Association Between Helicobacter pylori Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, Uganda
Daisy Asiimwe,1 Isaac Bangi,1 Jospeh Esanyu,1 Daniel Ojok,1 Benedict Okot,1 Clinton Olong,1 Robert Wagubi,1 Godfrey Kisembo,2 Fred Sempijja,3 Enoch Muwanguzi,1 Benson Okongo1 1Department of Medical Laboratory Science, Mbarara University of Science and Technology, Mbarara City, Uganda; 2Department of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-01-01
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| Series: | Journal of Blood Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-between-helicobacter-pylori-infection-and-anemia-among-adu-peer-reviewed-fulltext-article-JBM |
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| author | Asiimwe D Bangi I Esanyu J Ojok D Okot B Olong C Wagubi R Kisembo G Sempijja F Muwanguzi E Okongo B |
| author_facet | Asiimwe D Bangi I Esanyu J Ojok D Okot B Olong C Wagubi R Kisembo G Sempijja F Muwanguzi E Okongo B |
| author_sort | Asiimwe D |
| collection | DOAJ |
| description | Daisy Asiimwe,1 Isaac Bangi,1 Jospeh Esanyu,1 Daniel Ojok,1 Benedict Okot,1 Clinton Olong,1 Robert Wagubi,1 Godfrey Kisembo,2 Fred Sempijja,3 Enoch Muwanguzi,1 Benson Okongo1 1Department of Medical Laboratory Science, Mbarara University of Science and Technology, Mbarara City, Uganda; 2Department of Hospital Administration, Kiryandongo General Hospital, Kiryandongo, Uganda; 3Department of Medical Laboratory Technology, Uganda Institute of Allied Health and Management Sciences - Mulago, Kampala City, UgandaCorrespondence: Benson Okongo, Department of Medical Laboratory Science, Mbarara University of Science and Technology, P.O. BOX 1410, Mbarara City, Uganda, Tel +256 778 557 867, Fax +256-485-20782, Email bokongo@must.ac.ugPurpose: To determine the prevalence of anemia and its association with Helicobacter pylori infection among adult dyspeptic patients.Patients and Methods: A cross-sectional study was conducted among 283 dyspeptic patients at Kiryandongo General Hospital, in Uganda. A structured questionnaire was administered to capture demographic and clinical characteristics of study participants. Four milliliters of blood were then collected into an EDTA vacutainer for Complete Blood Count (CBC) and analyzed using HUMA COUNT 30TS, and peripheral blood smears were made and stained using Giemsa stain. Anemia was defined as hemoglobin levels < 12g/dl in females and < 13g/dl in men according to the World Health Organization (WHO). Helicobacter pylori (H. pylori) stool antigen test was performed using Whole power H. pylori Ag rapid test device, and saline stool preparation was examined for intestinal parasites. Chi-squared test and Logistic regression were performed to determine association, and a p-value of ≤ 0.05 was considered statistically significant.Results: The overall prevalence of Helicobacter pylori infection was 42.4% (120/283). The prevalence of anemia among H. pylori-infected patients was 25.8% (31/120) and 15.3% (25/163) among H. pylori-negative counterparts. H. pylori infection was significantly associated with anemia (p-value 0.042), age (p-value 0.02, 0.009), water sources (p-value 0.0049,) and intestinal parasitic infestation (p-value 0.02), respectively.Conclusion: This study has shown that the prevalence of H. pylori infection and anemia is high among dyspeptic patients at Kiryandongo General Hospital. H. pylori infection was found associated with anemia, age, water sources, and intestinal parasitic infestation. Routine screening of anemia in H. pylori-infected individuals and further studies to explore the relationship between anemia and H. pylori disease is highly recommended.Keywords: anemia, prevalence, Helicobacter pylori infection |
| first_indexed | 2024-04-10T20:42:56Z |
| format | Article |
| id | doaj.art-a5f57c4c88384a6da521a7f28034825e |
| institution | Directory Open Access Journal |
| issn | 1179-2736 |
| language | English |
| last_indexed | 2024-04-10T20:42:56Z |
| publishDate | 2023-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj.art-a5f57c4c88384a6da521a7f28034825e2023-01-24T18:10:57ZengDove Medical PressJournal of Blood Medicine1179-27362023-01-01Volume 14576681191Association Between Helicobacter pylori Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, UgandaAsiimwe DBangi IEsanyu JOjok DOkot BOlong CWagubi RKisembo GSempijja FMuwanguzi EOkongo BDaisy Asiimwe,1 Isaac Bangi,1 Jospeh Esanyu,1 Daniel Ojok,1 Benedict Okot,1 Clinton Olong,1 Robert Wagubi,1 Godfrey Kisembo,2 Fred Sempijja,3 Enoch Muwanguzi,1 Benson Okongo1 1Department of Medical Laboratory Science, Mbarara University of Science and Technology, Mbarara City, Uganda; 2Department of Hospital Administration, Kiryandongo General Hospital, Kiryandongo, Uganda; 3Department of Medical Laboratory Technology, Uganda Institute of Allied Health and Management Sciences - Mulago, Kampala City, UgandaCorrespondence: Benson Okongo, Department of Medical Laboratory Science, Mbarara University of Science and Technology, P.O. BOX 1410, Mbarara City, Uganda, Tel +256 778 557 867, Fax +256-485-20782, Email bokongo@must.ac.ugPurpose: To determine the prevalence of anemia and its association with Helicobacter pylori infection among adult dyspeptic patients.Patients and Methods: A cross-sectional study was conducted among 283 dyspeptic patients at Kiryandongo General Hospital, in Uganda. A structured questionnaire was administered to capture demographic and clinical characteristics of study participants. Four milliliters of blood were then collected into an EDTA vacutainer for Complete Blood Count (CBC) and analyzed using HUMA COUNT 30TS, and peripheral blood smears were made and stained using Giemsa stain. Anemia was defined as hemoglobin levels < 12g/dl in females and < 13g/dl in men according to the World Health Organization (WHO). Helicobacter pylori (H. pylori) stool antigen test was performed using Whole power H. pylori Ag rapid test device, and saline stool preparation was examined for intestinal parasites. Chi-squared test and Logistic regression were performed to determine association, and a p-value of ≤ 0.05 was considered statistically significant.Results: The overall prevalence of Helicobacter pylori infection was 42.4% (120/283). The prevalence of anemia among H. pylori-infected patients was 25.8% (31/120) and 15.3% (25/163) among H. pylori-negative counterparts. H. pylori infection was significantly associated with anemia (p-value 0.042), age (p-value 0.02, 0.009), water sources (p-value 0.0049,) and intestinal parasitic infestation (p-value 0.02), respectively.Conclusion: This study has shown that the prevalence of H. pylori infection and anemia is high among dyspeptic patients at Kiryandongo General Hospital. H. pylori infection was found associated with anemia, age, water sources, and intestinal parasitic infestation. Routine screening of anemia in H. pylori-infected individuals and further studies to explore the relationship between anemia and H. pylori disease is highly recommended.Keywords: anemia, prevalence, Helicobacter pylori infectionhttps://www.dovepress.com/association-between-helicobacter-pylori-infection-and-anemia-among-adu-peer-reviewed-fulltext-article-JBManemiaprevalencehelicobacter pylori infection |
| spellingShingle | Asiimwe D Bangi I Esanyu J Ojok D Okot B Olong C Wagubi R Kisembo G Sempijja F Muwanguzi E Okongo B Association Between Helicobacter pylori Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, Uganda Journal of Blood Medicine anemia prevalence helicobacter pylori infection |
| title | Association Between Helicobacter pylori Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, Uganda |
| title_full | Association Between Helicobacter pylori Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, Uganda |
| title_fullStr | Association Between Helicobacter pylori Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, Uganda |
| title_full_unstemmed | Association Between Helicobacter pylori Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, Uganda |
| title_short | Association Between Helicobacter pylori Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, Uganda |
| title_sort | association between helicobacter pylori infection and anemia among adult dyspeptic patients attending kiryandongo general hospital uganda |
| topic | anemia prevalence helicobacter pylori infection |
| url | https://www.dovepress.com/association-between-helicobacter-pylori-infection-and-anemia-among-adu-peer-reviewed-fulltext-article-JBM |
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