Targeting Drug Chemo-Resistance in Cancer Using Natural Products
Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are ac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/10/1353 |
| _version_ | 1797515236070129664 |
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| author | Wamidh H. Talib Ahmad Riyad Alsayed Muna Barakat May Ibrahim Abu-Taha Asma Ismail Mahmod |
| author_facet | Wamidh H. Talib Ahmad Riyad Alsayed Muna Barakat May Ibrahim Abu-Taha Asma Ismail Mahmod |
| author_sort | Wamidh H. Talib |
| collection | DOAJ |
| description | Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources of chemotherapeutic agents. Additionally, they have multiple mechanisms of action to inhibit various targets involved in the development of drug resistance. In this review, we have summarized the basic research and clinical applications of natural products as possible inhibitors for drug resistance in cancer. The molecular targets and the mechanisms of action of each natural product are also explained. Diverse drug resistance biomarkers were sensitive to natural products. P-glycoprotein and breast cancer resistance protein can be targeted by a large number of natural products. On the other hand, protein kinase C and topoisomerases were less sensitive to most of the studied natural products. The studies discussed in this review will provide a solid ground for scientists to explore the possible use of natural products in combination anticancer therapies to overcome drug resistance by targeting multiple drug resistance mechanisms. |
| first_indexed | 2024-03-10T06:42:39Z |
| format | Article |
| id | doaj.art-a5f7a46da9ec4b58be505c62193099fb |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:42:39Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a5f7a46da9ec4b58be505c62193099fb2023-11-22T17:30:34ZengMDPI AGBiomedicines2227-90592021-09-01910135310.3390/biomedicines9101353Targeting Drug Chemo-Resistance in Cancer Using Natural ProductsWamidh H. Talib0Ahmad Riyad Alsayed1Muna Barakat2May Ibrahim Abu-Taha3Asma Ismail Mahmod4Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931-166, JordanDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931-166, JordanDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931-166, JordanDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931-166, JordanDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931-166, JordanCancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources of chemotherapeutic agents. Additionally, they have multiple mechanisms of action to inhibit various targets involved in the development of drug resistance. In this review, we have summarized the basic research and clinical applications of natural products as possible inhibitors for drug resistance in cancer. The molecular targets and the mechanisms of action of each natural product are also explained. Diverse drug resistance biomarkers were sensitive to natural products. P-glycoprotein and breast cancer resistance protein can be targeted by a large number of natural products. On the other hand, protein kinase C and topoisomerases were less sensitive to most of the studied natural products. The studies discussed in this review will provide a solid ground for scientists to explore the possible use of natural products in combination anticancer therapies to overcome drug resistance by targeting multiple drug resistance mechanisms.https://www.mdpi.com/2227-9059/9/10/1353anticancer natural productsdrug effluxdrug detoxificationplants derived natural products |
| spellingShingle | Wamidh H. Talib Ahmad Riyad Alsayed Muna Barakat May Ibrahim Abu-Taha Asma Ismail Mahmod Targeting Drug Chemo-Resistance in Cancer Using Natural Products Biomedicines anticancer natural products drug efflux drug detoxification plants derived natural products |
| title | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
| title_full | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
| title_fullStr | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
| title_full_unstemmed | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
| title_short | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
| title_sort | targeting drug chemo resistance in cancer using natural products |
| topic | anticancer natural products drug efflux drug detoxification plants derived natural products |
| url | https://www.mdpi.com/2227-9059/9/10/1353 |
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