The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia
Objective: Portulaca oleracea, commonly known as Purslane, is traditionally used as a sour, diuretic, and cooling herb with hemostatic properties. The present study evaluates the antianemic effect of methanolic and aqueous extracts of P. oleracea in a phenylhydrazine model of anemia.Materials and Me...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-01-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | https://ajp.mums.ac.ir/article_20965_0b3c89732501e457f016bf46223c35e8.pdf |
| _version_ | 1811195943574306816 |
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| author | Kobra Shirani Bamdad Riahi-Zanjani Seyed Navid Omidkhoda Samira Barangi Gholamreza Karimi |
| author_facet | Kobra Shirani Bamdad Riahi-Zanjani Seyed Navid Omidkhoda Samira Barangi Gholamreza Karimi |
| author_sort | Kobra Shirani |
| collection | DOAJ |
| description | Objective: Portulaca oleracea, commonly known as Purslane, is traditionally used as a sour, diuretic, and cooling herb with hemostatic properties. The present study evaluates the antianemic effect of methanolic and aqueous extracts of P. oleracea in a phenylhydrazine model of anemia.Materials and Methods: Phenylhydrazine (60 mg/kg/day, i.p., two consecutive days) was used to induce anemia in rats. The aqueous and methanolic extracts of P. oleracea were prepared, and three methods of treatment were defined with two doses (500 and 750 mg/kg, i.p.). The hematological parameters and blood cell morphology, total and direct bilirubin, and morphology, and pathology of bone marrow were evaluated.Results: The results showed that the methanolic extract has better effects than aqueous extract in improving phenylhydrazine-induced anemia. Our results showed that administration of 500 and 750 mg/kg of P. oleracea methanolic extracts for 4 days could protect against the development of anemia caused by phenylhydrazine.Conclusion: In summary, the methanolic extracts of P. oleracea might be effective in phenylhydrazine-induced anemia. |
| first_indexed | 2024-04-12T00:50:34Z |
| format | Article |
| id | doaj.art-a5f44733137246f3958f9312a2633abe |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-12T00:50:34Z |
| publishDate | 2023-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-a5f44733137246f3958f9312a2633abe2022-12-22T03:54:44ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492023-01-01131859610.22038/ajp.2022.2096520965The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemiaKobra Shirani0Bamdad Riahi-Zanjani1Seyed Navid Omidkhoda2Samira Barangi3Gholamreza Karimi4Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranMedical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, IranObjective: Portulaca oleracea, commonly known as Purslane, is traditionally used as a sour, diuretic, and cooling herb with hemostatic properties. The present study evaluates the antianemic effect of methanolic and aqueous extracts of P. oleracea in a phenylhydrazine model of anemia.Materials and Methods: Phenylhydrazine (60 mg/kg/day, i.p., two consecutive days) was used to induce anemia in rats. The aqueous and methanolic extracts of P. oleracea were prepared, and three methods of treatment were defined with two doses (500 and 750 mg/kg, i.p.). The hematological parameters and blood cell morphology, total and direct bilirubin, and morphology, and pathology of bone marrow were evaluated.Results: The results showed that the methanolic extract has better effects than aqueous extract in improving phenylhydrazine-induced anemia. Our results showed that administration of 500 and 750 mg/kg of P. oleracea methanolic extracts for 4 days could protect against the development of anemia caused by phenylhydrazine.Conclusion: In summary, the methanolic extracts of P. oleracea might be effective in phenylhydrazine-induced anemia.https://ajp.mums.ac.ir/article_20965_0b3c89732501e457f016bf46223c35e8.pdfpurslanephenylhydrazineanemiamethanolic extractaqueous extract |
| spellingShingle | Kobra Shirani Bamdad Riahi-Zanjani Seyed Navid Omidkhoda Samira Barangi Gholamreza Karimi The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia Avicenna Journal of Phytomedicine purslane phenylhydrazine anemia methanolic extract aqueous extract |
| title | The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia |
| title_full | The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia |
| title_fullStr | The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia |
| title_full_unstemmed | The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia |
| title_short | The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia |
| title_sort | hematopoietic potential of methanolic and aqueous extracts of portulaca oleracea in a phenylhydrazine model of anemia |
| topic | purslane phenylhydrazine anemia methanolic extract aqueous extract |
| url | https://ajp.mums.ac.ir/article_20965_0b3c89732501e457f016bf46223c35e8.pdf |
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