Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in China
Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) are widespread in China, with occurrences documented in humans, animals, and the environment. The dissemination of ESBL-producing E. coli is likely facilitated by the widespread use of antibiotics in human and animal agricultu...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Biosafety and Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590053624000028 |
| _version_ | 1827336676415897600 |
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| author | Sayyed Salman Zeeshan Umar Yonghong Xiao |
| author_facet | Sayyed Salman Zeeshan Umar Yonghong Xiao |
| author_sort | Sayyed Salman |
| collection | DOAJ |
| description | Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) are widespread in China, with occurrences documented in humans, animals, and the environment. The dissemination of ESBL-producing E. coli is likely facilitated by the widespread use of antibiotics in human and animal agriculture, the presence of antibiotic-resistant bacteria (ARBs) in animal feces, and close human-animal interactions. Plasmids, particularly those belonging to incompatibility (Inc) group, such as IncF, IncI, and IncH families, play a vital role in facilitating the horizontal gene transfer of ESBL genes across various sectors, from humans to animals and the environment. IS26 and IS1 elements also significantly influences the mobilization and evolution of antibiotic-resistance genes (ARGs), contributing to the spread of ESBL-producing E. coli. blaCTX-M−14, blaCTX-15, and blaCTX-M−55 are prevalent in ESBL-producing E. coli across the three domains and are often found in conjunction with other ARGs. Considering these challenges, it is imperative to take proactive measures to prevent the further spread of ARBs. This includes the judicious and responsible use of antibiotics and efforts to minimize contact with animal feces. Sector-specific strategies should be developed to effectively educate and engage relevant personnel in tackling this multifaceted problem. These efforts are vital to combat the dissemination of ESBL-producing E. coli and preserve public health. |
| first_indexed | 2024-03-07T18:36:25Z |
| format | Article |
| id | doaj.art-a5f3e395768149c695ed941e16666c10 |
| institution | Directory Open Access Journal |
| issn | 2590-0536 |
| language | English |
| last_indexed | 2024-03-07T18:36:25Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosafety and Health |
| spelling | doaj.art-a5f3e395768149c695ed941e16666c102024-03-02T04:54:43ZengElsevierBiosafety and Health2590-05362024-02-01614049Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in ChinaSayyed Salman0Zeeshan Umar1Yonghong Xiao2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, ChinaMarshall Laboratory of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen 510000, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China; Corresponding author: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China.Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) are widespread in China, with occurrences documented in humans, animals, and the environment. The dissemination of ESBL-producing E. coli is likely facilitated by the widespread use of antibiotics in human and animal agriculture, the presence of antibiotic-resistant bacteria (ARBs) in animal feces, and close human-animal interactions. Plasmids, particularly those belonging to incompatibility (Inc) group, such as IncF, IncI, and IncH families, play a vital role in facilitating the horizontal gene transfer of ESBL genes across various sectors, from humans to animals and the environment. IS26 and IS1 elements also significantly influences the mobilization and evolution of antibiotic-resistance genes (ARGs), contributing to the spread of ESBL-producing E. coli. blaCTX-M−14, blaCTX-15, and blaCTX-M−55 are prevalent in ESBL-producing E. coli across the three domains and are often found in conjunction with other ARGs. Considering these challenges, it is imperative to take proactive measures to prevent the further spread of ARBs. This includes the judicious and responsible use of antibiotics and efforts to minimize contact with animal feces. Sector-specific strategies should be developed to effectively educate and engage relevant personnel in tackling this multifaceted problem. These efforts are vital to combat the dissemination of ESBL-producing E. coli and preserve public health.http://www.sciencedirect.com/science/article/pii/S2590053624000028Escherichia coliExtended-spectrum β-lactamasesCTX-M |
| spellingShingle | Sayyed Salman Zeeshan Umar Yonghong Xiao Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in China Biosafety and Health Escherichia coli Extended-spectrum β-lactamases CTX-M |
| title | Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in China |
| title_full | Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in China |
| title_fullStr | Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in China |
| title_full_unstemmed | Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in China |
| title_short | Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in China |
| title_sort | current epidemiologic features and health dynamics of esbl producing escherichia coli in china |
| topic | Escherichia coli Extended-spectrum β-lactamases CTX-M |
| url | http://www.sciencedirect.com/science/article/pii/S2590053624000028 |
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