Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination
The new coronavirus (COVID-19) pandemic has resulted in the unprecedented production of vaccines. In this context, the possible adverse effects remain to be identified and reported. In this article, we report the case of a young female patient who developed anti-3-hydroxy-3-methylglutaryl-coenzyme A...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2023/7061783 |
| _version_ | 1797812117721579520 |
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| author | Marta Rodrigues de Carvalho Myrian Mathildes Sá de Deus Rocha Vinícius Alves Bezerra Maciel Eduardo de Pontes Maria Cristina del Negro Julio Salgado Antunes Vinícius Viana Abreu Montanaro Rubens Nelson Morato Fernandez |
| author_facet | Marta Rodrigues de Carvalho Myrian Mathildes Sá de Deus Rocha Vinícius Alves Bezerra Maciel Eduardo de Pontes Maria Cristina del Negro Julio Salgado Antunes Vinícius Viana Abreu Montanaro Rubens Nelson Morato Fernandez |
| author_sort | Marta Rodrigues de Carvalho |
| collection | DOAJ |
| description | The new coronavirus (COVID-19) pandemic has resulted in the unprecedented production of vaccines. In this context, the possible adverse effects remain to be identified and reported. In this article, we report the case of a young female patient who developed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMG-CoA) immune-mediated necrotizing myositis (IMNM) after receiving the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine. The diagnosis of probable post-vaccination IMNM was made due to the absence of other factors that may have led to the development of autoantibodies (medicines; e.g., statins, drugs) and the temporal relationship between exposure and event. This case report is the first to suggest that a COVID-19 vaccine may trigger anti-HMG-CoA reductase necrotizing myopathy. |
| first_indexed | 2024-03-13T07:33:32Z |
| format | Article |
| id | doaj.art-a5f844a97e7a4e0cb2e324d156623d92 |
| institution | Directory Open Access Journal |
| issn | 2090-6676 |
| language | English |
| last_indexed | 2024-03-13T07:33:32Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj.art-a5f844a97e7a4e0cb2e324d156623d922023-06-04T00:00:01ZengHindawi LimitedCase Reports in Neurological Medicine2090-66762023-01-01202310.1155/2023/7061783Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 VaccinationMarta Rodrigues de Carvalho0Myrian Mathildes Sá de Deus Rocha1Vinícius Alves Bezerra2Maciel Eduardo de Pontes3Maria Cristina del Negro4Julio Salgado Antunes5Vinícius Viana Abreu Montanaro6Rubens Nelson Morato Fernandez7Department of Neurology and Clinical NeurophysiologyDepartment of Neurology and Clinical NeurophysiologyDepartment of RadiologyDepartment of Neurology and Clinical NeurophysiologyDepartment of NeurologyDepartment of PathologyDepartment of NeurologyDepartment of Neurology and Clinical NeurophysiologyThe new coronavirus (COVID-19) pandemic has resulted in the unprecedented production of vaccines. In this context, the possible adverse effects remain to be identified and reported. In this article, we report the case of a young female patient who developed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMG-CoA) immune-mediated necrotizing myositis (IMNM) after receiving the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine. The diagnosis of probable post-vaccination IMNM was made due to the absence of other factors that may have led to the development of autoantibodies (medicines; e.g., statins, drugs) and the temporal relationship between exposure and event. This case report is the first to suggest that a COVID-19 vaccine may trigger anti-HMG-CoA reductase necrotizing myopathy.http://dx.doi.org/10.1155/2023/7061783 |
| spellingShingle | Marta Rodrigues de Carvalho Myrian Mathildes Sá de Deus Rocha Vinícius Alves Bezerra Maciel Eduardo de Pontes Maria Cristina del Negro Julio Salgado Antunes Vinícius Viana Abreu Montanaro Rubens Nelson Morato Fernandez Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination Case Reports in Neurological Medicine |
| title | Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination |
| title_full | Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination |
| title_fullStr | Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination |
| title_full_unstemmed | Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination |
| title_short | Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination |
| title_sort | anti 3 hydroxy 3 methylglutaryl coenzyme a reductase immune mediated necrotizing myopathy following mrna sars cov 2 vaccination |
| url | http://dx.doi.org/10.1155/2023/7061783 |
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