhou Shuangji Li Shuangji Li Jingcheng Xiang Jingcheng Xiang Han Wu Han Wu Huimin Liu Huimin Liu Lu Chang Lu Chang Dongxu Wang Weiwei Liu Weiwei Liu |
| author_sort | Ming Hao |
| collection | DOAJ |
| description | Wound healing of the oral and maxillofacial area affects the quality of life and mental health of the patient; therefore, effective therapies are required to promote wound healing. However, traditional treatment methods have limited efficacy. Exosomes secreted by stem cells used for oral and maxillofacial wound healing have shown outstanding results. Stem cell-derived exosomes possess the regenerative and repair ability of stem cells. Moreover, they are nontumorigenic and have good biosafety. However, the application of natural stem cell exosomes is limited owing to their low yield, impurity, lack of targeting, and low drug delivery rate. Many modification methods have been developed to engineered stem cell exosomes with beneficial properties, such as modifying parent cells and directly processing stem cell exosomes. These methods include coincubation, genetic engineering, electroporation, ultrasound, and artificial synthesis of engineered stem cell exosomes. These engineered stem cell exosomes can cargo nucleic acids, proteins, and small molecules. This gives them anti-inflammatory and cell proliferation regulatory abilities and enables the targeted promotion of efficient soft tissue repair after trauma. Engineered stem cell exosomes can decrease inflammation, promote fibroblast proliferation, and angiogenesis, and decrease scar formation to promote oral and maxillofacial wound healing, including diabetic and burn wounds. Thus, engineered stem cell exosomes are an effective treatment that has the potential for oral and maxillofacial wound healing. |
| first_indexed | 2024-04-12T11:51:46Z |
| format | Article |
| id | doaj.art-a5f34f1153164b57a667321e01d33feb |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T11:51:46Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-a5f34f1153164b57a667321e01d33feb2022-12-22T03:34:09ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-10-011010.3389/fbioe.2022.10382611038261Engineered stem cell exosomes for oral and maxillofacial wound healingMing Hao0Ming Hao1MengNa Duan2Zhijing Yang3Zhijing Yang4Hengzong Zhou5Shuangji Li6Shuangji Li7Jingcheng Xiang8Jingcheng Xiang9Han Wu10Han Wu11Huimin Liu12Huimin Liu13Lu Chang14Lu Chang15Dongxu Wang16Weiwei Liu17Weiwei Liu18Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, Jilin, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, ChinaLaboratory Animal Center, College of Animal Science, Jilin University, Changchun, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, ChinaLaboratory Animal Center, College of Animal Science, Jilin University, Changchun, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, ChinaWound healing of the oral and maxillofacial area affects the quality of life and mental health of the patient; therefore, effective therapies are required to promote wound healing. However, traditional treatment methods have limited efficacy. Exosomes secreted by stem cells used for oral and maxillofacial wound healing have shown outstanding results. Stem cell-derived exosomes possess the regenerative and repair ability of stem cells. Moreover, they are nontumorigenic and have good biosafety. However, the application of natural stem cell exosomes is limited owing to their low yield, impurity, lack of targeting, and low drug delivery rate. Many modification methods have been developed to engineered stem cell exosomes with beneficial properties, such as modifying parent cells and directly processing stem cell exosomes. These methods include coincubation, genetic engineering, electroporation, ultrasound, and artificial synthesis of engineered stem cell exosomes. These engineered stem cell exosomes can cargo nucleic acids, proteins, and small molecules. This gives them anti-inflammatory and cell proliferation regulatory abilities and enables the targeted promotion of efficient soft tissue repair after trauma. Engineered stem cell exosomes can decrease inflammation, promote fibroblast proliferation, and angiogenesis, and decrease scar formation to promote oral and maxillofacial wound healing, including diabetic and burn wounds. Thus, engineered stem cell exosomes are an effective treatment that has the potential for oral and maxillofacial wound healing.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1038261/fullengineeredexosomesstem cellsoral and maxillofacial surgerywound healing |
| spellingShingle | Ming Hao Ming Hao MengNa Duan Zhijing Yang Zhijing Yang Hengzong Zhou Shuangji Li Shuangji Li Jingcheng Xiang Jingcheng Xiang Han Wu Han Wu Huimin Liu Huimin Liu Lu Chang Lu Chang Dongxu Wang Weiwei Liu Weiwei Liu Engineered stem cell exosomes for oral and maxillofacial wound healing Frontiers in Bioengineering and Biotechnology engineered exosomes stem cells oral and maxillofacial surgery wound healing |
| title | Engineered stem cell exosomes for oral and maxillofacial wound healing |
| title_full | Engineered stem cell exosomes for oral and maxillofacial wound healing |
| title_fullStr | Engineered stem cell exosomes for oral and maxillofacial wound healing |
| title_full_unstemmed | Engineered stem cell exosomes for oral and maxillofacial wound healing |
| title_short | Engineered stem cell exosomes for oral and maxillofacial wound healing |
| title_sort | engineered stem cell exosomes for oral and maxillofacial wound healing |
| topic | engineered exosomes stem cells oral and maxillofacial surgery wound healing |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1038261/full |
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