Allium fistulosum (Welsh onion) and Portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting TGF-β and IGF-1 signaling
Longitudinal bone growth mainly occurs during adolescence and can be enhanced by growth hormones. We hypothesized that water extracts from roots of Allium fistulosum L. (Welsh onion, WO; 15 or 45 mg/kg bw/day) and Portulaca oleracea L. (PO; 15 or 45 mg/kg bw/day) can stimulate longitudinal bone grow...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619302440 |
| _version_ | 1818667058131369984 |
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| author | Byoung-Seob Ko Jin Ah Ryuk Joo Tae Hwang Ting Zhang Xuangao Wu Hye Jin Kim Qiu Jing Yi Sunmin Park |
| author_facet | Byoung-Seob Ko Jin Ah Ryuk Joo Tae Hwang Ting Zhang Xuangao Wu Hye Jin Kim Qiu Jing Yi Sunmin Park |
| author_sort | Byoung-Seob Ko |
| collection | DOAJ |
| description | Longitudinal bone growth mainly occurs during adolescence and can be enhanced by growth hormones. We hypothesized that water extracts from roots of Allium fistulosum L. (Welsh onion, WO; 15 or 45 mg/kg bw/day) and Portulaca oleracea L. (PO; 15 or 45 mg/kg bw/day) can stimulate longitudinal bone growth in weanling male rats for 4 weeks. Femur and tibia lengths were higher in the WO-H and PO-H groups than in the control. The proliferative and hypertrophic zones of the growth plate were greater in the legs of WO-H and PO-H rats than in the control; a similar increase was observed in the positive-control (growth hormone, 20 μg/kg bw/day). WO-H and PO-H treatments were found to potentiate insulin-like growth factor-1 (IGF-1) signaling (pIRS-2 → pAkt) in MG-63 osteoblasts compared to control. WO-H and PO increased cell proliferation possibly by activating transforming growth factor (TGF)-β signaling via elevated BMP-2 and Smad4 expression in MG-63 cells. In conclusion, WO and PO are potential to promote the proliferation of the leg growth plate similar to growth hormone. |
| first_indexed | 2024-12-17T06:14:23Z |
| format | Article |
| id | doaj.art-a5fa382bfe6547f7adefecbd47f3e452 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T06:14:23Z |
| publishDate | 2019-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-a5fa382bfe6547f7adefecbd47f3e4522022-12-21T22:00:33ZengElsevierJournal of Functional Foods1756-46462019-07-0158151160Allium fistulosum (Welsh onion) and Portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting TGF-β and IGF-1 signalingByoung-Seob Ko0Jin Ah Ryuk1Joo Tae Hwang2Ting Zhang3Xuangao Wu4Hye Jin Kim5Qiu Jing Yi6Sunmin Park7Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, South KoreaKorean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, South KoreaKorean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, South KoreaFood & Nutrition, Obesity/Diabetes Center, Hoseo University, 336-795 Asan, South KoreaFood & Nutrition, Obesity/Diabetes Center, Hoseo University, 336-795 Asan, South KoreaKorean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, South KoreaFood & Nutrition, Obesity/Diabetes Center, Hoseo University, 336-795 Asan, South KoreaFood & Nutrition, Obesity/Diabetes Center, Hoseo University, 336-795 Asan, South Korea; Corresponding author at: Food and Nutrition, Hoseo University, 165 Sechul-Ri, BaeBang-Yup, Asan-Si, ChungNam-Do 336-795, South Korea.Longitudinal bone growth mainly occurs during adolescence and can be enhanced by growth hormones. We hypothesized that water extracts from roots of Allium fistulosum L. (Welsh onion, WO; 15 or 45 mg/kg bw/day) and Portulaca oleracea L. (PO; 15 or 45 mg/kg bw/day) can stimulate longitudinal bone growth in weanling male rats for 4 weeks. Femur and tibia lengths were higher in the WO-H and PO-H groups than in the control. The proliferative and hypertrophic zones of the growth plate were greater in the legs of WO-H and PO-H rats than in the control; a similar increase was observed in the positive-control (growth hormone, 20 μg/kg bw/day). WO-H and PO-H treatments were found to potentiate insulin-like growth factor-1 (IGF-1) signaling (pIRS-2 → pAkt) in MG-63 osteoblasts compared to control. WO-H and PO increased cell proliferation possibly by activating transforming growth factor (TGF)-β signaling via elevated BMP-2 and Smad4 expression in MG-63 cells. In conclusion, WO and PO are potential to promote the proliferation of the leg growth plate similar to growth hormone.http://www.sciencedirect.com/science/article/pii/S1756464619302440Welsh onionPortulaca oleraceaLongitudinal bone growthTGF-βIGF-1 |
| spellingShingle | Byoung-Seob Ko Jin Ah Ryuk Joo Tae Hwang Ting Zhang Xuangao Wu Hye Jin Kim Qiu Jing Yi Sunmin Park Allium fistulosum (Welsh onion) and Portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting TGF-β and IGF-1 signaling Journal of Functional Foods Welsh onion Portulaca oleracea Longitudinal bone growth TGF-β IGF-1 |
| title | Allium fistulosum (Welsh onion) and Portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting TGF-β and IGF-1 signaling |
| title_full | Allium fistulosum (Welsh onion) and Portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting TGF-β and IGF-1 signaling |
| title_fullStr | Allium fistulosum (Welsh onion) and Portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting TGF-β and IGF-1 signaling |
| title_full_unstemmed | Allium fistulosum (Welsh onion) and Portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting TGF-β and IGF-1 signaling |
| title_short | Allium fistulosum (Welsh onion) and Portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting TGF-β and IGF-1 signaling |
| title_sort | allium fistulosum welsh onion and portulaca oleracea increase longitudinal bone growth in weanling rats possibly by promoting tgf β and igf 1 signaling |
| topic | Welsh onion Portulaca oleracea Longitudinal bone growth TGF-β IGF-1 |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619302440 |
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