Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw
Despite medication-related osteonecrosis of the jaw (MRONJ) being first reported in 2003, the optimal treatment and prevention modalities for MRONJ are not clear. As a result, dentistry, oral surgery, and departments involved in the treatment of cancer and bone diseases are struggling with the manag...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.902349/full |
| _version_ | 1811305782065496064 |
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| author | Nobuyuki Kaibuchi Nobuyuki Kaibuchi Takanori Iwata Takanori Iwata Yoko Kawase Koga Toshihiro Okamoto |
| author_facet | Nobuyuki Kaibuchi Nobuyuki Kaibuchi Takanori Iwata Takanori Iwata Yoko Kawase Koga Toshihiro Okamoto |
| author_sort | Nobuyuki Kaibuchi |
| collection | DOAJ |
| description | Despite medication-related osteonecrosis of the jaw (MRONJ) being first reported in 2003, the optimal treatment and prevention modalities for MRONJ are not clear. As a result, dentistry, oral surgery, and departments involved in the treatment of cancer and bone diseases are struggling with the management of MRONJ. Several cases of MRONJ cannot be managed by conventional treatment strategies recommended in various position papers. Therefore, studies have been conducted to investigate the efficacy of novel therapies for MRONJ. However, the optimal treatment is unknown. Several cell therapies including autologous cell transplantation have been reported for MRONJ. Although the efficacy of cell therapy for MRONJ has been demonstrated, large, statistically accurate clinical trials are lacking. We have been investigating the efficacy of MRONJ treatment using mesenchymal stromal cell (MSC) sheets since 2013 and confirmed its efficacy through various experiments, wherein MSC sheets were transplanted in model rats and beagle dogs with MRONJ-like lesions. Based on these results, we are planning to conduct a clinical trial of MRONJ therapy using periodontal ligament-derived MSC sheets. |
| first_indexed | 2024-04-13T08:32:33Z |
| format | Article |
| id | doaj.art-a5fabde298ab458ab9f33a424f3bcab3 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T08:32:33Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-a5fabde298ab458ab9f33a424f3bcab32022-12-22T02:54:12ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-05-011010.3389/fbioe.2022.902349902349Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the JawNobuyuki Kaibuchi0Nobuyuki Kaibuchi1Takanori Iwata2Takanori Iwata3Yoko Kawase Koga4Toshihiro Okamoto5Department of Oral and Maxillofacial Surgery, Tokyo Women’s Medical University School of Medicine, Shinjuku, JapanInstitute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University (TWIns), Tokyo, JapanDepartment of Oral and Maxillofacial Surgery, Tokyo Women’s Medical University School of Medicine, Shinjuku, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Oral and Maxillofacial Surgery, Tokyo Women’s Medical University School of Medicine, Shinjuku, JapanDepartment of Oral and Maxillofacial Surgery, Tokyo Women’s Medical University School of Medicine, Shinjuku, JapanDespite medication-related osteonecrosis of the jaw (MRONJ) being first reported in 2003, the optimal treatment and prevention modalities for MRONJ are not clear. As a result, dentistry, oral surgery, and departments involved in the treatment of cancer and bone diseases are struggling with the management of MRONJ. Several cases of MRONJ cannot be managed by conventional treatment strategies recommended in various position papers. Therefore, studies have been conducted to investigate the efficacy of novel therapies for MRONJ. However, the optimal treatment is unknown. Several cell therapies including autologous cell transplantation have been reported for MRONJ. Although the efficacy of cell therapy for MRONJ has been demonstrated, large, statistically accurate clinical trials are lacking. We have been investigating the efficacy of MRONJ treatment using mesenchymal stromal cell (MSC) sheets since 2013 and confirmed its efficacy through various experiments, wherein MSC sheets were transplanted in model rats and beagle dogs with MRONJ-like lesions. Based on these results, we are planning to conduct a clinical trial of MRONJ therapy using periodontal ligament-derived MSC sheets.https://www.frontiersin.org/articles/10.3389/fbioe.2022.902349/fullmultipotent stromal cellscell sheetmedication related osteonecrosis of the jawantiresorptive agent-related osteonecrosis of the jawperiodontal ligamentcell therapy |
| spellingShingle | Nobuyuki Kaibuchi Nobuyuki Kaibuchi Takanori Iwata Takanori Iwata Yoko Kawase Koga Toshihiro Okamoto Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw Frontiers in Bioengineering and Biotechnology multipotent stromal cells cell sheet medication related osteonecrosis of the jaw antiresorptive agent-related osteonecrosis of the jaw periodontal ligament cell therapy |
| title | Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw |
| title_full | Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw |
| title_fullStr | Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw |
| title_full_unstemmed | Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw |
| title_short | Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw |
| title_sort | novel cell therapy using mesenchymal stromal cell sheets for medication related osteonecrosis of the jaw |
| topic | multipotent stromal cells cell sheet medication related osteonecrosis of the jaw antiresorptive agent-related osteonecrosis of the jaw periodontal ligament cell therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.902349/full |
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