Polyphenols as Potent Epigenetics Agents for Cancer
Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11712 |
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| author | Peramaiyan Rajendran Salaheldin Abdelraouf Abdelsalam Kaviyarasi Renu Vishnupriya Veeraraghavan Rebai Ben Ammar Emad A. Ahmed |
| author_facet | Peramaiyan Rajendran Salaheldin Abdelraouf Abdelsalam Kaviyarasi Renu Vishnupriya Veeraraghavan Rebai Ben Ammar Emad A. Ahmed |
| author_sort | Peramaiyan Rajendran |
| collection | DOAJ |
| description | Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such as these ones are powerful anticancer agents and antioxidants. Gallic acid, kaempferol, curcumin, quercetin, and resveratrol, among others, have potent anti-tumor effects by helping reverse epigenetic changes associated with oncogene activation and tumor suppressor gene inactivation. The role dietary polyphenols plays in restoring epigenetic alterations in cancer cells with a particular focus on DNA methylation and histone modifications was summarized. We also discussed how these natural compounds modulate gene expression at the epigenetic level and described their molecular targets in cancer. It highlights the potential of polyphenols as an alternative therapeutic approach in cancer since they modulate epigenetic activity. |
| first_indexed | 2024-03-09T21:38:25Z |
| format | Article |
| id | doaj.art-a5f38eba1a18425cb15f7d1e56dcf814 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:38:25Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a5f38eba1a18425cb15f7d1e56dcf8142023-11-23T20:37:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123191171210.3390/ijms231911712Polyphenols as Potent Epigenetics Agents for CancerPeramaiyan Rajendran0Salaheldin Abdelraouf Abdelsalam1Kaviyarasi Renu2Vishnupriya Veeraraghavan3Rebai Ben Ammar4Emad A. Ahmed5Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaCentre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600 077, Tamil Nadu, IndiaCentre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600 077, Tamil Nadu, IndiaDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaHuman diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such as these ones are powerful anticancer agents and antioxidants. Gallic acid, kaempferol, curcumin, quercetin, and resveratrol, among others, have potent anti-tumor effects by helping reverse epigenetic changes associated with oncogene activation and tumor suppressor gene inactivation. The role dietary polyphenols plays in restoring epigenetic alterations in cancer cells with a particular focus on DNA methylation and histone modifications was summarized. We also discussed how these natural compounds modulate gene expression at the epigenetic level and described their molecular targets in cancer. It highlights the potential of polyphenols as an alternative therapeutic approach in cancer since they modulate epigenetic activity.https://www.mdpi.com/1422-0067/23/19/11712cancerpolyphenolepigenetics |
| spellingShingle | Peramaiyan Rajendran Salaheldin Abdelraouf Abdelsalam Kaviyarasi Renu Vishnupriya Veeraraghavan Rebai Ben Ammar Emad A. Ahmed Polyphenols as Potent Epigenetics Agents for Cancer International Journal of Molecular Sciences cancer polyphenol epigenetics |
| title | Polyphenols as Potent Epigenetics Agents for Cancer |
| title_full | Polyphenols as Potent Epigenetics Agents for Cancer |
| title_fullStr | Polyphenols as Potent Epigenetics Agents for Cancer |
| title_full_unstemmed | Polyphenols as Potent Epigenetics Agents for Cancer |
| title_short | Polyphenols as Potent Epigenetics Agents for Cancer |
| title_sort | polyphenols as potent epigenetics agents for cancer |
| topic | cancer polyphenol epigenetics |
| url | https://www.mdpi.com/1422-0067/23/19/11712 |
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