Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids
In our previous study, we have demonstrated that curcumin can efficiently kill the anaerobic bacterium <i>Propionibacterium acnes</i> by irradiation with low-dose blue light. The curcuminoids present in natural plant turmeric mainly include curcumin, demethoxycurcumin, and bisdemethoxycu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/23/9024 |
| Summary: | In our previous study, we have demonstrated that curcumin can efficiently kill the anaerobic bacterium <i>Propionibacterium acnes</i> by irradiation with low-dose blue light. The curcuminoids present in natural plant turmeric mainly include curcumin, demethoxycurcumin, and bisdemethoxycurcumin. However, only curcumin is commercially available. Eighteen different curcumin analogs, including demethoxycurcumin and bisdemethoxycurcumin, were synthesized in this study. Their antibacterial activity against Gram-positive aerobic bacteria <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i> was investigated using the photodynamic inactivation method. Among the three compounds in turmeric, curcumin activity is the weakest, and bisdemethoxycurcumin possesses the strongest activity. However, two synthetic compounds, (1<i>E</i>,6<i>E</i>)-1,7-bis(5-methylthiophen-2-yl)hepta-1,6-diene-3,5-dione and (1<i>E</i>,6<i>E</i>)-1,7-di(thiophen-2-yl)hepta-1,6-diene-3,5-dione, possess the best antibacterial activity among all compounds examined in this study. Their chemical stability is also better than that of bisdemethoxycurcumin, and thus has potential for future clinical applications. |
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| ISSN: | 1661-6596 1422-0067 |